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Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 262 - 269
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 78 - 83
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)(1-6). Clearance of SCs in a progeroid mouse model... 
MEDICINE, RESEARCH & EXPERIMENTAL | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | P16(INK4A) | CELLULAR SENESCENCE | FAMILY | CELL BIOLOGY | POTENT | IN-VIVO | IONIZING-RADIATION | INHIBITOR | EXPRESSION | Whole-Body Irradiation | Apoptosis - drug effects | Humans | bcl-X Protein - genetics | Hematopoietic Stem Cells - pathology | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Gene Knockdown Techniques | Myoblasts - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - drug effects | Cellular Senescence | Ganciclovir - pharmacology | Antineoplastic Agents - pharmacology | Colony-Forming Units Assay | RNA, Messenger - drug effects | Hematopoietic Stem Cells - drug effects | Cell Line | Cell Survival - drug effects | Antiviral Agents - pharmacology | Aniline Compounds - pharmacology | Rejuvenation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Myoblasts - pathology | Sulfonamides - pharmacology | Blotting, Western | B-Lymphocytes - drug effects | Animals | Cell Cycle | Microscopy | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice | DNA Damage | Proto-Oncogene Proteins c-bcl-2 - genetics | Physiological aspects | Aging | Genetic aspects | Research | Hematopoietic stem cells | Cells | Bone marrow | Cytotoxicity | Senescence | Molecular biology | Stem cells | Apoptosis | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2017, Volume 377, Issue 18, pp. 1723 - 1732
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E530 - E541
To better understand the role of irisin in humans, we examined the effects of irisin in human primary adipocytes and fresh human subcutaneous white adipose... 
Irisin | Thermogenesis | Human white adipose tissue | Brown adipose tissue | Adipocytes browning | Osteogenesis | Adipogenesis | Immunohistochemistry | Thermogenesis - genetics | Up-Regulation | Phosphoproteins - drug effects | Extracellular Signal-Regulated MAP Kinases - drug effects | Adipocytes, Brown - metabolism | Adipogenesis - drug effects | Humans | Middle Aged | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Young Adult | Adipocytes, White - drug effects | Exercise | Cell Respiration - drug effects | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Adipogenesis - genetics | Real-Time Polymerase Chain Reaction | Osteogenesis - genetics | STAT3 Transcription Factor - metabolism | RNA, Messenger - drug effects | Uncoupling Protein 1 - drug effects | Fibronectins - pharmacology | Signal Transduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Subcutaneous Fat - cytology | Blotting, Western | Obesity - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | Cell Differentiation - drug effects | STAT3 Transcription Factor - drug effects | Adolescent | Aged | Thermogenesis - drug effects | Osteoblasts - metabolism | Adipocytes, White - metabolism | Fat cells | Growth | Physiological aspects | Bones | Physiological research | Research | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 257 - 267
Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression at the level of translation initiation. This complex is regulated... 
FACTOR EIF-4E | HUMAN-DISEASE | MALIGNANT-TRANSFORMATION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MTOR INHIBITORS | CANCER-THERAPY | CELL BIOLOGY | Protein Binding - genetics | Humans | Nitro Compounds - chemistry | Eukaryotic Initiation Factor-4E - metabolism | Peptide Fragments - pharmacology | Eukaryotic Initiation Factor-4G - drug effects | Eukaryotic Initiation Factor-4G - metabolism | Fluorescence Polarization Immunoassay - methods | Thiazoles - isolation & purification | Antineoplastic Agents - isolation & purification | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Protein Biosynthesis - genetics | Gene Expression Regulation, Neoplastic - drug effects | Eukaryotic Initiation Factor-4E - genetics | Peptide Fragments - genetics | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Drug Evaluation, Preclinical - methods | Oncogenes - genetics | Peptide Fragments - metabolism | Jurkat Cells | RNA, Messenger - genetics | Hydrazones | Models, Molecular | Antineoplastic Agents - chemistry | Cell Transformation, Neoplastic - metabolism | Eukaryotic Initiation Factor-4E - drug effects | Nitro Compounds - isolation & purification | Animals | Cell Line, Tumor | Oncogenes - drug effects | Feedback, Physiological - drug effects | Protein Biosynthesis - drug effects | Thiazoles - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mice | Thiazoles - pharmacology | Cell Transformation, Neoplastic - drug effects | Feedback, Physiological - physiology | Cell Line, Transformed | Index Medicus | Peptide Fragments | Protein Biosynthesis | Gene Expression Regulation, Neoplastic | Eukaryotic Initiation Factor-4E | Chemical Sciences | Fluorescence Polarization Immunoassay | Life Sciences | Thiazoles | Drug Evaluation, Preclinical | Feedback, Biochemical | Oncogenes | Analytical chemistry | Biochemistry, Molecular Biology | Antineoplastic Agents | Organic chemistry | Eukaryotic Initiation Factor-4G | Cell Transformation, Neoplastic | Nitro Compounds | Protein Binding | RNA, Messenger
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue 6, pp. 1311 - 1316
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the... 
TRIAL | PATHOGENESIS | CRITERIA | CYTOKINES | PLACEBO | DISEASE | GENE-EXPRESSION | METHOTREXATE | RHEUMATOLOGY | COMBINATION | CP-690,550 | Humans | Middle Aged | STAT Transcription Factors - metabolism | Chemokines - drug effects | Male | Matrix Metalloproteinase 3 - drug effects | Synovial Membrane - drug effects | Methotrexate - therapeutic use | RNA, Messenger - metabolism | STAT Transcription Factors - drug effects | Arthritis, Rheumatoid - metabolism | Janus Kinase 1 - metabolism | Piperidines - pharmacology | Arthritis, Rheumatoid - drug therapy | Adult | Female | Antirheumatic Agents - pharmacology | Drug Therapy, Combination | Pyrroles - therapeutic use | Matrix Metalloproteinase 1 - genetics | Antirheumatic Agents - therapeutic use | RNA, Messenger - drug effects | Matrix Metalloproteinase 1 - drug effects | Double-Blind Method | Matrix Metalloproteinase 3 - metabolism | Treatment Outcome | Pyrimidines - pharmacology | Chemokines - genetics | Janus Kinase 1 - drug effects | Synovial Membrane - metabolism | Pyrroles - pharmacology | Signal Transduction - drug effects | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Aged | Chemokines - metabolism | Protein Kinase Inhibitors - pharmacology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Tofacitinib | Rheumatoid arthritis | Dosage and administration | Genetic aspects | Research | Gene expression | Risk factors | Index Medicus | Basic and Translational Research | 1506
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 6, pp. 403 - 416
AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and whole-body energy metabolism. We have identified a thienopyridone family... 
SIGNALING | SKELETAL-MUSCLE | PROTEIN-KINASE CASCADE | FATTY-ACID OXIDATION | MALONYL-COA | GLYCOGEN-PHOSPHORYLASE | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | ACETYL-COA CARBOXYLASE | CELLULAR-ENERGY | ISOLATED RAT HEPATOCYTES | GLOBULAR DOMAIN | CELL BIOLOGY | Enzyme Activators - pharmacology | Glucose-6-Phosphatase - genetics | Thiophenes - therapeutic use | Metformin - therapeutic use | Molecular Weight | Fatty Acid Synthases - metabolism | Enzyme Activators - therapeutic use | Humans | Phosphoenolpyruvate Carboxykinase (GTP) - drug effects | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Multienzyme Complexes - metabolism | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | RNA, Messenger - metabolism | Metabolic Syndrome - drug therapy | Pyrones - pharmacology | AMP-Activated Protein Kinases | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Dose-Response Relationship, Drug | Pyrones - chemistry | Enzyme Activators - chemistry | Fatty Acid Synthases - genetics | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Fatty Acid Synthases - drug effects | RNA, Messenger - drug effects | Cell Line | Metformin - chemistry | Metformin - pharmacology | RNA, Messenger - genetics | Rats | Thiophenes - pharmacology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Glucose-6-Phosphatase - metabolism | Glucose-6-Phosphatase - drug effects | Animals | Protein-Serine-Threonine Kinases - drug effects | Pyrones - therapeutic use | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - drug therapy | In Vitro Techniques | Thiophenes - chemistry | Enzyme Activation - physiology | Multienzyme Complexes - drug effects | Type 2 diabetes | Synthesis | Analysis | Insulin resistance | Lipids | Triglycerides | Glucose | Gene expression | Protein kinases | Fatty acids | Dextrose | Index Medicus
Journal Article