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Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 221 - 233.e4
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
Journal Article
Journal Article