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eLife, ISSN 2050-084X, 2018, Volume 7
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the... 
endoribonuclease | cell biology | histone pre-mRNA 3' end processing | chromosomes | metallo β-lactamase | S-phase | human | gene expression | MBL domain containing protein 1 | COMPLEX | PROTEIN | METALLO-BETA-LACTAMASE | BIOLOGY | 3'-END MATURATION | POLYADENYLATION FACTOR CPSF-73 | CELL-CYCLE | CLEAVAGE | POLY(A) | FAMILY | REVEALS | Endoribonucleases - chemistry | Endoribonucleases - genetics | Humans | Histones - biosynthesis | Substrate Specificity | Crystallography, X-Ray | S Phase Cell Cycle Checkpoints | RNA, Messenger - biosynthesis | beta-Lactamases - genetics | Cloning, Molecular | Escherichia coli - metabolism | HEK293 Cells | Protein Interaction Domains and Motifs | beta-Lactamases - metabolism | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Mutagenesis, Site-Directed | Endoribonucleases - metabolism | Genetic Vectors - chemistry | RNA, Messenger - genetics | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | beta-Lactamases - chemistry | Sequence Alignment | Histones - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | HeLa Cells | Kinetics | Physiological aspects | Biosynthesis | Messenger RNA | Observations | CRISPR | Enzymes | Cloning | Cyclin-dependent kinases | mRNA | Kinases | Proteins | E coli | Polyadenylation | Cell cycle | Endonuclease | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Nature genetics, ISSN 1546-1718, 2015, Volume 47, Issue 12, pp. 1475 - 1481
.... We found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione... 
ACTIVATION | PROTEIN | GLUTAMINE | PATHWAY | GLUCOSE | GROWTH | GENETICS & HEREDITY | GENE-EXPRESSION | IMPAIR | CARCINOMA | KEAP1 MUTATIONS | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Cell Proliferation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Serine - biosynthesis | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Blotting, Western | Xenograft Model Antitumor Assays | Animals | NF-E2-Related Factor 2 - metabolism | Biomarkers, Tumor - genetics | Mice | Adenocarcinoma - mortality | Apoptosis | Transcription factors | Cell metabolism | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Properties | Health aspects | Medical research | Enzymes | Lung cancer | Biosynthesis | RNA polymerase | Metabolism | Gene expression | Experiments | Metabolites | Scientific imaging | Tumorigenesis | Labeling | Bioinformatics | Mass spectrometry
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 9/2006, Volume 103, Issue 39, pp. 14602 - 14607
...Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis Roberto C. Agı ´s-Balboa*, Graziano Pinna, Adrian Zhubi, Ekrem... 
Brain | Enzymes | Receptors | Messenger RNA | Neurons | Purkinje cells | Pyramidal cells | Neuroglia | Antibodies | Hippocampus | Glutamatergic neurons | 5α-reductase (type I) | GABAergic neurons | 3α-hydroxysteroid dehydrogenase | GABA(A) RECEPTOR FUNCTION | ALLOPREGNANOLONE SYNTHESIS | SOCIAL-ISOLATION | REELIN MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | STEROID 5-ALPHA-REDUCTASE | glutamatergic neurons | 3 alpha-hydroxysteroid dehydrogenase | NEUROACTIVE STEROIDS | 5 alpha-reductase (type I) | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | 3-ALPHA-HYDROXYSTEROID DIHYDRODIOL DEHYDROGENASE | Brain - enzymology | Male | Neurons - cytology | Cerebellum - enzymology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Corpus Striatum - cytology | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - genetics | Amygdala - enzymology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Hippocampus - enzymology | Corpus Striatum - enzymology | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Cerebral Cortex - enzymology | RNA, Messenger - genetics | Thalamus - enzymology | Rats | Amygdala - cytology | Hippocampus - cytology | Desoxycorticosterone - analogs & derivatives | Desoxycorticosterone - biosynthesis | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Pregnanolone - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - metabolism | Neurons - enzymology | Cerebellum - cytology | Thalamus - cytology | Mice | GABA | Research | Progesterone | Oxidoreductases | Structure | Steroids | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 42, pp. 17408 - 17413
...), is a potent inhibitor of TNF biosynthesis in human macrophages. This difference in response is not because of variation in Toll-like receptor 2-dependent activation of the signaling kinase MAPK p38... 
Untranslated regions | RNA stability | Cell culture techniques | Messenger RNA | MicroRNA | Mycobacterium tuberculosis | Infections | Biosynthesis | Physiological regulation | Macrophages | Innate immunity | Intracellular pathogen | Cell signaling | Lipoglycans | TRANSLOCATION | LOCALIZATION | CYTOKINES | MULTIDISCIPLINARY SCIENCES | P38 MAPK | lipoglycans | MESSENGER-RNA STABILITY | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | innate immunity | intracellular pathogen | cell signaling | INFECTION | BINDING | EXPRESSION | Promoter Regions, Genetic | Phosphorylation | Humans | Tumor Necrosis Factor-alpha - genetics | Mycobacterium tuberculosis - immunology | MicroRNAs - metabolism | MAP Kinase Kinase 2 - metabolism | Toll-Like Receptor 2 - metabolism | RNA Stability | Lipopolysaccharides - immunology | MAP Kinase Signaling System - immunology | Mycobacterium tuberculosis - pathogenicity | Macrophages - metabolism | Virulence - immunology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | MicroRNAs - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | In Vitro Techniques | Proto-Oncogene Proteins c-akt - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Macrophages - immunology | Macrophages - microbiology | Tumor necrosis factor | Physiological aspects | Genetic aspects | Research | Mitogen-activated protein kinases | Biological Sciences
Journal Article
Journal Article