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Nature Medicine, ISSN 1078-8956, 05/2016, Volume 22, Issue 5, pp. 516 - 523
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Journal Article
Clinical and vaccine immunology, ISSN 1556-6811, 2006
Journal
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 12/2015, Volume 67, Issue 12, pp. 3234 - 3244
Objective To determine the relationships between systemic sclerosis (SSc)–related autoantibodies, as well as their clinical associations, in a... 
ANTIBODIES | ANTRAL VASCULAR ECTASIA | SUBSETS | CLASSIFICATION | PREVALENCE | RHEUMATOLOGY | JAPANESE PATIENTS | FRENCH | RNA-POLYMERASE-III | CLINICAL-SIGNIFICANCE | FEATURES | Receptors, Platelet-Derived Growth Factor - immunology | Gastric Antral Vascular Ectasia - immunology | Humans | Middle Aged | Centromere Protein B - immunology | Immunoblotting | Male | Raynaud Disease - etiology | DNA Topoisomerases, Type I - immunology | Esophageal Motility Disorders - etiology | Centromere Protein A | Scleroderma, Systemic - complications | Ribonucleoproteins - immunology | Female | Contracture - immunology | Gastric Antral Vascular Ectasia - etiology | Telangiectasis - immunology | Principal Component Analysis | DNA-Binding Proteins - immunology | Exoribonucleases - immunology | RNA-Binding Proteins - immunology | Scleroderma, Systemic - immunology | RNA Polymerase III - immunology | Scleroderma, Systemic - epidemiology | Chromosomal Proteins, Non-Histone - immunology | Autoantibodies - immunology | Ku Autoantigen | Telangiectasis - etiology | Smoking - epidemiology | Autoantigens - immunology | Sex Factors | Aged | Exosome Multienzyme Ribonuclease Complex - immunology | Pol1 Transcription Initiation Complex Proteins - immunology | Raynaud Disease - immunology | Australia | Esophageal Motility Disorders - immunology | Antigens, Nuclear - immunology | Neoplasms - epidemiology | Cohort Studies | Contracture - etiology | Principal components analysis | RNA polymerase | Autoimmune diseases | Patients
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 123 - 135
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin-18 (IL-18) and IL-1β.... 
DOUBLE-STRANDED-RNA | ANTIVIRAL RESPONSES | INTRACELLULAR DNA | DENDRITIC CELLS | RECOGNITION | BACTERIAL RNA | CASPASE-1 | INDUCIBLE GENE-I | RIG-I | IMMUNOLOGY | CYTOPLASMIC DNA | Interleukin-18 - immunology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Humans | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | RNA - genetics | RNA Interference | Interleukin-1beta - metabolism | Gene Expression - immunology | HEK293 Cells | Poly I-C - immunology | RNA, Double-Stranded - metabolism | DEAD-box RNA Helicases - metabolism | Carrier Proteins - immunology | Macrophages - immunology | RNA - metabolism | Cell Line | RNA - immunology | Macrophage Activation - immunology | Interleukin-1beta - immunology | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Inflammasomes - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Microscopy, Confocal | Macrophages - metabolism | Carrier Proteins - metabolism | Inflammasomes - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | DEAD-box RNA Helicases - immunology | RNA, Bacterial - immunology | Cytosol - metabolism | RNA, Viral - immunology | Interleukin-18 - metabolism | RNA | Biological response modifiers | Proteins | Immunology | Laboratories | Glycerol | Infections | Sensors | Viral infections | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 12/2016, Volume 12, Issue 12, pp. 716 - 730
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5418 - 5427
IFN-beta-1a has been used over the past 15 years as a primary therapy for relapsing-remitting multiple sclerosis (MS). However, the immunomodulatory mechanisms... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | GROWTH-FACTOR-BETA | T(H)17 CELLS | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MESSENGER-RNA EXPRESSION | CENTRAL-NERVOUS-SYSTEM | INTERFERON-BETA | IMMUNOLOGY | UP-REGULATION | T-CELLS | Receptors, CCR6 - immunology | Interleukin-12 Subunit p35 - metabolism | Interleukin-23 Subunit p19 - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Receptors, CCR6 - antagonists & inhibitors | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin - metabolism | Interleukin-23 Subunit p19 - metabolism | STAT1 Transcription Factor - metabolism | Interleukin-1beta - metabolism | Receptors, Retinoic Acid - immunology | Phosphorylation - immunology | Phosphorylation - drug effects | Receptors, Thyroid Hormone - immunology | Interleukin-1beta - antagonists & inhibitors | Nuclear Receptor Subfamily 1, Group F, Member 3 | Receptors, Interleukin - immunology | Receptors, Interleukin - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | Cell Differentiation - immunology | Interferon beta-1a | Up-Regulation - immunology | Interleukin-23 Subunit p19 - immunology | STAT3 Transcription Factor - immunology | Interleukin-10 - immunology | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | T-Lymphocytes, Helper-Inducer - drug effects | T-Lymphocytes, Helper-Inducer - immunology | Receptors, CCR6 - metabolism | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Interleukin-10 - agonists | STAT3 Transcription Factor - metabolism | Cells, Cultured | Interleukin-1beta - immunology | Interleukin-12 Subunit p35 - agonists | Down-Regulation - drug effects | STAT1 Transcription Factor - immunology | Receptors, Thyroid Hormone - metabolism | Up-Regulation - drug effects | Interferon-beta - pharmacology | Interleukin-12 Subunit p35 - immunology | Cell Differentiation - drug effects | Down-Regulation - immunology | STAT3 Transcription Factor - drug effects | Multiple Sclerosis - immunology | CD4-Positive T-Lymphocytes - drug effects
Journal Article