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The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 06/2011, Volume 57, Issue 2, pp. 118 - 125
Journal Article
Clinical and Experimental Immunology, ISSN 0009-9104, 2016, Volume 184, Issue 2, pp. 159 - 173
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2007, Volume 356, Issue 15, pp. 1517 - 1526
The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets in type 2 diabetes, and high glucose concentrations induce interleukin-1β... 
INSULIN | MEDICINE, GENERAL & INTERNAL | HUMAN PANCREATIC-ISLETS | OBESITY | GLUCOSE | BETA-CELL APOPTOSIS | DISEASE | MUSCLE | EXPRESSION | RECEPTOR ANTAGONIST | NIDDM | Recombinant Proteins - therapeutic use | Insulin-Secreting Cells - secretion | Glucose Transporter Type 4 - metabolism | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Heat-Shock Proteins - genetics | Insulin Resistance - physiology | Interleukin-6 - blood | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Female | Interleukin 1 Receptor Antagonist Protein - pharmacology | Body Mass Index | Glucose Tolerance Test | Double-Blind Method | Glucose Transporter Type 4 - genetics | Heat-Shock Proteins - metabolism | C-Reactive Protein - secretion | Recombinant Proteins - pharmacology | Transcription Factors - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Insulin-Secreting Cells - drug effects | Interleukin 1 Receptor Antagonist Protein - adverse effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Type 2 diabetes | Interleukin-1 | Research | Drug therapy | Pancreas | Diabetes | Apoptosis | Index Medicus | Abridged Index Medicus | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2013, Volume 98, Issue 7, pp. 2783 - 2790
Context: Thyroid-associated ophthalmopathy (TAO) manifests as inflammation of orbital connective tissue. Bone marrow–derived CD34+ fibrocytes infiltrate the... 
CIGARETTE-SMOKING | PROTEIN | THYROTROPIN RECEPTOR | IFN-GAMMA | DISEASE | TISSUE | ENDOCRINOLOGY & METABOLISM | ENDOPEROXIDE H SYNTHASE-2 | IL-1-BETA | INDUCTION | GRAVES OPHTHALMOPATHY | Leukocytes - pathology | Fibroblasts - secretion | Antigens, CD34 - metabolism | Orbit - immunology | Graves Ophthalmopathy - surgery | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1alpha - metabolism | Orbit - surgery | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Cyclooxygenase 2 - biosynthesis | Leukocytes - immunology | Graves Ophthalmopathy - metabolism | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Cell Transdifferentiation | Interleukin 1 Receptor Antagonist Protein - secretion | Interleukin-1alpha - genetics | Interleukin-1beta - biosynthesis | Orbit - pathology | Fibroblasts - metabolism | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Disease Susceptibility | Cells, Cultured | Gene Expression Regulation | Fibroblasts - pathology | RNA Stability | Graves Ophthalmopathy - immunology | Orbit - metabolism | Cyclooxygenase 2 - metabolism | Fibroblasts - immunology | Interleukin-1alpha - biosynthesis | Leukocytes - secretion | Graves Ophthalmopathy - pathology | Leukocytes - metabolism | Index Medicus | Abridged Index Medicus | Endocrine Research
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2502 - 2514
Purpose: The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the... 
BREAST-CANCER | MULTIPLE-MYELOMA | APOPTOSIS | PHASE-II TRIAL | TANESPIMYCIN 17-AAG | TRASTUZUMAB | ONCOLOGY | BIM | ACQUIRED-RESISTANCE | MELANOMA-CELLS | POTENTIAL MECHANISM | Prospective Studies | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immunoenzyme Techniques | Forkhead Transcription Factors - metabolism | Colony-Forming Units Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phthalic Acids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins B-raf - metabolism | Membrane Proteins - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Forkhead Box Protein O3 | Azabicyclo Compounds - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2009, Volume 360, Issue 23, pp. 2426 - 2437
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2016, Volume 108, Issue 10, p. djw122