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Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5772 - 5781
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress, which is adaptively managed by... 
SURVIVAL | CELLS | IN-VITRO | UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | BONE-MARROW | ENDOPLASMIC-RETICULUM STRESS | IDENTIFICATION | HEMATOLOGY | TRANSCRIPTION FACTOR | eIF-2 Kinase - metabolism | Humans | Pyrazines - therapeutic use | Endoribonucleases - antagonists & inhibitors | Boronic Acids - therapeutic use | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Multiple Myeloma - drug therapy | Enzyme Inhibitors - chemistry | RNA Splicing - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Death - drug effects | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Unfolded Protein Response - drug effects | Bortezomib | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Bone Marrow Cells - cytology | RNA, Messenger - genetics | Stromal Cells - metabolism | Enzyme Inhibitors - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Lactams, Macrocyclic - pharmacology | Enzyme Inhibitors - therapeutic use | Regulatory Factor X Transcription Factors | Benzoquinones - pharmacology | Multiple Myeloma - pathology | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pyrazines - pharmacology | Bone Marrow Cells - metabolism | Multiple Myeloma - genetics | Stromal Cells - cytology | Boronic Acids - pharmacology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
The Plant Cell, ISSN 1040-4651, 11/2007, Volume 19, Issue 11, pp. 3437 - 3450
The most widespread riboswitch class, found in organisms from all three domains of life, is responsive to the vitamin B₁ derivative thiamin pyrophosphate... 
Untranslated regions | Messenger RNA | RNA | Splicing | Reverse transcriptase polymerase chain reaction | Five prime untranslated regions | Introns | Nucleotides | Three prime untranslated regions | Gene expression | BINDING RNA | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYADENYLATION | BOX | IDENTIFICATION | PLANT SCIENCES | CELL BIOLOGY | ELEMENTS | COMPARATIVE GENOMICS | STRUCTURAL BASIS | BIOSYNTHESIS | ARABIDOPSIS | Thiamine Pyrophosphate - metabolism | 3' Untranslated Regions - genetics | Molecular Sequence Data | 3' Untranslated Regions - chemistry | RNA 3' End Processing - drug effects | Plants - genetics | Base Sequence | Conserved Sequence | Plant Proteins - metabolism | Thiamine - pharmacology | Regulatory Sequences, Ribonucleic Acid - genetics | Introns - genetics | Alternative Splicing - genetics | RNA, Messenger - genetics | Aptamers, Nucleotide - chemistry | Exons - genetics | Nucleic Acid Conformation - drug effects | Plants - drug effects | Mutation - genetics | Aptamers, Nucleotide - genetics | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Alternative Splicing - drug effects | Feedback, Physiological - drug effects | Models, Genetic | RNA 3' End Processing - genetics | Physiological aspects | Evaluation | Thiamine pyrophosphate | RNA splicing | Index Medicus | s
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Proteins | Molecules | Membranes | Ribonucleic acid--RNA | Cells | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2018, Volume 24, Issue 4, pp. 497 - 504
Journal Article
Circulation, ISSN 0009-7322, 04/2013, Volume 127, Issue 16, pp. 1712 - 1722
Background-Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding... 
endothelial cells | signal transduction | angiogenesis | ischemia | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ER STRESS | ATHEROSCLEROSIS | PROLIFERATION | ENDOPLASMIC-RETICULUM STRESS | VEIN GRAFTS | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | PERIPHERAL VASCULAR DISEASE | MICE | TRANSCRIPTION FACTOR ATF6 | Genetic Therapy | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Transcription Factors - deficiency | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | RNA, Messenger - biosynthesis | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | Vascular Endothelial Growth Factor Receptor-2 - agonists | Vascular Endothelial Growth Factor Receptor-2 - physiology | Phosphorylation - drug effects | Vascular Endothelial Growth Factor A - pharmacology | RNA Splicing - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Endoplasmic Reticulum Stress - drug effects | Endothelial Cells - metabolism | Embryo, Mammalian - blood supply | RNA, Messenger - genetics | Hematopoietic Stem Cell Transplantation | Ischemia - therapy | Radiation Chimera | Retinal Vessels - drug effects | Ischemia - physiopathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Mice, Knockout | Neovascularization, Physiologic - physiology | Animals | Leg - blood supply | Retinal Vessels - growth & development | Mice | Protein Kinase Inhibitors - pharmacology | Aorta - cytology | Vascular Endothelial Growth Factor A - physiology | Endoplasmic Reticulum Stress - physiology | Endothelial Cells - drug effects | Cell proliferation | Physiological aspects | Cellular signal transduction | Research | Neovascularization | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 672 - 678
Journal Article
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. eaal3755 - eaal3755
Journal Article