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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15181 - 15186
Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in plasmacytoid dendritic cells (pDCs). Previous studies suggest the... 
RNA | Dendritic cells | DNA | Cell lines | Antivirals | Antibodies | Small interfering RNA | Innate immunity | Cellular immunity | Sensors | Cytosolic sensor | VIRUS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | CYTOSOLIC DNA | ALPHA | INDUCTION | cytosolic sensor | innate immunity | PATHWAY | INFECTION | ADAPTER PROTEIN | RNA, Small Interfering - genetics | Dendritic Cells - immunology | Humans | Neoplasm Proteins - antagonists & inhibitors | Phylogeny | Neoplasm Proteins - metabolism | DEAD-box RNA Helicases - antagonists & inhibitors | Base Sequence | B-Lymphocytes - virology | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Neoplasm Proteins - genetics | Binding Sites | DEAD-box RNA Helicases - chemistry | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B p50 Subunit - metabolism | Signal Transduction | DNA, Viral - metabolism | Neoplasm Proteins - chemistry | Immunity, Innate | Interferon Regulatory Factor-7 - metabolism | Receptors, Transferrin - metabolism | DEAD-box RNA Helicases - genetics | B-Lymphocytes - immunology | CpG Islands | Myeloid Differentiation Factor 88 - metabolism | Natural immunity | Genetic aspects | Research | Biological response modifiers | Properties | Binding proteins | Human immunogenetics | Phosphates | Amino acids | Cytokines | Ribonucleic acid--RNA | Neurons | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 29, Issue 2, pp. 169 - 179
The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by... 
RNA | MOLIMMUNO | RESPONSES | HELICASE LGP2 | VIRUS | ACID | REPLICATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIVIRAL INNATE IMMUNITY | HOST | IDENTIFICATION | ADAPTER PROTEIN | CELL BIOLOGY | RNA Caps - immunology | RNA Helicases - metabolism | Zinc - metabolism | Humans | rab GTP-Binding Proteins - genetics | Structure-Activity Relationship | RNA Helicases - chemistry | Interferons - immunology | RNA Caps - metabolism | Zinc - chemistry | Adenosine Triphosphatases - immunology | Interferon-Induced Helicase, IFIH1 | RNA, Viral - genetics | Immunity, Innate - physiology | RNA Caps - chemistry | Zinc - immunology | RNA Helicases - genetics | RNA, Viral - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Dimerization | RNA Caps - genetics | rab GTP-Binding Proteins - metabolism | Cell Line | DEAD Box Protein 58 | Adenosine Triphosphatases - metabolism | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Substrate Specificity - genetics | Polyphosphates - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Viral - chemistry | Polyphosphates - immunology | rab GTP-Binding Proteins - immunology | DEAD-box RNA Helicases - immunology | Interferons - metabolism | Adenosine Triphosphatases - chemistry | RNA, Viral - immunology | rab GTP-Binding Proteins - chemistry | Adenosine Triphosphatases - genetics | Structural Homology, Protein | RNA Helicases - immunology | Polyphosphates - chemistry | Sensors | G proteins | Biological response modifiers | Adenosine triphosphatase | Index Medicus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6126, pp. 1436 - 1441
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears... 
Proteins | Protein isoforms | Phosphorylation | Messenger RNA | RNA | HEK293 cells | REPORTS | Small interfering RNA | HeLa cells | Fibroblast growth factors | Embryos | PROTEIN | WNT/BETA-CATENIN | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | I-EPSILON | C-ELEGANS | MUTATIONS | INDUCTION | MEDULLOBLASTOMA | PROMOTES | FAMILY | RNA Helicases - metabolism | Xenopus Proteins - genetics | Xenopus - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | RNA Helicases - chemistry | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Xenopus - embryology | Xenopus Proteins - chemistry | Casein Kinase Iepsilon - chemistry | Casein Kinase Iepsilon - metabolism | HEK293 Cells | RNA Helicases - genetics | DEAD-box RNA Helicases - metabolism | Dishevelled Proteins | DEAD-box RNA Helicases - chemistry | Wnt Signaling Pathway | Protein Structure, Tertiary | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | beta Catenin - metabolism | DEAD-box RNA Helicases - genetics | Animals | Xenopus - metabolism | Protein Binding | Xenopus Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Caenorhabditis elegans Proteins - genetics | Index Medicus | Pathways | Ribonucleic acids | Asymmetry | Genes | Division | Kinases | Gene expression
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2017, Volume 36, Issue 11, pp. 1590 - 1604
The superfamily 1B ( SF 1B) helicase Sen1 is an essential protein that plays a key role in the termination of non‐coding transcription in yeast. Here, we... 
non‐coding transcription | helicases | RNA | transcription termination | RNA helicases | non-coding transcription | RNA-POLYMERASE-II | PROTEIN | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBOSOMAL-RNA | HUMAN UPF1 | CELL BIOLOGY | HUMAN SENATAXIN | SACCHAROMYCES-CEREVISIAE SEN1 | DNA HELICASE | MOLECULAR-BASIS | Gene Expression Regulation, Fungal | RNA Folding | DNA Helicases - chemistry | RNA Helicases - metabolism | Mutant Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Mutant Proteins - metabolism | RNA Helicases - chemistry | Saccharomyces cerevisiae Proteins - genetics | RNA, Messenger - metabolism | DNA Helicases - metabolism | DNA Mutational Analysis | Mutant Proteins - chemistry | Transcription Termination, Genetic | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Conformation | RNA Helicases - genetics | Nucleic Acid Conformation | DNA Helicases - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cerebellum | Yeast | Cerebellar ataxia | Unwinding | Saccharomyces | Mimicry | Proteins | Transcription termination | DNA helicase | Ribonucleic acids | Ataxia | Mutation | Catalysis | Saccharomyces cerevisiae | In vitro methods and tests | Crystal structure | RNA helicase | Structural analysis | Index Medicus | RNA Biology | Structural Biology
Journal Article