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Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 220 - 230
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 4, pp. 608 - 621.e6
Transcription is a source of genetic instability that can notably result from the formation of genotoxic DNA:RNA hybrids, or R-loops, between the nascent mRNA... 
genetic instability | intron | recombination | mRNA splicing | transcription | mRNP | R-loops | messenger ribonucleoparticle | ELONGATION IMPAIRMENT | YEAST | MESSENGER-RNA | CANDIDA-GLABRATA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOBAL ANALYSIS | R-LOOP FORMATION | SACCHAROMYCES-CEREVISIAE | EXPRESSION | SCHIZOSACCHAROMYCES-POMBE | REVEALS | CELL BIOLOGY | Genomic Instability | Nucleic Acid Heteroduplexes - genetics | DNA, Fungal - genetics | Spliceosomes - genetics | Saccharomyces cerevisiae - genetics | Humans | Cryptococcus neoformans - genetics | Databases, Genetic | DNA, Fungal - chemistry | Structure-Activity Relationship | Nucleic Acid Heteroduplexes - metabolism | Saccharomyces cerevisiae - metabolism | Schizosaccharomyces - genetics | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins - genetics | Transcription, Genetic | RNA, Fungal - genetics | Nucleic Acid Conformation | Gene Expression Regulation, Fungal | Cell Line | Introns | RNA, Fungal - chemistry | Computational Biology | Genotype | Ribonucleoproteins - metabolism | Fungal Proteins - genetics | Candida glabrata - metabolism | Cryptococcus neoformans - metabolism | Nucleic Acid Heteroduplexes - chemistry | RNA, Fungal - metabolism | Schizosaccharomyces - metabolism | Phenotype | DNA, Fungal - metabolism | DNA Damage | Candida glabrata - genetics | Fungal Proteins - metabolism | RNA | Analysis | Genes | Genomics | Genetic research | Genetic aspects | Genetic transcription | Anopheles | Messenger RNA | Index Medicus | Cryptococcus neoformans | Life Sciences | RNA, Fungal | Spliceosomes | Schizosaccharomyces | Biochemistry, Molecular Biology | Ribonucleoproteins | Fungal Proteins | Candida glabrata | DNA, Fungal | Nucleic Acid Heteroduplexes | Molecular biology | Saccharomyces cerevisiae
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7389, pp. 295 - 301
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 537, Issue 7619, pp. 197 - 201
Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat-intron intermediate. Here we present the 3.8 angstrom... 
U4/U6.U5 TRI-SNRNP | IN-VITRO | ELECTRON CRYOMICROSCOPY | ACTIVE-SITE | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | PRE-MESSENGER-RNA | CATALYTIC ACTIVATION | RNA Precursors - chemistry | RNA Helicases - metabolism | Spliceosomes - chemistry | RNA, Fungal - ultrastructure | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA Precursors - metabolism | RNA, Fungal - genetics | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Introns - genetics | RNA Splice Sites - genetics | RNA, Fungal - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Exons - genetics | Magnesium - metabolism | Nuclear Proteins - metabolism | Spliceosomes - ultrastructure | Esterification | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Base Pairing | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Structure | Brewer's yeast | Methods | RNA splicing | Proteins | Enzymes | Molecular structure | Microscopy | Catalysis | Ribonucleic acid--RNA | Binding sites | Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 544 - 550
RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model... 
Genetic transposition | Double stranded RNA | Messenger RNA | Transposons | RNA | Genomics | Small interfering RNA | Genetic loci | Research Articles | Open reading frames | Saccharomycetales | ELEMENTS | EVOLUTION | INITIATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | RESOLUTION | PROTEINS | SACCHAROMYCES-CEREVISIAE | GENOME | RIBONUCLEASE | SCHIZOSACCHAROMYCES-POMBE | RNA, Small Interfering - genetics | Saccharomyces cerevisiae - genetics | Open Reading Frames | Gene Expression Profiling | Genetic Loci | RNA, Messenger - metabolism | Saccharomyces - genetics | Saccharomyces cerevisiae - metabolism | RNA Interference | Saccharomyces - metabolism | Genes, Fungal | Transcription, Genetic | RNA, Double-Stranded - metabolism | RNA, Fungal - genetics | Transformation, Genetic | Ribonuclease III - genetics | Ribonuclease III - metabolism | Retroelements | RNA, Messenger - genetics | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | RNA, Fungal - metabolism | Saccharomycetales - genetics | Sequence Analysis, RNA | RNA, Double-Stranded - genetics | Saccharomyces cerevisiae Proteins - metabolism | Repetitive Sequences, Nucleic Acid | Mutation | Saccharomycetales - metabolism | Fungal Proteins - metabolism | RNA, Small Interfering - metabolism | Physiological aspects | Brewer's yeast | Genetic aspects | Proteins | Signal transduction | Yeast | Cellular biology | Ribonucleic acid--RNA | Gene expression | Dicer protein | Index Medicus
Journal Article