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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2001, Volume 98, Issue 17, pp. 9742 - 9747
Short interfering RNAs (siRNAs) are double-stranded RNAs of ≈21-25 nucleotides that have been shown to function as key intermediaries in triggering... 
Biological Sciences | Double stranded RNA | Transfection | Delta cells | RNA | Somatic cells | Cell lines | Small interfering RNA | HeLa cells | Nucleotides | Gene expression | ZEBRAFISH | MESSENGER-RNA | GERM-LINE | MULTIDISCIPLINARY SCIENCES | DROSOPHILA CELLS | POLYMERASE | DEPENDENT PROTEIN-KINASE | DEGRADATION | C-ELEGANS | INTERFERENCE | TRANSGENE | Mammals - genetics | Green Fluorescent Proteins | Phosphorylation | Gene Silencing - drug effects | Species Specificity | Vertebrates - genetics | Humans | HeLa Cells - metabolism | Chloramphenicol O-Acetyltransferase - genetics | RNA, Antisense - pharmacology | Luminescent Proteins - biosynthesis | Muscle Proteins - biosynthesis | Cell Death | RNA, Helminth - physiology | Genes, Reporter | Calmodulin-Binding Proteins - genetics | Recombinant Fusion Proteins - biosynthesis | Caenorhabditis elegans Proteins | Cells, Cultured - drug effects | Caenorhabditis elegans - metabolism | Endoribonucleases - metabolism | Caenorhabditis elegans - genetics | RNA, Antisense - chemical synthesis | RNA, Double-Stranded - physiology | Helminth Proteins - biosynthesis | Invertebrates - genetics | Helminth Proteins - genetics | HeLa Cells - drug effects | Muscle Proteins - genetics | Animals | Calmodulin-Binding Proteins - biosynthesis | Ribonuclease III | RNA, Double-Stranded - pharmacology | Luminescent Proteins - genetics | Cells, Cultured - metabolism | Mice | Chloramphenicol O-Acetyltransferase - biosynthesis | Gene Silencing - physiology | Physiological aspects | Caenorhabditis elegans | Genetic aspects | Invertebrates | siRNAs
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2003, Volume 4, Issue 12, pp. 1223 - 1229
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2005, Volume 348, Issue 5, pp. 1079 - 1090
The potential induction of inflammatory cytokines and interferon responses by small-interfering RNAs (siRNAs) represents a major obstacle for their use as... 
Toll-like receptors | RNA interference | inflammatory cytokines | innate immunity | siRNAs | Innate immunity | Inflammatory cytokines | IMMUNE-RESPONSE | ACTIVATION | toll-like receptors | DENDRITIC CELLS | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT MICE | TOLL-LIKE RECEPTOR-3 | TUMOR-NECROSIS-FACTOR | DNA | GENE-EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Leukocytes, Mononuclear - metabolism | RNA, Small Interfering - genetics | Endosomes - physiology | Gene Expression - drug effects | Gene Expression - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Toll-Like Receptor 8 | Toll-Like Receptors | Membrane Glycoproteins - physiology | Interferon-alpha - genetics | Dendritic Cells - drug effects | Receptors, Cell Surface - physiology | Cytokines - genetics | Interleukin-6 - metabolism | Dendritic Cells - metabolism | RNA, Double-Stranded - analysis | Interferon-alpha - metabolism | Leukocytes, Mononuclear - drug effects | Interleukin-6 - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | RNA, Small Interfering - analysis | Membrane Glycoproteins - genetics | NF-kappa B - genetics | RNA, Double-Stranded - genetics | RNA, Double-Stranded - pharmacology | Endosomes - chemistry | Cytokines - biosynthesis | Receptors, Cell Surface - genetics | Dendritic cells | RNA | Biological response modifiers | Gene expression | Interferon alpha
Journal Article