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1. Full Text Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
by Shen, Xiulong and Corey, David R
Nucleic acids research, ISSN 0305-1048, 02/2018, Volume 46, Issue 4, pp. 1584 - 1600
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Biosynthesis | MicroRNAs - antagonists & inhibitors | Alternative Splicing | RNA Interference | Humans | Oligonucleotides, Antisense - therapeutic use | Oligonucleotides, Antisense - chemistry | RNA, Double-Stranded - therapeutic use | Clinical Trials as Topic | Proteins - antagonists & inhibitors | RNA, Double-Stranded - chemistry | Index Medicus | Survey and Summary
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2. Molecular Mechanisms of Antisense Oligonucleotides
by Crooke, Stanley T
Nucleic acid therapeutics, ISSN 2159-3337, 04/2017, Volume 27, Issue 2, pp. 70 - 77
RNase H | RNA | mechanisms | DNA | antisense | oligonucleotide | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Nucleic Acid Hybridization | Membrane Glycoproteins - metabolism | Humans | RNA, Messenger - genetics | Gene Expression Regulation | Oligonucleotides, Antisense - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Membrane Glycoproteins - genetics | Receptors, Complement - metabolism | Oligonucleotides, Antisense - genetics | Biological Transport | RNA, Messenger - antagonists & inhibitors | Receptors, Complement - genetics | Cell Membrane - metabolism | Eukaryotic Cells - cytology | Kinetics | Ribonuclease H - genetics | Ribonuclease H - metabolism | Ribonucleic acid--RNA | Biochemistry | Pharmaceutical sciences | Index Medicus
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3. Full Text Natural antisense transcripts
by Khorkova, Olga and Myers, Amanda J and Hsiao, Jane and Wahlestedt, Claes
Human molecular genetics, ISSN 0964-6906, 2014, Volume 23, Issue 1, pp. R54 - R63
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Gene Targeting | Gene Expression | Humans | Transcription, Genetic | RNA, Antisense - therapeutic use | Genome | RNA, Untranslated - genetics | RNA, Antisense - genetics | Index Medicus
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4. Full Text Synthesis and antisense properties of 2β-f-arabinouridine modified oligonucleotides with 4-C-OMe substituent
by He, Xiao-Yang and Wang, Jing and Lu, Dan-Dan and Wang, Sheng-Qi
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2018, Volume 23, Issue 9, p. 2374
Chemical modification | Arabinonucleotide | Fluorine | Pseudohydrogen bond | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Nucleic Acid Denaturation | Oligonucleotides, Antisense - pharmacology | Phosphoric Diester Hydrolases - metabolism | Oligonucleotides, Antisense - chemical synthesis | Enzyme Stability | Oligonucleotides, Antisense - chemistry | Snake Venoms - enzymology | Uridine - chemical synthesis | Uridine - chemistry | Uridine - pharmacology | RNA modification | Automation | Oligonucleotides | Antisense oligonucleotides | Thymidine | Selectivity | Hybridization | Ribonucleic acid--RNA | Circular dichroism | Complement component C4 | Dichroism | Destabilization | Deoxyribonucleic acid--DNA | Sugar | Conformation | Index Medicus | pseudohydrogen bond | chemical modification | arabinonucleotide | fluorine
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5. Full Text Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
by Seth, Punit P and Siwkowski, Andrew and Allerson, Charles R and Vasquez, Guillermo and Lee, Sam and Prakash, Thazha P and Wancewicz, Edward V and Witchell, Donna and Swayze, Eric E
Journal of medicinal chemistry, ISSN 0022-2623, 01/2009, Volume 52, Issue 1, pp. 10 - 13
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Pharmacology. Drug treatments | Gene Expression Regulation, Enzymologic - drug effects | PTEN Phosphohydrolase - genetics | Nucleosides - chemistry | Liver - enzymology | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - toxicity | Male | Animals | Liver - drug effects | Gene Expression Regulation, Enzymologic - genetics | Mice | Mice, Inbred BALB C | Molecular Structure | Nucleic Acid Conformation | Toxicity Tests | RNA, Messenger - drug effects | Index Medicus
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6. Full Text Splice-switching antisense oligonucleotides as therapeutic drugs
by Havens, Mallory A and Hastings, Michelle L
Nucleic acids research, ISSN 0305-1048, 08/2016, Volume 44, Issue 14, pp. 6549 - 6563
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Genetic Therapy | Gene Expression | Animals | Humans | Oligonucleotides, Antisense - therapeutic use | RNA Splicing - genetics | Clinical Trials as Topic | Index Medicus | Survey and Summary
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7. Full Text miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
by Hansen, Thomas B and Wiklund, Erik D and Bramsen, Jesper B and Villadsen, Sune B and Statham, Aaron L and Clark, Susan J and Kjems, Jørgen
The EMBO journal, ISSN 0261-4189, 11/2011, Volume 30, Issue 21, pp. 4414 - 4422
nuclear microRNA | miR‐671 | natural antisense transcript | circular RNA | CDR1 | miR-671 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA Interference - drug effects | Autoantigens - metabolism | Humans | Molecular Sequence Data | RNA Cleavage - physiology | Autoantigens - genetics | MicroRNAs - pharmacology | RNA Splicing - physiology | Base Sequence | RNA Splicing - genetics | RNA, Antisense - chemistry | HEK293 Cells | Argonaute Proteins - physiology | Nucleic Acid Conformation | RNA - metabolism | Argonaute Proteins - metabolism | Gene Expression Regulation - genetics | RNA - drug effects | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | RNA Cleavage - drug effects | RNA Cleavage - genetics | Models, Biological | RNA, Antisense - metabolism | MicroRNAs - physiology | Proteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Molecular biology | Index Medicus
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8. Antisense drug discovery and development
by Yamamoto, Tsuyoshi and Nakatani, Moeka and Narukawa, Keisuke and Obika, Satoshi
Future medicinal chemistry, ISSN 1756-8919, 03/2011, Volume 3, Issue 3, pp. 339 - 365
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Bridged-Ring Compounds - therapeutic use | Chemistry, Pharmaceutical - methods | Thionucleotides - therapeutic use | Antiviral Agents - therapeutic use | Muscular Dystrophy, Duchenne - drug therapy | Humans | Oligonucleotides, Antisense - chemistry | Drug Discovery - methods | Oligonucleotides, Antisense - adverse effects | RNA - chemistry | Morpholines - chemistry | Bridged-Ring Compounds - chemistry | Dystrophin - genetics | Oligonucleotides, Antisense - therapeutic use | Morpholinos | Phosphorothioate Oligonucleotides - chemistry | Phosphorothioate Oligonucleotides - therapeutic use | DNA, Antisense - chemistry | Morpholines - therapeutic use
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