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Pharmacological Research, ISSN 1043-6618, 10/2019, Volume 148, p. 104439
The apoptosis alternate cell death pathways are extensively studied in recent years and their significance has been well recognized. With identification of... 
RIPK3 | MLKL | Necroptosis
Journal Article
Microbes and infection, ISSN 1286-4579, 08/2019
Receptor interacting protein kinase 3 (Ripk3) is a signal relay protein involved in initiation of programmed cell death (necroptosis) and modulation of... 
Journal Article
The FEBS journal, ISSN 1742-464X, 7/2016, Volume 283, Issue 14, pp. 2616 - 2625
Journal Article
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, ISSN 0022-1554, 04/2017, Volume 65, Issue 4, pp. 253 - 254
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 12941 - 12958
The disintegrin metalloprotease ADAM17 has a critical role in intestinal inflammation and regeneration in mice, as illustrated by the dramatically increased... 
ADAM17 | Colitis | RIPK3 | DSS | Necroptosis
Journal Article
BMB Reports, ISSN 1976-6696, 2016, Volume 49, Issue 6, p. 247
Necroptosis is a well-known form of caspase-independent cell death. Necroptosis can be triggered by various extrinsic stimuli, including death ligands in the... 
CHIP | RIPK3 | Necroptosis | Ubiquitylation | Lysosome
Journal Article
BMB Reports, ISSN 1976-6696, 2016, Volume 49, Issue 5, pp. 247 - 248
Necroptosis is a well-known form of caspase-independent cell death. Necroptosis can be triggered by various extrinsic stimuli, including death ligands in the... 
CHIP | RIPK3 | Necroptosis | Ubiquitylation | Lysosome
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2012, Volume 19, Issue 12, pp. 2003 - 2014
Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-known apoptosis inducer, we have previously demonstrated that acidic... 
RIPK1/RIPK3 | TRAIL | hepatitis | concanavalin A | colon cancer | necroptosis | APOPTOSIS | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | RECEPTOR | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | INFLAMMATION | NECROTIC CELL-DEATH | LIGAND | EXTRACELLULAR PH | T-CELLS | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | RNA Interference | Adenosine Triphosphate - metabolism | Killer Cells, Natural - immunology | Indoles - pharmacology | Hepatocytes - drug effects | Disease Models, Animal | Cell Line | Imidazoles - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Hep G2 Cells | HT29 Cells | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Hydrogen-Ion Concentration | RNA, Small Interfering - metabolism | Killer Cells, Natural | Poly(ADP-ribose) Polymerases | Reactive Oxygen Species | Receptor-Interacting Protein Serine-Threonine Kinases | Biochemistry, Molecular Biology | Adenosine Triphosphate | Life Sciences | Phenanthrenes | Imidazoles | TNF-Related Apoptosis-Inducing Ligand | Hepatocytes | RNA, Small Interfering | Indoles | Apoptosis | RIPK3 | Original Paper | RIPK1
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 13, pp. 3309 - 3319.e5
Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two... 
programmed necrosis | innate immunity | MLKL | RIPK3 | poxvirus | pseudokinase | necroptosis
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 10, pp. 2135 - 2144
Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during... 
Mitochondria | Pyroptosis | MLKL | RIPK3 | Necroptosis | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | CASPASE 8 | MOLECULAR SWITCH | AUTOPHAGY | TNF | CELL BIOLOGY | CYTOCHROME-C | TUMOR-NECROSIS-FACTOR | RIP3 | Autophagy - physiology | Animals | Apoptosis - physiology | Cell Death - physiology | Humans
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2019, Volume 79, Issue 7, pp. 1587 - 1599
Myeloid-derived suppressor cells (MDSC) promote colorectal cancer by several mechanisms, including suppression of antitumor T cells and production of... 
APOPTOSIS | ONCOLOGY | NECROPTOSIS ADAPTER RIPK3 | ROLES | MOUSE MODEL | SUPPRESSOR-CELLS | ACCUMULATION | TUMORIGENESIS | EXPRESSION | DEFICIENCY | TH17 CELLS
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 8, pp. 7902 - 7917
The antimicrobial peptide HPA3 shows anticancer activity in gastric cancer and leukaemia. However, how HPA3 exerts its anticancer activity, as well as whether... 
Antitumor activity | RIPK3 | Necroptosis | HPA3P | Peptide
Journal Article
ISSN 2041-4889, 2016
We previously reported that renal clear cell carcinoma cells (RCC) express both tumor necrosis factor receptor (TNFR)-1 and 2 but that in organ culture, a TNF... 
RCC | RIPK3 | TNFR2 | RIPK1 | TNFR1 | necroptosis
Journal Article
by Su, Z and Yang, Z and Xie, L and Dewitt, J.P and Chen, Y
Cell Death and Differentiation, ISSN 1350-9047, 05/2016, Volume 23, Issue 5, pp. 748 - 756
Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase... 
SHIKONIN | TRAIL | RIPK3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | MYELOID-LEUKEMIA CELLS | DEATH | DRUG-RESISTANCE | AUTOPHAGY | EXPRESSION | APOPTOSIS RESISTANCE | CELL BIOLOGY | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Apoptosis - drug effects | Humans | Necrosis | Neoplasms - drug therapy | Review
Journal Article
by Chen, YF and Wu, ZM and Luo, XJ and Bai, S and Zhao, LD
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, ISSN 1936-2625, 2018, Volume 11, Issue 2, pp. 568 - 568
Receptor-interacting serine-threonine kinase 3 (RIPk3) is a key signaling molecule in the regulation of cell apoptosis and necroptosis, it plays an important... 
APOPTOSIS | RIPK3 | NECROPTOSIS ADAPTER RIPK3 | KINASE 3 | PATHOLOGY | CELL-DEATH | PATHOGENESIS | gene knockout | mouse | hematopoiesis | NECROSIS | ONCOLOGY | RECEPTOR-INTERACTING PROTEIN | Bone marrow | CHRONIC LYMPHOCYTIC-LEUKEMIA | DIFFERENTIATION | APLASTIC-ANEMIA
Journal Article
BMB Reports, ISSN 1976-6696, 2015, Volume 48, Issue 6, p. 303
Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the "programmed", or "regulated" necrosis cell death pathway that is... 
Programmed Necrosis | RIPK3 | Hypomethylating agents | RIP3
Journal Article