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Molecular therapy, ISSN 1525-0016, 2017, Volume 25, Issue 5, pp. 1168 - 1186
...) vector to deliver multiplex single-guide RNAs (sgRNAs) plus Staphylococcus aureus Cas9 (saCas9... 
genome editing | humanized BLT mice | animal models | viral latency | HIV | AAV | Tg26 mice | gene therapy | Cas9 | gRNA | EFFICIENT DELIVERY | MEDICINE, RESEARCH & EXPERIMENTAL | GENE EDITING TECHNOLOGIES | PACKAGING CAPACITY | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRAL VECTORS | STAPHYLOCOCCUS-AUREUS CAS9 | CRISPR-CAS9 NUCLEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR/CAS9 SYSTEM | GENETICS & HEREDITY | MODULATES PROLIFERATION | NEURAL PRECURSOR CELLS | Oligonucleotides - genetics | Dependovirus - genetics | Endonucleases - genetics | Staphylococcus aureus - enzymology | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | HIV Long Terminal Repeat | pol Gene Products, Human Immunodeficiency Virus - metabolism | Endonucleases - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | HIV Infections - pathology | Proviruses - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | gag Gene Products, Human Immunodeficiency Virus - genetics | pol Gene Products, Human Immunodeficiency Virus - genetics | Disease Models, Animal | Genome, Viral | HIV-1 - metabolism | Dependovirus - metabolism | Genetic Vectors - chemistry | HIV Infections - virology | Bacterial Proteins - genetics | Genetic Vectors - metabolism | Mice, Transgenic | HIV-1 - genetics | Proviruses - metabolism | Staphylococcus aureus - chemistry | Oligonucleotides - metabolism | Animals | CRISPR-Cas Systems | HIV Infections - therapy | Bacterial Proteins - metabolism | Gene Editing - methods | Mice | Genetic Therapy - methods | Neuroimaging | Animal models | Bioluminescence | Intravenous administration | Genes | Liver | Clinical trials | Chronic infection | Infections | Genomes | Thymus | Acquired immune deficiency syndrome--AIDS | Efficiency | Transgenic animals | Human immunodeficiency virus--HIV | Bone marrow | Colon | Deoxyribonucleic acid--DNA | Spleen | CRISPR | Gene transfer | Advisors | Transgenic mice | Ribonucleic acid--RNA | Progenitor cells | Polymerase chain reaction | Studies | Genotyping | Neural stem cells | Original
Journal Article
by Myers, Richard M and Stamatoyannopoulos, John and Snyder, Michael and Dunham, Ian and Hardison, Ross C and Bernstein, Bradley E and Gingeras, Thomas R and Kent, W. James and Birney, Ewan and Wold, Barbara and Crawford, Gregory E and Epstein, Charles B and Shoresh, Noam and Ernst, Jason and Mikkelsen, Tarjei S and Kheradpour, Pouya and Zhang, Xiaolan and Wang, Li and Issner, Robbyn and Coyne, Michael J and Durham, Timothy and Ku, Manching and Truong, Thanh and Ward, Lucas D and Altshuler, Robert C and Lin, Michael F and Kellis, Manolis and Davis, Carrie A and Kapranov, Philipp and Dobin, Alexander and Zaleski, Christopher and Schlesinger, Felix and Batut, Philippe and Chakrabortty, Sudipto and Jha, Sonali and Lin, Wei and Drenkow, Jorg and Wang, Huaien and Bell, Kim and Bell, Ian and Gao, Hui and Dumais, Erica and Dumais, Jacqueline and Antonarakis, Stylianos E and Ucla, Catherine and Borel, Christelle and Guigo, Roderic and Djebali, Sarah and Lagarde, Julien and Kingswood, Colin and Ribeca, Paolo and Sammeth, Micha and Alioto, Tyler and Merkel, Angelika and Tilgner, Hagen and Carninci, Piero and Hayashizaki, Yoshihide and Lassmann, Timo and Takahashi, Hazuki and Abdelhamid, Rehab F and Hannon, Gregory and Fejes, Katalin-Toth and Preall, Jonathan and Gordon, Assaf and Sotirova, Vihra and Reymond, Alexandre and Howald, Cedric and Graison, Emilie Aït Yahya and Chrast, Jacqueline and Ruan, Yijun and Ruan, Xiaoan and Shahab, Atif and Poh, Wan Ting and Wei, Chia-Lin and Furey, Terrence S and Boyle, Alan P and Sheffield, Nathan C and Song, Lingyun and Shibata, Yoichiro and Vales, Teresa and Winter, Deborah and Zhang, Zhancheng and London, Darin and Wang, Tianyuan and Keefe, Damian and Iyer, Vishwanath R and Lee, Bum-Kyu and McDaniell, Ryan M and Liu, Zheng and Battenhouse, Anna and Bhinge, Akshay A and Lieb, Jason D and Grasfeder, Linda L and Showers, Kimberly A and Giresi, Paul G and Kim, Seul K. C and Shestak, Christopher and Pauli, Florencia and Reddy, Timothy E and Gertz, Jason and ... and The ENCODE Project Consortium and ENCODE Project Consortium
PLoS biology, ISSN 1545-7885, 2011, Volume 9, Issue 4, p. e1001046
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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5891, pp. 960 - 964
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 66, Issue 2, pp. 221 - 233.e4
...: endoribonuclease activity for processing its own guide RNAs and RNA-guided DNase activity for target DNA cleavage... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
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