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Immunity (Cambridge, Mass.), ISSN 1074-7613, 11/2018, Volume 49, Issue 5, pp. 873 - 885.e7
Receptor interacting protein 2 (RIP2) plays a role in sensing intracellular pathogens, but its function in T cells is unclear... 
atherosclerosis | Chlamydia pneumoniae | IL-17 | RORα | Th17 | chronic inflammation | RIP2 | T(H)17 CELLS | TGF-BETA | INNATE IMMUNE-RESPONSES | INFLAMMATION | HOST-DEFENSE | ATHEROSCLEROSIS | INFECTION | NOD2 | IMMUNOLOGY | NF-KAPPA-B | T-Lymphocyte Subsets - immunology | Encephalomyelitis, Autoimmune, Experimental - metabolism | T-Lymphocyte Subsets - cytology | Encephalomyelitis, Autoimmune, Experimental - etiology | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism | Cell Differentiation - genetics | Inflammation - metabolism | Th17 Cells - metabolism | Atherosclerosis | Th17 Cells - cytology | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - mortality | Immunophenotyping | Interleukin-1beta | Interleukin-17 - biosynthesis | Mice, Knockout | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | T-Lymphocyte Subsets - metabolism | Biomarkers | Inflammation - genetics | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Caspase Activation and Recruitment Domain | Oligomers | Medical research | Pneumonia | Interleukins | Bacterial pneumonia | Communicable diseases | Medicine, Experimental | Inflammation | Research institutes | T cells | Cell differentiation | Sexually transmitted diseases--STD | Disease | Interleukin | Helper cells | Differentiation (biology) | Chronic infection | Infections | Lymphocytes T | Kinases | Proteins | Lymphocytes | Interleukin 1 | Chronic illnesses | Antigens | Oligomerization | Cytokines | Mortality | Gene expression | Experimental allergic encephalomyelitis | CD4 antigen | Lungs | Arteriosclerosis | RIP2, IL-17
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 30, pp. 25565 - 25576
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 05/2014, Volume 16, Issue 2, pp. R28 - R28
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2016, Volume 6, p. 650
Upon infection with intracellular bacteria, nucleotide oligomerization domain protein 2 recognizes bacterial muramyl dipeptide and binds, subsequently, to receptor-interacting serine/threonine kinase 2 (RIPK2... 
Listeria monocytogenes | CYLD | Receptor-interacting protein kinase-2 | Macrophages | Antibacterial immune responses | LISTERIA-MONOCYTOGENES | INNATE | IMMUNOLOGY | TUMOR-SUPPRESSOR CYLD | receptor-interacting protein kinase-2 | NEGATIVE REGULATOR | macrophages | INTERFERON-GAMMA | NITRIC-OXIDE | INFECTION | MICE | antibacterial immune responses | NF-KAPPA-B | RIP2 | Immune response | Observations | Health aspects | Protein kinases
Journal Article
Allergy, asthma & immunology research, ISSN 2092-7355, 03/2014, Volume 6, Issue 2, pp. 163 - 168
.... Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with-the severity of allergic asthma in children... 
airway inflammation | IgE | ovalbumin | RIP2 | Th2 | IMMUNE-RESPONSE | RECOGNITION | INNATE | NOD1 | IMMUNOLOGY | PATHOGENESIS | ALLERGY | TOLL-LIKE RECEPTORS | ASTHMA | INFECTION | ASSOCIATION | IMMUNOGLOBULIN-E | Original | 내과학
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2007, Volume 178, Issue 4, pp. 2380 - 2386
Journal Article
Protein & cell, ISSN 1674-800X, 2017, Volume 8, Issue 1, pp. 55 - 66
... Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2 University of Chinese Academy of Sciences... 
细菌感染 | 炎性细胞因子 | 胞壁酰二肽 | 内质网应激 | 磷酸化 | Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | LRRK2 | NF-κB activation | Nod2 | Inflammation | Developmental Biology | Cell Biology | Rip2 | INNATE | CELL BIOLOGY | REGULATOR | NF-kappa B activation | REPEAT KINASE 2 | DISEASE | PARKINSONS | MUTATIONS | STRESS | ASSOCIATION | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - immunology | Humans | Immunity, Innate - genetics | Nod2 Signaling Adaptor Protein - immunology | Nod2 Signaling Adaptor Protein - genetics | Inflammation - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - immunology | Signal Transduction - genetics | Nod1 Signaling Adaptor Protein - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Mice, Knockout | Signal Transduction - immunology | Phosphorylation - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | HEK293 Cells | Inflammation - genetics | Mice | Phosphorylation - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics | Cytokines - immunology | Nod1 Signaling Adaptor Protein - genetics | Cytokines | Leprosy | Bacterial infections
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2005, Volume 25, Issue 50, pp. 11645 - 11654
.... Receptor interacting protein-2 (Rip2) and caspase recruitment domain (CARD) only protein (Cop) are two CARD proteins with significant homology to the caspase-1 CARD and modulate caspase-1 activation in inflammation... 
RNA interference | Huntington's disease | Cell death | Cop | Caspase-1 | Rip2 | PATHWAYS | APOPTOSIS | cell death | FUNCTIONAL-ROLE | DOMINANT-NEGATIVE MUTANT | NEUROSCIENCES | INTERLEUKIN-1-BETA CONVERTING-ENZYME | INHIBITION | ISCHEMIC BRAIN-INJURY | MICE | TRANSGENIC MOUSE MODEL | caspase-1 | EXPRESSION | Neurons - pathology | Receptor-Interacting Protein Serine-Threonine Kinases | Humans | Huntington Disease - pathology | Caspase 1 - metabolism | Stem Cells - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Neurons - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Huntington Disease - enzymology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Caspase Inhibitors | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - antagonists & inhibitors | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Death - physiology | Caspase 1 - genetics | Huntington Disease - genetics | Stem Cells - pathology | Mice | HeLa Cells | Enzyme Activation - physiology | Neurobiology of Disease
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 179 - 190
...) stimulating the NOD2-RIP2 (receptor-interacting protein 2) complex to activate signalling pathways important for antibacterial defence... 
Pro-inflammatory cytokines | Nucleotide-binding oligomerization domain 2 (NOD2) | Muramyl dipeptide (MDP) | Receptor-interacting protein 2 (RIP2) | Transforming-growth-factor-β-activated kinase-1 (TAK1) | ACTIVATION | CROHNS-DISEASE | muramyl dipeptide (MDP) | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOD2 | P38 MAP KINASE | nucleotide-binding oligomerization domain 2 (NOD2) | TAK1 | pro-inflammatory cytokines | transforming-growth-factor-beta-activated kinase-1 (TAK1) | IN-VIVO | receptor-interacting protein 2 (RIP2) | FRAMESHIFT MUTATION | NF-KAPPA-B | ADAPTIVE IMMUNE-RESPONSES | PROTEIN-KINASE INHIBITORS | Cell Line | Signal Transduction | Humans | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | DNA Primers | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Nod2 Signaling Adaptor Protein - metabolism | Base Sequence | Interleukin-1beta - biosynthesis | Pyridines - pharmacology | Catalysis | Enzyme Activation | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Interleukin-1beta - antagonists & inhibitors | KI, kinase inactive | CK1, ‘casein kinase 1’ | TLR, Toll-like receptor | WT, wild-type | TNF, tumour necrosis factor | HEK-293, human embryonic kidney 293 cells | JNK, c-Jun N-terminal kinase | MDP, muramyl dipeptide | TAK1, transforming-growth-factor-β-activated kinase-1 | transforming-growth-factor-β-activated kinase-1 (TAK1) | ERK, extracellular-signal-regulated kinase | K63-pUb, Lys63-linked polyubiquitin | RIP2, receptor-interacting protein 2 | MKK1, MAPK kinase-1 | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | GAK, cyclin G-associated kinase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | IKKβ, inhibitor of nuclear factor κB kinase β | GST, glutathione S-transferase | NF-κB, nuclear factor κB | NEMO, nuclear factor κB essential modifier | HA, haemagglutinin | NOD, nucleotide-binding oligomerization domain | TRAF6, TNF-receptor-associated factor 6 | M-TriDAP, muramyl-N-acetyl-L-Ala-D-Glu-m-diaminopimelic acid | IL, interleukin | LPS, lipopolysaccharide | shRNA, short hairpin RNA | VSV-G, vesicular-stomatitis-virus envelope glycoprotein | PBMCs, peripheral-blood mononuclear cells | Tpl2, tumour progression locus 2 | FCS, foetal-calf serum | MAPK, mitogen-activated protein kinase
Journal Article
Molecular cell, ISSN 1097-2765, 2018, Volume 69, Issue 4, pp. 551 - 565.e7
Journal Article