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Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 318 - 323
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron... 
2ND STEP | I SPLICEOSOME | U4/U6.U5 TRI-SNRNP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | CATALYTIC CORE | PRE-MESSENGER-RNA | PRP8 | INSIGHTS | Spliceosomes - chemistry | Humans | Cell Cycle Proteins - ultrastructure | RNA Splicing Factors - chemistry | RNA, Messenger - metabolism | RNA Splicing Factors - metabolism | Cell Cycle Proteins - chemistry | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | Base Sequence | Protein Domains | Ribonucleoproteins, Small Nuclear - chemistry | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Biocatalysis | Introns - genetics | Movement | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Exons - genetics | Spliceosomes - ultrastructure | RNA Stability | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Adenosine - metabolism | Saccharomyces cerevisiae - enzymology | RNA, Messenger - chemistry | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Ribonuclease H - metabolism | Genetic research | Genetic engineering | Research | Methods | RNA splicing | Proteins | Yeast | Catalysis | Molecular structure | Microscopy | Ribonucleic acid--RNA
Journal Article
Science, ISSN 0036-8075, 01/2017, Volume 355, Issue 6321, pp. 149 - 155
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15522
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 377 - 380
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications-branching and exon ligation(1)-catalysed at a single catalytic metal site... 
2ND STEP | ANGSTROM RESOLUTION | ELECTRON CRYOMICROSCOPY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL INTERACTIONS | CATALYTIC CENTER | CRYO-EM STRUCTURE | SPLICING FACTOR | SITE CHOICE | PRE-MESSENGER-RNA | RNA Helicases - metabolism | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Cell Cycle Proteins - ultrastructure | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - ultrastructure | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | RNA, Small Nuclear - genetics | Protein Domains | Ribonucleoprotein, U5 Small Nuclear - ultrastructure | Adenosine Triphosphatases - ultrastructure | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | RNA Splice Sites - genetics | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | Exons - genetics | Spliceosomes - ultrastructure | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | DNA-Binding Proteins - ultrastructure | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Protein Binding | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | RNA sequencing | Methods | Mutation | Catalysis | Ribonucleic acid--RNA | Binding sites | Crystal structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18240 - 18255
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 307 - 319
SF3b is a heptameric protein complex of the U2 small nuclear ribonucleoprotein (snRNP) that is essential for pre-mRNA splicing. Mutations in the largest SF3b... 
crystal structure | U2AF65 | SF3b | SF3B1 | cancer-related mutations | pre-mRNA splicing | DNA-DAMAGE RECOGNITION | SITE | U2 SNRNP PROTEINS | COMPLEX | U2AF | BRANCH POINT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | BINDING | PRE-MESSENGER-RNA | CELL BIOLOGY | Oncogene Proteins - genetics | Spliceosomes - chemistry | Baculoviridae - metabolism | Humans | Baculoviridae - genetics | Crystallography, X-Ray | RNA Splicing Factors - chemistry | Moths | Neoplasm Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Protein Subunits - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Cloning, Molecular | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Binding Sites | Genes, Tumor Suppressor | Protein Subunits - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Recombinant Proteins - genetics | Spliceosomes - ultrastructure | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Splicing Factor U2AF - genetics | Animals | Protein Conformation, beta-Strand | Protein Binding | Splicing Factor U2AF - chemistry | Protein Subunits - chemistry | HeLa Cells | Mutation | Splicing Factor U2AF - metabolism | Crosslinked polymers | RNA | Crystals | Genetic aspects | Structure | Binding proteins | Mass spectrometry | Cancer | Protein binding
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, pp. 617 - 621
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome's catalytic centre. Here we... 
U4/U6.U5 TRI-SNRNP | COMPLEX | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | U2 SNRNP | CRYO-EM STRUCTURE | REQUIRES ATP | RNA Helicases - metabolism | Ribonucleoprotein, U2 Small Nuclear - chemistry | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoprotein, U2 Small Nuclear - metabolism | Base Sequence | Protein Domains | RNA Precursors - metabolism | Ribonucleoproteins, Small Nuclear - chemistry | Protein Stability | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | Introns - genetics | RNA Splice Sites - genetics | Models, Molecular | Nuclear Proteins - metabolism | RNA Precursors - genetics | Spliceosomes - ultrastructure | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Yeast | Ribonucleoproteins (small nuclear) | Molecular structure | mRNA | Saccharomyces | Ribonucleoproteins (U2 small nuclear) | Electron microscopy | Ribonucleic acid--RNA | snRNA | Proteins | DNA helicase | Transmission electron microscopy | Ribonucleic acids | Catalysis | Atomic structure | Saccharomyces cerevisiae
Journal Article