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1. Full Text Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
by Geary, Richard S and Norris, Daniel and Yu, Rosie and Bennett, C. Frank
Advanced Drug Delivery Reviews, ISSN 0169-409X, 06/2015, Volume 87, pp. 46 - 51
Pharmacokinetic properties of oligonucleotides are largely driven by chemistry of the backbone and thus are sequence independent within a chemical class.... 
Cell uptake | Oligonucleotide | Pharmacokinetics | Biodistribution | RNA | MECHANISMS | SUPPRESSION | REDUCTION | PHARMACOLOGY | DISEASE | LIVER | PHARMACOLOGY & PHARMACY | MICE | EXPRESSION | 2ND-GENERATION | Injections, Spinal | Neoplasms - metabolism | Injections, Intravenous | Species Specificity | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Blood Proteins - metabolism | Organ Specificity | Neoplasms - drug therapy | Tissue Distribution | Endocytosis | Animals | Biological Transport | Injections, Subcutaneous | Oligonucleotides, Antisense - therapeutic use | Drug Design | Protein Binding | Oligonucleotides, Antisense - administration & dosage | Sulfur compounds | Protein binding | Blood proteins
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2. Full Text RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
by Bennett, C. Frank and Swayze, Eric E
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 02/2010, Volume 50, Issue 1, pp. 259 - 293
Dramatic advances in understanding of the roles RNA plays in normal health and disease have greatly expanded over the past 10 years and have made it clear that... 
Antisense oligonucleotides | RNase H | RNA interference | RNA | RNA splicing | PEPTIDE NUCLEIC-ACIDS | CYTOSOLIC MALATE-DEHYDROGENASE | IMPROVED IN-VITRO | PLASMA-PROTEIN BINDING | MAMMALIAN-CELLS | PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | SMALL INTERFERING RNA | DENSITY-LIPOPROTEIN CHOLESTEROL | antisense oligonucleotides | CHRONIC LYMPHOCYTIC-LEUKEMIA | TOXICOLOGY | GLOBIN MESSENGER-RNA | RNA - physiology | Animals | Oligonucleotides, Antisense - pharmacology | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - therapeutic use | Oligonucleotides, Antisense - chemistry | Physiological aspects | Research | Ribonuclease | Oligonucleotides
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3. Full Text miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
by Hansen, Thomas B and Wiklund, Erik D and Bramsen, Jesper B and Villadsen, Sune B and Statham, Aaron L and Clark, Susan J and Kjems, Jørgen
The EMBO Journal, ISSN 0261-4189, 11/2011, Volume 30, Issue 21, pp. 4414 - 4422
MicroRNAs (miRNAs) are ∼22 nt non‐coding RNAs that typically bind to the 3′ UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and... 
nuclear microRNA | miR‐671 | natural antisense transcript | circular RNA | CDR1 | miR-671 | CANCER-CELLS | DNA METHYLATION | HUMAN-CELLS | LET-7 MICRORNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | CELL BIOLOGY | NONCODING RNA | MESSENGER-RNAS | EXPRESSION | NEOPLASTIC CEREBELLAR DEGENERATION | INTERFERING RNAS | RNA Interference - drug effects | Autoantigens - metabolism | Humans | Molecular Sequence Data | RNA Cleavage - physiology | Autoantigens - genetics | MicroRNAs - pharmacology | RNA Splicing - physiology | Base Sequence | RNA Splicing - genetics | RNA, Antisense - chemistry | HEK293 Cells | Argonaute Proteins - physiology | Nucleic Acid Conformation | RNA - metabolism | Argonaute Proteins - metabolism | Gene Expression Regulation - genetics | RNA - drug effects | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | RNA Cleavage - drug effects | RNA Cleavage - genetics | Models, Biological | RNA, Antisense - metabolism | MicroRNAs - physiology | Proteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Molecular biology | Index Medicus
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4. Full Text Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice
by Prakash, Thazha P and Graham, Mark J and Yu, Jinghua and Carty, Rick and Low, Audrey and Chappell, Alfred and Schmidt, Karsten and Zhao, Chenguang and Aghajan, Mariam and Murray, Heather F and Riney, Stan and Booten, Sheri L and Murray, Susan F and Gaus, Hans and Crosby, Jeff and Lima, Walt F and Guo, Shuling and Monia, Brett P and Swayze, Eric E and Seth, Punit P
Nucleic Acids Research, ISSN 0305-1048, 2014, Volume 42, Issue 13, pp. 8796 - 8807
Triantennary N-acetyl galactosamine (GalNAc, GN3), a high-affinity ligand for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), enhances the potency... 
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | NONHUMAN-PRIMATES | MESSENGER-RNA | LIVER-CELLS | FACTOR-XI | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | MEDIATED ENDOCYTOSIS | APOLIPOPROTEIN-B | HEPATIC ASIALOGLYCOPROTEIN RECEPTOR | Humans | Liver - metabolism | Mice, Inbred C57BL | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - metabolism | Galactosamine - chemistry | Male | Mice, Transgenic | Apolipoprotein C-III - genetics | Hepatocytes - metabolism | alpha 1-Antitrypsin | Galactosamine - analogs & derivatives | Prealbumin - antagonists & inhibitors | Factor XI - antagonists & inhibitors | Animals | Asialoglycoprotein Receptor - metabolism | Glycolipids - chemistry | Oligonucleotides, Antisense - administration & dosage | Mice | Mice, Inbred BALB C | Synthetic Biology and Chemistry
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5. Full Text cis-Antisense RNA, Another Level of Gene Regulation in Bacteria
by Jens Georg and Wolfgang R. Hess
Microbiology and Molecular Biology Reviews, ISSN 1092-2172, 06/2011, Volume 75, Issue 2, pp. 286 - 300
Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
VIBRIO-ANGUILLARUM | SITE ACCESSIBILITY | ESCHERICHIA-COLI | OOP RNA | TRANSCRIPTIONAL INTERFERENCE | MICROBIOLOGY | PROTEIN GENE | SMALL NONCODING RNAS | SOLUBLE-RNAS | EXPRESSION | IRON TRANSPORT GENES | Bacteria - metabolism | RNA, Antisense - chemistry | RNA, Antisense - metabolism | Gene Expression Profiling | Gene Expression Regulation, Bacterial | Bacteria - genetics | RNA, Antisense - genetics | Antisense RNA | Bacteria | Genetic aspects | Research | Gene expression | Genetic regulation | Reviews
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6. Full Text Antisense oligonucleotides in therapy for neurodegenerative disorders
by Evers, Melvin M and Toonen, Lodewijk J.A and van Roon-Mom, Willeke M.C
Advanced Drug Delivery Reviews, ISSN 0169-409X, 06/2015, Volume 87, pp. 90 - 103
Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to RNA and thereby alter or reduce expression of the target RNA.... 
Genetic therapies | Allele-specific reduction | Splicing modulation | Blood brain barrier | Translational blockage | Neurodegenerative disorders | RNase H-mediated degradation | IN-VIVO CORRECTION | SURVIVAL MOTOR-NEURON | CELL-PENETRATING PEPTIDES | AMYLOID PRECURSOR PROTEIN | BLOOD-BRAIN-BARRIER | PEPTIDE NUCLEIC-ACID | SPINAL MUSCULAR-ATROPHY | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | STEROID-RECEPTOR COACTIVATOR-1 | SINGLE-NUCLEOTIDE POLYMORPHISMS | Gene Targeting | Alternative Splicing - genetics | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Neurodegenerative Diseases - genetics | Structure-Activity Relationship | Neurodegenerative Diseases - drug therapy | Blood-Brain Barrier - metabolism | Drug Delivery Systems | Alternative Splicing - drug effects | Animals | Oligonucleotides, Antisense - therapeutic use | Oligonucleotides, Antisense - administration & dosage | Drugs | Care and treatment | Nervous system diseases | Multiple sclerosis | Drug delivery systems | Peptides | RNA | Glycogen | Neurons | Creutzfeldt-Jakob disease | Amyloid beta-protein | Development and progression | Superoxide | Ribonuclease | Glutamate | Vehicles | Prevention | Synthesis | Huntington's chorea | Prions | Single nucleotide polymorphisms
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7. Full Text Improved targeting of miRNA with antisense oligonucleotides
by Davis, Scott and Lollo, Bridget and Freier, Susan and Esau, Christine
Nucleic Acids Research, ISSN 0305-1048, 2006, Volume 34, Issue 8, pp. 2294 - 2304
MicroRNAs (miRNAs) are a class of 20-24 nt noncoding RNAs that regulate target mRNAs post-transcriptionally by binding with imperfect complementarity in the... 
GENE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | VALIDATION | ANTITUMOR-ACTIVITY | EXPRESSION | SMALL INTERFERING RNAS | FUNCTIONAL GENOMICS | NUCLEASE RESISTANCE | MICRORNA | MicroRNAs - antagonists & inhibitors | Carbohydrates - chemistry | RNA Interference | MicroRNAs - analysis | Humans | Oligonucleotides, Antisense - chemistry | Phosphates - chemistry | Base Pair Mismatch | HeLa Cells | Kinetics | MicroRNAs - chemistry | Genes, Reporter
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8. Full Text R-Loop Stabilization Represses Antisense Transcription at the Arabidopsis FLC Locus
by Qianwen Sun and Tibor Csorba and Konstantina Skourti-Stathaki and Nicholas J. Proudfoot and Caroline Dean
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 619 - 621
Roles for long noncoding RNAs (lncRNAs) in gene expression are emerging, but regulation of the lncRNA itself is poorly understood. We have identified a... 
Polymerase chain reaction | RNA | DNA | REPORTS | Genetic loci | Terminator regions | Gene expression regulation | Single stranded DNA | Promoter regions | Gene expression | Hybridity | RNA-BINDING | CHROMATIN | NATURAL VARIATION | MULTIDISCIPLINARY SCIENCES | REGIONS | VERNALIZATION | SWITCH | TERMINATION | HYBRIDS | Chromatin - metabolism | Homeodomain Proteins - metabolism | Molecular Sequence Data | RNA, Plant - metabolism | Arabidopsis Proteins - metabolism | DNA, Plant - chemistry | RNA, Antisense - chemistry | RNA, Plant - chemistry | Transcription Termination, Genetic | Gene Expression Regulation, Plant | Transcription, Genetic | Nucleic Acid Conformation | Amino Acid Sequence | Promoter Regions, Genetic | Arabidopsis Proteins - genetics | RNA, Long Noncoding - chemistry | DNA, Single-Stranded - metabolism | MADS Domain Proteins - genetics | RNA, Long Noncoding - genetics | RNA, Plant - genetics | DNA, Plant - metabolism | Homeodomain Proteins - chemistry | DNA, Single-Stranded - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | MADS Domain Proteins - metabolism | Arabidopsis Proteins - chemistry | RNA, Antisense - metabolism | Protein Binding | RNA, Long Noncoding - metabolism | RNA, Antisense - genetics | Arabidopsis thaliana | Plants, Flowering of | Physiological aspects | Genetic aspects | Genetic transcription | Research | Gene loci | Insects | Ribonucleic acid--RNA | Proteins | Regulators | Control | Stabilization | Integrals | Flowering | Genetics | Sun
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9. Full Text Bacterial antisense RNAs: How many are there, and what are they doing?
by Thomason, Maureen Kiley and Storz, Gisela
Annual Review of Genetics, ISSN 0066-4197, 12/2010, Volume 44, Issue 1, pp. 167 - 188
Antisense RNAs encoded on the DNA strand opposite another gene have the potential to form extensive base-pairing interactions with the corresponding sense RNA.... 
transcription interference | gene regulation | Small RNA | mRNA stability | HOK MESSENGER-RNA | CLOSTRIDIUM-ACETOBUTYLICUM FERMENTATIONS | ESCHERICHIA-COLI | DOWN-REGULATION | small RNA | COLE1 PLASMID REPLICATION | ANABAENA-SP PCC-7120 | NONCODING RNAS | TARGET RNA | GENETICS & HEREDITY | GENE-EXPRESSION | STAPHYLOCOCCUS-AUREUS | Gene Expression Regulation, Bacterial | Bacteria - genetics | RNA, Bacterial - metabolism | RNA, Antisense - chemistry | RNA, Antisense - metabolism | RNA, Bacterial - chemistry | Analysis | Oligonucleotides | Antisense RNA | Research | Chemical properties | Genetic transcription | Gene expression | Structure
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10. Full Text Short antisense oligonucleotides with novel 2′-4′ conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals
by Seth, Punit P and Siwkowski, Andrew and Allerson, Charles R and Vasquez, Guillermo and Lee, Sam and Prakash, Thazha P and Wancewicz, Edward V and Witchell, Donna and Swayze, Eric E
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2009, Volume 52, Issue 1, pp. 10 - 13
The potency of second generation antisense oligonucleotides (ASOs) in anitnals was increased 3- to 5 -fold (ED50 approximate to 2-5 mg/kg) without producing... 
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | CHEMISTRY, MEDICINAL | INHIBITION | CHOLESTEROL | GENE-EXPRESSION | MICE | APOLIPOPROTEIN-B | Gene Expression Regulation, Enzymologic - drug effects | PTEN Phosphohydrolase - genetics | Nucleosides - chemistry | Liver - enzymology | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - toxicity | Male | Animals | Liver - drug effects | Gene Expression Regulation, Enzymologic - genetics | Mice | Mice, Inbred BALB C | Molecular Structure | Nucleic Acid Conformation | Toxicity Tests | RNA, Messenger - drug effects | Index Medicus
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11. Full Text Antisense transcripts are targets for activating small RNAs
by Younger, Scott T and Schwartz, Jacob C and Nguyen, Ngoc-Bich and Janowski, Bethany A and Corey, David R and Hardy, Daniel B and Monia, Brett P
Nature Structural & Molecular Biology, ISSN 1545-9993, 08/2008, Volume 15, Issue 8, pp. 842 - 848
Agents that activate expression of specific genes to probe cellular pathways or alleviate disease would go beyond existing approaches for controlling gene... 
CELLS | METHYLATION | PROTEIN | BIOPHYSICS | REPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | INTERFERENCE | MIRNAS | CHROMOSOMAL DNA | ARGONAUTE2 | CELL BIOLOGY | Humans | Gene Silencing | Heterogeneous-Nuclear Ribonucleoprotein K - chemistry | RNA Polymerase II - metabolism | Genetic Techniques | RNA - chemistry | RNA, Untranslated - genetics | Receptors, Progesterone - metabolism | Biotin - chemistry | RNA, Small Interfering - chemistry | RNA, Antisense - chemistry | Polymerase Chain Reaction | Cell Line, Tumor | Models, Genetic | DNA, Complementary - metabolism | RNA - metabolism | RNA, Small Interfering - metabolism | Physiological aspects | Antisense nucleic acids | Promoters (Genetics) | Research | Gene expression | Signal transduction | Cellular biology | Ribonucleic acid--RNA | Molecular biology
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