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Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7322, pp. 452 - 456
Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated at the N-7 and 2′-O positions of the 5′ guanosine cap by specific nuclear... 
METHYLTRANSFERASE | INITIATION | MULTIDISCIPLINARY SCIENCES | GENES | ALPHA | NILE-VIRUS-INFECTION | INDUCTION | PROTEINS | TRANSLATION | IDENTIFICATION | PROTECTS | Poxviridae - genetics | RNA Caps - immunology | Humans | Methyltransferases - metabolism | Immunity, Innate - genetics | Protein Biosynthesis - immunology | Interferons - immunology | Neoplasm Proteins - metabolism | RNA Caps - metabolism | RNA, Viral - genetics | West Nile virus - genetics | Fibroblasts | Poxviridae - physiology | RNA, Viral - metabolism | Receptor, Interferon alpha-beta - genetics | Interferons - genetics | Neoplasm Proteins - genetics | Coronavirus - physiology | RNA Caps - genetics | West Nile virus - physiology | Poxviridae - enzymology | West Nile virus - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Cells, Cultured | Survival Rate | Poxviridae - immunology | Interferons - deficiency | Coronavirus - immunology | Proteins - genetics | Carrier Proteins - genetics | Immunity, Innate - immunology | Models, Immunological | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Virus Replication | Coronavirus - genetics | RNA, Viral - immunology | West Nile virus - enzymology | Mice | Models, Genetic | Coronavirus - enzymology | Methylation | 3T3 Cells | West Nile fever | Interferon | Messenger RNA | Methyltransferases | Mortality | Viruses | Infections | Pattern recognition | Experiments | Viral infections | Cytoplasm | Evacuations & rescues | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 1, pp. 9 - 21.e7
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2010, Volume 6, Issue 9, pp. e1001101 - e1001101
Bunyaviruses are a large family of segmented RNA viruses which, like influenza virus, use a cap-snatching mechanism for transcription whereby short capped... 
PA SUBUNIT | MAXIMUM-LIKELIHOOD | ACTIVE-SITE | METAL-BINDING | MICROBIOLOGY | COMPLETE NUCLEOTIDE-SEQUENCE | MESSENGER-RNAS | VIROLOGY | HIV-1 INTEGRASE | GENUS TENUIVIRUS | 5' ENDS | VIRUS L-SEGMENT | PARASITOLOGY | Endonucleases - genetics | Phenylbutyrates | Bunyaviridae Infections - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Endonucleases - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Viral Proteins - metabolism | Orthomyxoviridae - immunology | Bunyaviridae - genetics | RNA, Viral - genetics | Bunyaviridae - enzymology | Bunyaviridae Infections - genetics | Influenza, Human - virology | Transcription, Genetic | DNA-Directed RNA Polymerases - chemistry | RNA, Viral - metabolism | RNA Caps - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Catalytic Domain | Viral Proteins - chemistry | RNA, Messenger - genetics | Crystallization | Orthomyxoviridae - metabolism | Viral Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Aminobutyrates - metabolism | Endonucleases - chemistry | Sequence Homology, Amino Acid | Bunyaviridae Infections - virology | Influenza, Human - genetics | Orthomyxoviridae - genetics | DNA-Directed RNA Polymerases - metabolism | Influenza viruses | Proteins | Genetic aspects | Research | Properties | Structure | RNA polymerases | Index Medicus | Enzymes | RNA | Plasmids | Ribonucleic acid
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2011, Volume 30, Issue 12, pp. 2325 - 2335
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in... 
hippo signalling | F‐actin | growth regulation | F-actin | TISSUE-GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | YORKIE PHOSPHORYLATION | TEAD/TEF FAMILY | CELL BIOLOGY | REGULATE CELL-PROLIFERATION | SIGNALING PATHWAY | GENE-EXPRESSION | CONTACT INHIBITION | SIZE-CONTROL | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Wings, Animal - cytology | Cell Proliferation | Humans | Drosophila melanogaster - genetics | Actins - genetics | Drosophila Proteins - biosynthesis | Organ Specificity - genetics | Wings, Animal - growth & development | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Actins - chemistry | RNA Caps - antagonists & inhibitors | RNA Caps - chemistry | Intracellular Signaling Peptides and Proteins - genetics | Cytoskeleton - chemistry | RNA Caps - genetics | Actins - biosynthesis | Carrier Proteins - biosynthesis | Cells, Cultured | Cytoskeleton - genetics | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Drosophila Proteins - chemistry | Carrier Proteins - genetics | Phenotype | Animals | Drosophila melanogaster - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Wings, Animal - chemistry | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | HeLa Cells | Proteins | Signal transduction | Tumors | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 1, pp. 22 - 37.e9
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 29, Issue 2, pp. 169 - 179
The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by... 
RNA | MOLIMMUNO | RESPONSES | HELICASE LGP2 | VIRUS | ACID | REPLICATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIVIRAL INNATE IMMUNITY | HOST | IDENTIFICATION | ADAPTER PROTEIN | CELL BIOLOGY | RNA Caps - immunology | RNA Helicases - metabolism | Zinc - metabolism | Humans | rab GTP-Binding Proteins - genetics | Structure-Activity Relationship | RNA Helicases - chemistry | Interferons - immunology | RNA Caps - metabolism | Zinc - chemistry | Adenosine Triphosphatases - immunology | Interferon-Induced Helicase, IFIH1 | RNA, Viral - genetics | Immunity, Innate - physiology | RNA Caps - chemistry | Zinc - immunology | RNA Helicases - genetics | RNA, Viral - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Dimerization | RNA Caps - genetics | rab GTP-Binding Proteins - metabolism | Cell Line | DEAD Box Protein 58 | Adenosine Triphosphatases - metabolism | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Substrate Specificity - genetics | Polyphosphates - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Viral - chemistry | Polyphosphates - immunology | rab GTP-Binding Proteins - immunology | DEAD-box RNA Helicases - immunology | Interferons - metabolism | Adenosine Triphosphatases - chemistry | RNA, Viral - immunology | rab GTP-Binding Proteins - chemistry | Adenosine Triphosphatases - genetics | Structural Homology, Protein | RNA Helicases - immunology | Polyphosphates - chemistry | Sensors | G proteins | Biological response modifiers | Adenosine triphosphatase | Index Medicus
Journal Article
Nature methods, ISSN 1548-7091, 03/2006, Volume 3, Issue 3, pp. 211 - 222
Transcript abundance can be determined by various methods, including reverse transcription (RT)-PCR, microarray analysis, sequencing of expressed sequence tags... 
LENGTH CDNA CLONING | TRANSCRIPTOME | SERIAL ANALYSIS | ANNOTATION | GENOME | BIOCHEMICAL RESEARCH METHODS | Animals | Gene Library | Humans | DNA, Complementary - genetics | DNA, Complementary - biosynthesis | Gene Expression Profiling - methods | Mice | Transcription, Genetic - genetics | Promoter Regions, Genetic - genetics | RNA Caps - genetics
Journal Article
Nature Protocols, ISSN 1754-2189, 03/2012, Volume 7, Issue 3, pp. 542 - 561
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2011, Volume 208, Issue 9, pp. 1799 - 1807
New anticancer drugs that target oncogenic signaling molecules have greatly improved the treatment of certain cancers. However, resistance to targeted... 
MEDICINE, RESEARCH & EXPERIMENTAL | B-CELL LYMPHOMA | HODGKINS-LYMPHOMA | THERAPY | INITIATION | LEUKEMIA | IMMUNOLOGY | EXPRESSION | CANCER | EIF4E | TUMORIGENESIS | TRANSGENIC MICE | Gene Expression Regulation, Enzymologic - drug effects | Protein Biosynthesis | Antibiotics, Antineoplastic - pharmacology | Humans | Multiprotein Complexes | Proto-Oncogene Proteins c-pim-1 - metabolism | RNA Caps - metabolism | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Lymphoma - metabolism | Lymphoma - drug therapy | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - metabolism | RNA Caps - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Lymphoma - genetics | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Sirolimus - pharmacology | Proteins - genetics | Transcription Factors - metabolism | Drug Resistance, Neoplasm - genetics | Animals | Proteins - metabolism | Gene Expression Regulation, Enzymologic - genetics | Proto-Oncogene Proteins c-pim-1 - genetics | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Drug Resistance, Neoplasm - drug effects | Index Medicus | Brief Definitive Report
Journal Article