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Molecular Cell, ISSN 1097-2765, 11/2012, Volume 48, Issue 3, pp. 409 - 421
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the degradation of short-lived noncoding RNAs, and in the quality control of RNAs... 
II TRANSCRIPTS | RAPID TRANSFER-RNA | OXIDATIVE STRESS | MATURE TRANSFER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A) POLYMERASE | QUALITY-CONTROL | RIBOSOMAL-RNA | SACCHAROMYCES-CEREVISIAE | BIDIRECTIONAL PROMOTERS | NUCLEAR EXOSOME | CELL BIOLOGY | Introns - genetics | Oligonucleotide Array Sequence Analysis | RNA Processing, Post-Transcriptional | RNA, Transfer - metabolism | Saccharomyces cerevisiae - genetics | RNA, Ribosomal - metabolism | Substrate Specificity | RNA Precursors - genetics | Gene Expression Profiling | Saccharomyces cerevisiae Proteins - genetics | RNA, Ribosomal - genetics | RNA, Small Nucleolar - genetics | RNA, Fungal - metabolism | Saccharomyces cerevisiae - metabolism | Blotting, Northern | RNA, Small Nucleolar - metabolism | Saccharomyces cerevisiae Proteins - metabolism | RNA, Transfer - genetics | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Precursors - metabolism | RNA, Fungal - genetics | Mutation | Exosome Multienzyme Ribonuclease Complex - genetics | Analysis | Transfer RNA | Index Medicus | RNA Precursors | Introns | Quantitative Methods | Biochemistry, Molecular Biology | Genomics | Cellular Biology | RNA, Transfer | Bacteriology | Life Sciences | Microbiology and Parasitology | RNA, Ribosomal | RNA, Small Nucleolar | Saccharomyces cerevisiae Proteins | RNA, Fungal | Subcellular Processes | Exosome Multienzyme Ribonuclease Complex | Molecular biology | Saccharomyces cerevisiae
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7600, pp. 517 - 521
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease | Index Medicus
Journal Article