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FEBS letters, ISSN 0014-5793, 07/2015, Volume 589, Issue 16, pp. 2080 - 2086
•Mutations in YsxC conserved positively charged patch do not affect 50S YsxC binding.•YsxC-R31A and YsxC-R116A strongly bind both 30S and 50S ribosomal... 
Ribosome binding | Bacillus subtilis | GTPase | YsxC | DOMAIN | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | ERA | GROWTH | SUBUNIT | Ribosome Subunits, Large, Bacterial - metabolism | Molecular Conformation | Bacterial Proteins - chemistry | GTP Phosphohydrolases - chemistry | Protein Stability | Binding Sites | Peptide Fragments - genetics | RNA, Bacterial - metabolism | RNA, Ribosomal, 16S - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Ribosome Subunits, Small, Bacterial - metabolism | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Bacillus subtilis - enzymology | Hot Temperature | Molecular Dynamics Simulation | Arginine - chemistry | RNA, Ribosomal, 23S - chemistry | Peptide Fragments - chemistry | RNA, Ribosomal, 16S - chemistry | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Ribosome Subunits, Large, Bacterial - chemistry | Mutant Proteins - chemistry | RNA, Bacterial - chemistry | Bacterial Proteins - metabolism | Ligands | Ribosome Subunits, Small, Bacterial - chemistry | Histidine - chemistry | Lysine - chemistry | RNA, Ribosomal, 23S - metabolism | Bacillus subtilis - metabolism | Amino Acid Substitution | Peptide Fragments | GTP Phosphohydrolases | Recombinant Proteins | Life Sciences | Histidine | Arginine | Ribosome Subunits, Small, Bacterial | Biomolecules | RNA, Bacterial | RNA, Ribosomal, 16S | Biochemistry, Molecular Biology | Bacterial Proteins | Mutant Proteins | Lysine | RNA, Ribosomal, 23S | Ribosome Subunits, Large, Bacterial
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 66, Issue 2, pp. 221 - 233.e4
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 02/2010, Volume 76, Issue 3, pp. 910 - 921
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
PUTISOLVIN-II | GENE-CLUSTER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOSYNTHESIS | SWARMING MOTILITY | FUNCTIONAL-ANALYSIS | HOST-DEFENSE | MICROBIOLOGY | DICTYOSTELIUM-DISCOIDEUM | CHANNEL-FORMING ACTIVITIES | SYRINGAE PV. SYRINGAE | PEPTIDE | Pest Control, Biological | Virulence Factors - genetics | RNA, Untranslated - metabolism | RNA, Untranslated - genetics | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Lipopeptides - metabolism | Virulence - genetics | RNA, Bacterial - genetics | Lipopeptides - chemistry | Pseudomonas - genetics | RNA, Bacterial - metabolism | Repressor Proteins - metabolism | Drosophila - genetics | Hemolytic Agents - chemistry | Amino Acid Sequence | Endopeptidases - metabolism | Genes, Bacterial | Genome, Bacterial | Soil Microbiology | Bacterial Proteins - genetics | Pseudomonas - pathogenicity | Repressor Proteins - genetics | Endopeptidase Clp - genetics | Lipopeptides - biosynthesis | Endopeptidase Clp - metabolism | Hemolytic Agents - metabolism | Peptides, Cyclic - biosynthesis | Animals | Endopeptidases - genetics | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Drosophila - metabolism | Gene Expression Regulation, Bacterial | Pseudomonas - metabolism | Control | Peptides | Drosophila | Analysis | Physiological aspects | Genetic aspects | Chemical properties | Virulence (Microbiology) | Structure | Pseudomonas | Hemolysis and hemolysins | Amino acids | RNA, Untranslated | Repressor Proteins | Virulence | Endopeptidase Clp | Biochemistry, Molecular Biology | Virulence Factors | Bacterial Proteins | Peptides, Cyclic | Life Sciences | Microbiology and Parasitology | Hemolytic Agents | RNA, Bacterial | Lipopeptides | Endopeptidases | Invertebrate Microbiology
Journal Article
Journal Article
Nucleic acids research, ISSN 0305-1048, 01/2016, Volume 44, Issue 5, pp. 2429 - 2438
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 65, Issue 2, pp. 310 - 322
C2c1 is a type V-B CRISPR-Cas system dual-RNA-guided DNA endonuclease. Here, we report the crystal structure of Alicyclobacillus acidoterrestris C2c1 in... 
crystal structure | CRISPR-Cas system | C2c1 | genome-editing | DNA endonuclease | CRISPR-CAS SYSTEMS | ADAPTIVE IMMUNITY | ENDONUCLEASE | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | TARGET DNA | CLASSIFICATION | RESOLVASE | PROKARYOTES | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Nucleic Acid Heteroduplexes - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | DNA Breaks, Double-Stranded | Nucleic Acid Heteroduplexes - metabolism | Alicyclobacillus - enzymology | Alicyclobacillus - genetics | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | Endodeoxyribonucleases - metabolism | RNA, Bacterial - genetics | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | RNA, Bacterial - metabolism | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Endodeoxyribonucleases - chemistry | Nucleic Acid Heteroduplexes - chemistry | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Protein Binding | Bacterial Proteins - metabolism | Nucleases | RNA | Analysis | Genomics | DNA | Crystals | Structure
Journal Article
Annual review of genetics, ISSN 0066-4197, 12/2011, Volume 45, Issue 1, pp. 273 - 297
Bacteria and archaea have evolved defense and regulatory mechanisms to cope with various environmental stressors, including virus attack. This arsenal has been... 
RNAi | immunity | interference | bacteriophage | coevolution | Bacteriophage | Coevolution | Immunity | Interference | MYCOBACTERIUM-TUBERCULOSIS | ESCHERICHIA-COLI | PROVIDES ACQUIRED-RESISTANCE | REPEATS CRISPRS | IMMUNE-SYSTEM | GENOME SEQUENCE | ANTIVIRAL DEFENSE | STRUCTURAL BASIS | YERSINIA-PESTIS | GENETICS & HEREDITY | HORIZONTAL GENE-TRANSFER | RNA, Archaeal - immunology | Bacteria - chemistry | RNA, Archaeal - chemistry | Bacterial Proteins - chemistry | Archaea - chemistry | Virus Diseases - virology | Genetic Loci | Archaea - virology | Bacteria - immunology | RNA Interference | RNA, Small Untranslated - chemistry | Bacteriophages - genetics | RNA, Bacterial - genetics | RNA, Small Untranslated - genetics | Transcription, Genetic | Archaea - immunology | Bacterial Proteins - immunology | RNA, Archaeal - genetics | Virus Diseases - genetics | Bacteria - virology | Adaptive Immunity | Virus Diseases - immunology | RNA Processing, Post-Transcriptional | Plasmids - immunology | RNA, Small Untranslated - immunology | Bacterial Proteins - genetics | Computational Biology | Gene Expression Regulation, Archaeal | Endodeoxyribonucleases - chemistry | Bacteria - genetics | Bacteriophages - immunology | Endodeoxyribonucleases - genetics | Escherichia coli Proteins | RNA, Bacterial - chemistry | RNA, Bacterial - immunology | Archaea - genetics | CRISPR-Associated Proteins | Gene Expression Regulation, Bacterial | Evolution, Molecular | RNA | Physiological aspects | Bacteria | Genetic aspects | Research | Genetic regulation | Archaeabacteria
Journal Article