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1. Full Text Analytic and Clinical Validation of a Prostate Cancer–Enhanced Messenger RNA Detection Assay in Whole Blood as a Prognostic Biomarker for Survival
by Danila, Daniel C and Anand, Aseem and Schultz, Nikolaus and Heller, Glenn and Wan, Mingliang and Sung, Clifford C and Dai, Charles and Khanin, Raya and Fleisher, Martin and Lilja, Hans and Scher, Howard I
European Urology, ISSN 0302-2838, 2013, Volume 65, Issue 6, pp. 1191 - 1197
Abstract Background Biomarkers based on detecting prostate cancer (PCa)-specific transcripts in blood are associated with inferior outcomes, but their... 
Urology | Prostate-specific markers | Biomarker | Circulating tumor cells | Prostate cancer | FOXA1 | CIRCULATING TUMOR-CELLS | UROLOGY & NEPHROLOGY | PERIPHERAL-BLOOD | MUTATIONS | CARCINOMA | ANTIGEN | Prostate-Specific Antigen - genetics | Prognosis | Prostatic Neoplasms, Castration-Resistant - blood | Humans | Middle Aged | Kallikreins - genetics | Male | Survival Rate | Hepatocyte Nuclear Factor 3-alpha - genetics | Tissue Kallikreins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Prostatic Neoplasms, Castration-Resistant - genetics | Prostatic Neoplasms, Castration-Resistant - pathology | Biomarkers, Tumor - blood | Neoplasm Metastasis | RNA, Messenger - blood | Neoplastic Cells, Circulating | Aged, 80 and over | Aged | Medical colleges | Messenger RNA
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2. Full Text MiRNA in plasma exosome is stable under different storage conditions
by Ge, Qinyu and Zhou, Youxia and Lu, Jiafeng and Bai, Yunfei and Xie, Xueying and Lu, Zuhong
Molecules, ISSN 1420-3049, 02/2014, Volume 19, Issue 2, pp. 1568 - 1575
Exosomes are small membrane-bound vesicles secreted by most cell types. Exosomes contain various functional proteins, mRNAs and microRNAs (miRNAs) that could... 
Storage condition | Exosome miRNA | Stability | CIRCULATING MICRORNAS | MECHANISM | RNA | exosome miRNA | CHEMISTRY, ORGANIC | storage condition | SERUM | stability | BLOOD | Exosomes - metabolism | RNA, Messenger - blood | Humans | RNA, Messenger - chemistry | MicroRNAs - blood | Biomarkers - blood | RNA - chemistry | RNA Stability
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3. Full Text Cell-free nucleic acids as biomarkers in cancer patients
by Hoon, Dave S. B and Pantel, Klaus and Schwarzenbach, Heidi
Nature Reviews Cancer, ISSN 1474-175X, 06/2011, Volume 11, Issue 6, pp. 426 - 437
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with... 
BREAST-CANCER | BLOOD-BASED MARKERS | FREE SERUM DNA | BARR-VIRUS DNA | CIRCULATING TUMOR-CELLS | ONCOLOGY | COLORECTAL-CANCER | CPG ISLAND HYPERMETHYLATION | PLASMA DNA | PROSTATE-CANCER | QUANTITATIVE-ANALYSIS | Biomarkers, Tumor - blood | DNA, Viral - blood | Neoplasms - blood | RNA, Messenger - blood | Neoplasms - genetics | Humans | MicroRNAs - blood | Mutation | Apoptosis | DNA - blood | Usage | Care and treatment | Cancer patients | Ras genes | Prognosis | Colorectal cancer | Development and progression | Genetic aspects | Research | Biological markers | Diseases
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4. Full Text Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first & second-line Abiraterone & Enzalutamide
by Antonarakis, Emmanuel S and Lu, Changxue and Luber, Brandon and Wang, Hao and Chen, Yan and Zhu, Yezi and Silberstein, John L and Taylor, Maritza N and Maughan, Benjamin L and Denmeade, Samuel R and Pienta, Kenneth J and Paller, Channing J and Carducci, Michael A and Eisenberger, Mario A and Luo, Jun
Journal of Clinical Oncology, ISSN 0732-183X, 07/2017, Volume 35, Issue 19, pp. 2149 - 2156
Purpose We reported previously that the detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells (CTCs) correlated with poor... 
TRIALS WORKING GROUP | DESIGN | AR-V7 | ONCOLOGY | RECOMMENDATIONS | Prospective Studies | Phenylthiohydantoin - therapeutic use | Prostatic Neoplasms, Castration-Resistant - blood | Humans | RNA, Messenger - genetics | Androstenes - therapeutic use | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Prostate-Specific Antigen - blood | Prostatic Neoplasms, Castration-Resistant - genetics | Disease-Free Survival | Neoplasm Metastasis | RNA, Messenger - blood | Receptors, Androgen - genetics | Protein Isoforms | Aged | Kallikreins - blood | Cohort Studies | Genitourinary | Systemic Therapy | Cancer Biomarkers | Translational Oncology | ORIGINAL REPORTS
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5. Full Text FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
by Huh, Joo Young and Panagiotou, Grigorios and Mougios, Vassilis and Brinkoetter, Mary and Vamvini, Maria T and Schneider, Benjamin E and Mantzoros, Christos S
Metabolism, ISSN 0026-0495, 2012, Volume 61, Issue 12, pp. 1725 - 1738
Abstract Objective In mouse, PGC1-α overexpression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as... 
Endocrinology & Metabolism | FNDC5 | Irisin | Exercise | Weight loss | ENERGY DEPRIVATION ALTERS | LEPTIN | BROWN ADIPOSE-TISSUE | INDEPENDENT MANNER | SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | ACTIVIN-A | OBESITY | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | Bariatric Surgery | Body Mass Index | Cross-Sectional Studies | Obesity, Morbid - surgery | Humans | Middle Aged | Gene Expression Regulation | Male | Adenosine Triphosphate - blood | Biomarkers - blood | Athletes | Fibronectins - blood | Fibronectins - metabolism | Lipolysis | RNA, Messenger - blood | Weight Loss | Glycolysis | Adult | Female | Fibronectins - genetics | Hormones - blood | Obesity, Morbid - blood | Somatotropin | Messenger RNA | Genetic research | Physiological aspects | Protein binding | Obesity | Physical training | Insulin-like growth factor I | Muscles | mRNA | Glucose | Hormones | Regression analysis | Gene expression | Metabolism | Insulin | Cholesterol | Adiponectin | Membrane proteins | ghrelin | Body mass | Metabolites | Surgery | Running | ATP | Age
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6. Full Text exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes
by Li, Shengli and Li, Yuchen and Chen, Bing and Zhao, Jingjing and Yu, Shulin and Tang, Yan and Zheng, Qiupeng and Li, Yan and Wang, Peng and He, Xianghuo and Huang, Shenglin
Nucleic Acids Research, ISSN 0305-1048, 01/2018, Volume 46, Issue D1, pp. D106 - D112
Abstract Exosomes, which are nanosized endocytic vesicles that are secreted by most cells, contain an abundant cargo of different RNA species that can modulate... 
DIAGNOSIS | PROJECT | CANCER-PATIENTS | EXTRACELLULAR VESICLES | BIOGENESIS | CIRCULAR RNAS | MARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETION | RNA, Messenger - blood | Sequence Analysis, RNA | Humans | RNA, Messenger - genetics | Exosomes - genetics | RNA, Long Noncoding - blood | RNA, Long Noncoding - genetics | Internet | Databases, Nucleic Acid | RNA - blood | RNA - genetics | Database Issue
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7. Full Text Identification of context-dependent expression quantitative trait loci in whole blood
by Pital-Zhernakova, Daria and Deelen, Patrick and Vermaat, Martijn and van Iterson, Maarten and van Galen, Michiel and Arinarto, Wibowo and van 't Hof, Peter and Mei, Hailiang and van Dijk, Freerk and Westra, Harm-Jan and Bonder, Marc Jan and van Rooij, Jeroen and Verkerk, Marijn and Jhamai, P. Mila and Moed, Matthijs and Kielbasa, Szymon M and Bot, Jan and Nooren, Irene and Pool, Rene and van Dongen, Jenny and Hottenga, Jouke J and Stehouwer, Coen D. A and van der Kallen, Carla J. H and Schalkwijk, Casper G and Zhernakova, Alexana and Li, Yang and Tigchelaar, Ettje F and de Klein, Niek and Beekman, Marian and Deelen, Joris and van Heemst, Diana and van den Berg, Leonard H and Hofman, Albert and Uitterlinden, Ane G and van Greevenbroek, Marleen M. J and Veldink, Jan H and Boomsma, Dorret I and van Duijn, Cornelia M and Wijmenga, Cisca and Slagboom, P. Eline and Swertz, Morris A and Isaacs, Aaron and van Meurs, Joyce B. J and Jansen, Rick and Heijmans, Bastiaan T and t Hoen, Peter A. C and Franke, Lude
Nature Genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 1, pp. 139 - 145
Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology1,2. Expression quantitative trait loci (eQTLs)... 
OBESITY | VARIANTS | GENETICS & HEREDITY | GENE-EXPRESSION | ENRICHMENT | CELL | ASSOCIATION | EQTLS | Genetic Predisposition to Disease | Humans | Middle Aged | RNA, Messenger - genetics | Male | Gene Expression Profiling | Regulatory Sequences, Nucleic Acid - genetics | RNA, Messenger - blood | Blood Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Female | High-Throughput Nucleotide Sequencing | Cell Lineage - genetics | Cohort Studies | Quantitative Trait Loci - genetics | Quantitative trait loci | Gene expression | Analysis | Blood | Multiple sclerosis | Disease | Research & development--R&D | Genomics | Neutrophils | Genomes | Grants | Inflammatory bowel disease | Consortia | Hypotheses | Rheumatoid arthritis | Infrastructure | Research centers | Binding sites
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8. Full Text Circulating long RNAs in serum extracellular vesicles: Their characterization and potential application as biomarkers for diagnosis of colorectal cancer
by Dong, Lei and Lin, Wanrun and Qi, Peng and Xu, Mi-Die and Wu, Xiaoben and Ni, Shujuan and Huang, Dan and Weng, Wei-Wei and Tan, Cong and Sheng, Weiqi and Zhou, Xiaoyan and Du, Xiang
Cancer Epidemiology Biomarkers and Prevention, ISSN 1055-9965, 07/2016, Volume 25, Issue 7, pp. 1158 - 1166
Background: Long noncoding RNA (lncRNA) and mRNAs are long RNAs (>= 200 nucleotides) compared with miRNAs. In blood, long RNAs may be protected by serum... 
NONCODING RNA | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PLASMA | MESSENGER-RNA | ONCOLOGY | MARKERS | MICRORNAS | IDENTIFICATION | BREAST | NUCLEIC-ACIDS | BLOOD | TOOL | Exosomes - metabolism | Colorectal Neoplasms - blood | Colorectal Neoplasms - genetics | Humans | Middle Aged | RNA, Messenger - genetics | Male | RNA, Long Noncoding - blood | RNA, Long Noncoding - genetics | Case-Control Studies | Colorectal Neoplasms - diagnosis | Biomarkers, Tumor - blood | RNA, Messenger - blood | Extracellular Vesicles - genetics | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Aged | Biomarkers, Tumor - genetics | Cohort Studies
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9. Full Text Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
by Fisher, Ffolliott M and Chui, Patricia C and Antonellis, Patrick J and Bina, Holly A and Kharitonenkov, Alexei and Flier, Jeffrey S and Maratos-Flier, Eleftheria
Diabetes, ISSN 0012-1797, 11/2010, Volume 59, Issue 11, pp. 2781 - 2789
OBJECTIVE-Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 improve glucose... 
BETA-KLOTHO | PPAR-ALPHA | ADIPOCYTES | RECEPTOR INTERACTION | FIBROBLAST-GROWTH-FACTOR-21 | INSULIN-RESISTANCE | METABOLIC-ACTIVITY | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | MICE | FGF21 | Adipose Tissue - physiology | Injections, Intravenous | Humans | Mice, Inbred C57BL | RNA, Messenger - genetics | Fibroblast Growth Factors - pharmacology | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Obesity - blood | Recombinant Proteins - blood | Animals | RNA, Messenger - blood | Liver - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Fibroblast Growth Factors - administration & dosage | Fibroblast Growth Factors - blood | Liver - physiology | Mice, Obese | Signal Transduction - physiology | Mice | Adipose Tissue - drug effects | Drug Resistance | Fibroblast Growth Factors - physiology | RNA, Messenger - drug effects | Obesity | Care and treatment | Physiological aspects | Triglycerides | Fibroblast growth factors | Diabetes | Glucose | Fatty acids | Health aspects | Dextrose | Risk factors | Metabolism
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10. Full Text Circulating RNAs as new biomarkers for detecting pancreatic cancer
by Kishikawa, Takahiro and Otsuka, Motoyuki and Ohno, Motoko and Yoshikawa, Takeshi and Takata, Akemi and Koike, Kazuhiko
World Journal of Gastroenterology, ISSN 1007-9327, 07/2015, Volume 21, Issue 28, pp. 8527 - 8540
Pancreatic cancer remains difficult to treat and has a high mortality rate. It is difficult to diagnose early, mainly due to the lack of screening imaging... 
Biomarkers | MicroRNA | Non-coding RNA | Pancreatic cancer | Early detection | DUCTAL ADENOCARCINOMA | SMALL NUCLEAR | PERIPHERAL-BLOOD | MICRORNA EXPRESSION PROFILES | LONG NONCODING RNA | POOR-PROGNOSIS | TRANSCRIPTASE MESSENGER-RNA | APOPTOTIC BODIES | GASTROENTEROLOGY & HEPATOLOGY | REAL-TIME QUANTIFICATION | TUMOR-MARKER | Pancreatic Neoplasms - blood | Predictive Value of Tests | Prognosis | Early Detection of Cancer - methods | Humans | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreatic Neoplasms - genetics | RNA, Untranslated - genetics | RNA, Untranslated - blood | RNA - genetics | Biomarkers, Tumor - blood | Molecular Diagnostic Techniques | RNA, Messenger - blood | Biomarkers, Tumor - genetics | RNA - blood | Review
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