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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 41, pp. E8788 - E8797
Dysfunction of microglia plays a fundamental role in the pathogenesis of Alzheimer’s disease (AD), the most common form of dementia. However, there is a lack... 
Inflammation | RIPK1 | Alzheimer’s disease | RIP1 | Microglia | Biological Sciences | PNAS Plus | inflammation | microglia
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 4, pp. 715 - 729.e5
TRAIL is a potent inducer of apoptosis and has been studied almost exclusively in this context. However, TRAIL can also induce NFκB-dependent expression of... 
Caspase-8 | NF-κB | TRAIL | cell death | apoptosis | cytokines | Inflammation | RIPK1 | FADDosome | death receptors
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1497 - 1501
Receptor-interacting protein kinase 1 (RIPK1), a key component of the cellular necroptosis pathway, has gained recognition as an important therapeutic target.... 
Metabolic stability | Pentafluoroethyl | RIPK1 | Necroptosis | RIPK1 inhibitor | RIP KINASES | HOMEOSTASIS | CHEMISTRY, MEDICINAL | INFLAMMATION | CHEMISTRY, ORGANIC | HIGHLY POTENT | DISCOVERY | International trade | Protein kinases | Analysis
Journal Article
The FEBS journal, ISSN 1742-464X, 7/2016, Volume 283, Issue 14, pp. 2616 - 2625
Journal Article
Antiviral Research, ISSN 0166-3542, 10/2019, Volume 170, p. 104588
Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide and can develop into chronic infection in immunocompromised patients,... 
NF-κB signaling | HEV | Caspase | RIPK1 | Deptropine
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2012, Volume 19, Issue 12, pp. 2003 - 2014
Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-known apoptosis inducer, we have previously demonstrated that acidic... 
RIPK1/RIPK3 | TRAIL | hepatitis | concanavalin A | colon cancer | necroptosis | APOPTOSIS | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | RECEPTOR | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | INFLAMMATION | NECROTIC CELL-DEATH | LIGAND | EXTRACELLULAR PH | T-CELLS | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | RNA Interference | Adenosine Triphosphate - metabolism | Killer Cells, Natural - immunology | Indoles - pharmacology | Hepatocytes - drug effects | Disease Models, Animal | Cell Line | Imidazoles - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Hep G2 Cells | HT29 Cells | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Hydrogen-Ion Concentration | RNA, Small Interfering - metabolism | Killer Cells, Natural | Poly(ADP-ribose) Polymerases | Reactive Oxygen Species | Receptor-Interacting Protein Serine-Threonine Kinases | Biochemistry, Molecular Biology | Adenosine Triphosphate | Life Sciences | Phenanthrenes | Imidazoles | TNF-Related Apoptosis-Inducing Ligand | Hepatocytes | RNA, Small Interfering | Indoles | Apoptosis | RIPK3 | Original Paper | RIPK1
Journal Article
Marine Drugs, ISSN 1660-3397, 06/2019, Volume 17, Issue 6, p. 362
Journal Article
Nature cell biology, ISSN 1465-7392, 12/2018, Volume 20, Issue 12, pp. 1330 - 1331
RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might... 
RIPK1 | PHOSPHORYLATION | INFLAMMATION | CELL BIOLOGY | Signal transduction | Inflammation | Cell death | Mortality | Apoptosis
Journal Article
ISSN 2041-4889, 2016
We previously reported that renal clear cell carcinoma cells (RCC) express both tumor necrosis factor receptor (TNFR)-1 and 2 but that in organ culture, a TNF... 
RCC | RIPK3 | TNFR2 | RIPK1 | TNFR1 | necroptosis
Journal Article
Autophagy, ISSN 1554-8627, 04/2019, Volume 15, Issue 4, pp. 744 - 746
Despite advances in HIV therapy, there is no cure, and lifelong antiretroviral treatment is required to suppress viral replication. We hypothesized that HIV... 
caspase 8 | CD4 | autophagy | HIV | T cell | SMAC mimetics | Fas | XIAP | RIPK1 | + | BIRC2 | Apoptosis
Journal Article
by Jiang, L and Liu, XQ and Ma, QY and Yang, Q and Gao, L and Li, HD and Wang, JN and Wei, B and Wen, JG and Li, J and Wu, YG and Meng, XM
FASEB JOURNAL, ISSN 0892-6638, 03/2019, Volume 33, Issue 3, pp. 3523 - 3535
MLKL is a central mediator for necroptosis. Its knockout significantly relieves acute kidney injury (AKI). However, its upstream regulatory mechanism in AKI... 
ACTIVATION | inflammation | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | miRNA | RIPK1 | DEATH | MICRORNAS | programmed cell death | exosome | PROTECTS | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 10/2015, Volume 2, Issue 4, p. e975093
Our current knowledge of the molecular mechanisms regulating the signaling pathways leading to cell survival, cell death, and inflammation has shed light on... 
crosstalk | tumor necrosis factor | RIPK3 | apoptosis | Fas | RIPK1 | FLIP | necroptosis
Journal Article