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Science, ISSN 0036-8075, 4/2012, Volume 336, Issue 6079, pp. 315 - 319
A detailed understanding of the mechanisms that underlie antibiotic killing is important for the derivation of new classes of antibiotics and clinically useful... 
RESEARCH ARTICLE | Antibiotics | Cell death | DNA | Fluorescence | Cytotoxicity | Oxidation | Nucleotides | Overproduction | Genetic mutation | Guanine nucleotides | MUTAGENESIS | PROTEIN | REPLICATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | DOUBLE-STRAND BREAKS | HYDROGEN-PEROXIDE | MECHANISMS | MUTT-TYPE ENZYME | DNA-POLYMERASES | DAMAGE | Guanine Nucleotides - metabolism | DNA, Bacterial - metabolism | Guanine - analogs & derivatives | Escherichia coli - drug effects | Pyrophosphatases - genetics | DNA Polymerase II - metabolism | DNA Breaks, Double-Stranded | DNA-Directed DNA Polymerase - genetics | Guanine - metabolism | Norfloxacin - pharmacology | Escherichia coli - metabolism | Ampicillin - pharmacology | Deoxyguanine Nucleotides - metabolism | DNA Polymerase beta - metabolism | DNA Polymerase I - genetics | DNA Polymerase II - genetics | DNA Polymerase beta - genetics | RNA, Bacterial - metabolism | DNA Glycosylases - metabolism | Oxidation-Reduction | DNA Glycosylases - genetics | Escherichia coli Proteins - metabolism | Hydroxyl Radical - metabolism | Microbial Viability | Kanamycin - pharmacology | Pyrophosphatases - metabolism | Escherichia coli - genetics | Models, Biological | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | DNA-Directed DNA Polymerase - metabolism | DNA Polymerase I - metabolism | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Guanine | Drug therapy
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