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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 6, pp. 1632 - 1642
Background Eosinophils are a subset of granulocytes that can be involved in the pathogenesis of different diseases, including allergy. Their effector functions... 
Allergy and Immunology | necrosis | eosinophilic disease | reactive oxygen species | non-apoptotic cell death | RIP kinase | Autophagy | mixed lineage kinase-like | eosinophil cytolysis | necroptosis | ACTIVATION | PROGRAMMED NECROSIS | DOMAIN-LIKE | NECROTIC DEATH | EXTRACELLULAR DNA TRAPS | RELEASE | IMMUNOLOGY | CELL-DEATH | ALLERGY | IN-VIVO | PIECEMEAL DEGRANULATION | RIP3 | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Signal Transduction | Humans | Cells, Cultured | Hypersensitivity - immunology | Molecular Targeted Therapy | Cell Adhesion | Eosinophils - immunology | Immunoglobulins, Intravenous - metabolism | Complement C3b - metabolism | Eosinophilic Esophagitis - immunology | Cytotoxicity, Immunologic | Skin - immunology | Skin diseases | Cell death | Mitogens | Protein kinases | Fluorescence microscopy | TOR protein | Immunohistochemistry | Cytolysis | Cell culture | Reactive oxygen species | Phosphorylation | Intravenous administration | Pathogenesis | Fluorescence | Cytotoxicity | Activation | Kinases | Experiments | Proteins | Signal transduction | Cell activation | Gangrene | Immunoglobulins | Blood & organ donations | Leukocytes (eosinophilic) | Hypersensitivity | Esophagitis | MAP kinase | Rapamycin | Pharmacology | Electron microscopy | Adhesion | Asthma | Signaling | Microscopy | Granular materials | Protein kinase | Morphology | Degranulation | Granules | Skin | Leukocytes (granulocytic) | Phagocytosis | Apoptosis | Eosinophils
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 07/2019, Volume 189, Issue 7, pp. 1363 - 1374
Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation.... 
APOPTOSIS | NECROSIS | MEDIATOR | NECROTIC CELL-DEATH | MICE | ACETAMINOPHEN TOXICITY | PATHOLOGY | INFLAMMATORY RESPONSE | RIP3 | HEPATIC ISCHEMIA/REPERFUSION INJURY | FEEDBACK LOOP
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2013, Volume 23, Issue 8, pp. 994 - 1006
Journal Article
by He, W and Wang, Q and Srinivasan, B and Xu, J and Padilla, M.T and Li, Z and Wang, X and Liu, Y and Gou, X and Shen, H.-M and Xing, C and Lin, Y
Oncogene, ISSN 0950-9232, 06/2014, Volume 33, Issue 23, pp. 3004 - 3013
Killing cancer cells through the induction of apoptosis is one of the main mechanisms of chemotherapy. However, numerous cancer cells have primary or acquired... 
apoptosis | autophagy | RIP3 | c-IAP | RIP1 | necroptosis | INDUCED CELL-DEATH | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DOMAIN-LIKE | MECHANISMS | CELL BIOLOGY | RIPOPTOSOME | ONCOLOGY | DOWNSTREAM | GENETICS & HEREDITY | CYTOTOXICITY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Baculoviral IAP Repeat-Containing 3 Protein | Autophagy - drug effects | Gene Knockdown Techniques | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - genetics | Chalcones - pharmacology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Beclin-1 | Nuclear Pore Complex Proteins - metabolism | RNA, Small Interfering - pharmacology | Imidazoles - pharmacology | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Ubiquitin-Protein Ligases | Autophagy-Related Protein 7 | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA-Binding Proteins - metabolism | Autophagy (Cytology) | Chemotherapy | Physiological aspects | Health aspects | c-Jun N-terminal kinases | Apoptosis | Cancer | Biodegradation | Autophagy
Journal Article
Cancer, ISSN 0008-543X, 09/2013, Volume 119, Issue 17, pp. 3148 - 3155
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 11, pp. 2964 - 2969
Journal Article