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1. Full Text Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches
by Zarovni, Natasa and Corrado, Antonietta and Guazzi, Paolo and Zocco, Davide and Lari, Elisa and Radano, Giorgia and Muhhina, Jekatarina and Fondelli, Costanza and Gavrilova, Julia and Chiesi, Antonio
Methods, ISSN 1046-2023, 10/2015, Volume 87, pp. 46 - 58
Clinical implementation of exosome based diagnostic and therapeutic applications is still limited by the lack of standardized technologies that integrate... 
Biomarkers | Plasma | Immunoaffinity isolation | Exosomes | Quantitative in vitro assays | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | MICROVESICLES | PROTEOMIC ANALYSIS | MICROPARTICLES | Enzyme-Linked Immunosorbent Assay - methods | Colonic Neoplasms - genetics | Humans | Colonic Neoplasms - diagnosis | Male | RNA, Neoplasm - isolation & purification | Ultracentrifugation | Prostatic Neoplasms - diagnosis | RNA, Neoplasm - blood | Prostatic Neoplasms - genetics | Biological Transport | Polymerase Chain Reaction | Prostatic Neoplasms - blood | Neoplasm Proteins - genetics | Prostatic Neoplasms - pathology | Cell Fractionation - methods | Biomarkers, Tumor - isolation & purification | Biomarkers, Tumor - blood | Neoplasm Proteins - isolation & purification | Colonic Neoplasms - pathology | Neoplastic Cells, Circulating | Cell Line, Tumor | Colonic Neoplasms - blood | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Exosomes - chemistry | Proteins | Nucleic acids | Precipitation (Meteorology) | Analysis | Protein binding
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2. Full Text Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes
by Kanwar, Shailender Singh and Dunlay, Christopher James and Simeone, Diane M and Nagrath, Sunitha
Lab on a Chip, ISSN 1473-0197, 06/2014, Volume 14, Issue 11, pp. 1891 - 1900
Membrane bound vesicles, including microvesicles and exosomes, are secreted by both normal and cancerous cells into the extracellular space and in blood... 
CELLS | CHEMISTRY, ANALYTICAL | PANCREATIC-CANCER | BIOCHEMICAL RESEARCH METHODS | MICROVESICLES | NANOSCIENCE & NANOTECHNOLOGY | DIAGNOSTIC BIOMARKERS | OVARIAN-CANCER | TUMOR-DERIVED EXOSOMES | CHEMISTRY, MULTIDISCIPLINARY | MESSENGER-RNAS | EXTRACELLULAR VESICLES | MEMBRANE-VESICLES | MICRORNA SIGNATURES | Exosomes - metabolism | Microfluidic Analytical Techniques - methods | Pancreatic Neoplasms - blood | Humans | Microfluidic Analytical Techniques - instrumentation | Male | Cell-Derived Microparticles - chemistry | Lab-On-A-Chip Devices | RNA, Neoplasm - isolation & purification | RNA, Neoplasm - blood | MicroRNAs - isolation & purification | Cell-Derived Microparticles - metabolism | Exosomes - chemistry | MicroRNAs - blood | Cell-Derived Microparticles - ultrastructure | Exosomes - ultrastructure | Platforms | Vesicles | Biomarkers | Circulating | Devices | Patients | Microfluidics | Cancer
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3. Full Text Integrated systems for exosome investigation
by Peterson, Maureen F and Otoc, Nicole and Sethi, Jasmine K and Gupta, Archana and Antes, Travis J
Methods, ISSN 1046-2023, 10/2015, Volume 87, pp. 31 - 45
Extracellular vesicles, including exosomes, are currently being investigated to better understand their biogenesis and biological functions. There is also a... 
Extracellular vesicles | miRNA biomarkers | Nanobiomedicine | Liquid biopsy | Exosomes | Oncosomes | MiRNA biomarkers | RNA | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | MICROVESICLES | MIRNA SIGNATURE | MICRORNAS | DELIVERY | BIOMARKERS | URINARY EXOSOMES | CELL-DERIVED EXOSOMES | Oligonucleotide Array Sequence Analysis | Humans | Cell Fractionation - methods | Neoplasms - diagnosis | RNA, Neoplasm - isolation & purification | Ultracentrifugation | Microscopy, Electron | Biomarkers, Tumor - isolation & purification | Neoplasms - chemistry | MicroRNAs - isolation & purification | Ultrafiltration | Neoplasms - genetics | Neoplasm Proteins - isolation & purification | Flocculation | Reagent Kits, Diagnostic | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Exosomes - chemistry | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | Chromatography, Gel | Neoplasm Proteins - genetics | Neoplasms - pathology | Cell Fractionation - instrumentation | Alzheimer's disease | Investigations | MicroRNA
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4. Full Text Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
by Wolff, Erika M and Chihara, Yoshitomo and Pan, Fei and Weisenberger, Daniel J and Siegmund, Kimberly D and Sugano, Kokichi and Kawashima, Kiyotaka and Laird, Peter W and Jones, Peter A and Liang, Gangning
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 8169 - 8178
Urothelial cancer (UC) develops along two different genetic pathways, resulting in noninvasive or invasive tumors. However, it is unknown whether there are... 
BLADDER-CANCER | THERAPY | HYPERMETHYLATION | LINE-1 HYPOMETHYLATION | GENE | ONCOLOGY | PROGRESSIVE INCREASES | CPG ISLAND | EXPRESSION | CARCINOMA | FREQUENT FGFR3 MUTATIONS | Chromosomes, Human, X - genetics | Epigenesis, Genetic | Humans | DNA, Neoplasm - isolation & purification | Exons - genetics | DNA Methylation - genetics | RNA, Neoplasm - isolation & purification | Precancerous Conditions - genetics | Urothelium - pathology | Urologic Neoplasms - pathology | Cystectomy | Urinary Bladder Neoplasms - genetics | Urologic Neoplasms - genetics | Neoplasm Invasiveness - pathology | Lymphatic Metastasis - pathology | Lymphatic Metastasis - genetics | Urinary Bladder Neoplasms - pathology | RNA, Neoplasm - genetics | Female | DNA, Neoplasm - genetics | Neoplasm Staging | Cluster Analysis
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5. Full Text KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue
by Mostert, Bianca and Jiang, Yuqiu and Sieuwerts, Anieta M and Wang, Haiying and Bolt‐de Vries, Joan and Biermann, Katharina and Kraan, Jaco and Lalmahomed, Zarina and Galen, Anne and Weerd, Vanja and Spoel, Petra and Ramírez‐Moreno, Raquel and Verhoef, Cornelis and IJzermans, Jan N.M and Wang, Yixin and Gratama, Jan‐Willem and Foekens, John A and Sleijfer, Stefan and Martens, John W.M
International Journal of Cancer, ISSN 0020-7136, 07/2013, Volume 133, Issue 1, pp. 130 - 141
Although anti‐EGFR therapy has established efficacy in metastatic colorectal cancer, only 10‐20% of unselected patients respond. This is partly due to KRAS and... 
KRAS | BRAF | colorectal cancer | circulating tumor cells | COLD‐PCR | COLD-PCR | CANCER PATIENTS | SURVIVAL | RAS | BREAST-CANCER | LIVER METASTASES | PANITUMUMAB | MESSENGER-RNA | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | RNA, Messenger - isolation & purification | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Liver Neoplasms - therapy | RNA, Neoplasm - isolation & purification | Polymerase Chain Reaction - methods | Colorectal Neoplasms - therapy | Aged, 80 and over | Adult | Female | Liver Neoplasms - secondary | Liver Neoplasms - genetics | HCT116 Cells | DNA, Neoplasm - isolation & purification | Proto-Oncogene Proteins - genetics | Lymphatic Metastasis | Proto-Oncogene Proteins B-raf - genetics | Alleles | Neoplastic Cells, Circulating | Aged | Mutation | Colorectal Neoplasms - pathology | Neoplasm Staging | Proteins | Liver cancer | RNA | Gene mutations | Gastrointestinal diseases | Denaturation | Colorectal cancer | Genetic aspects | Metastasis | Deoxyribonucleic acid--DNA | Tumors | Biopsy
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6. Full Text An optimized procedure for exosome isolation and analysis using serum samples: Application to cancer biomarker discovery
by Li, Mu and Rai, Alex J and Joel DeCastro, G and Zeringer, Emily and Barta, Timothy and Magdaleno, Susan and Setterquist, Robert and Vlassov, Alexander V
Methods, ISSN 1046-2023, 10/2015, Volume 87, pp. 26 - 30
Exosomes are RNA and protein-containing nanovesicles secreted by all cell types and found in abundance in body fluids, including blood, urine and cerebrospinal... 
Biomarker | Exosome | miRNA | microRNA | Extracellular vesicle | Prostate cancer | Blood | MicroRNA | MiRNA | CIRCULATING MICRORNAS | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | BIOCHEMICAL RESEARCH METHODS | Prostate-Specific Antigen - genetics | Gene Expression | Prostatic Neoplasms - chemistry | Prostatic Neoplasms - surgery | Humans | Male | RNA, Neoplasm - isolation & purification | Prostatic Neoplasms - diagnosis | Reverse Transcriptase Polymerase Chain Reaction | Biomarkers, Tumor - isolation & purification | RNA, Neoplasm - blood | Case-Control Studies | Prostate-Specific Antigen - blood | Biomarkers, Tumor - blood | Prostatic Neoplasms - genetics | RNA, Neoplasm - genetics | Prostatectomy | Biomarkers, Tumor - genetics | Exosomes - chemistry | MicroRNAs - blood | MicroRNAs - genetics | Indicators and Reagents - chemistry | Cancer | Metastasis | Chemical tests and reagents | Cells
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7. Full Text Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
by Hennessy, Bryan T and Gonzalez-Angulo, Ana-Maria and Stemke-Hale, Katherine and Gilcrease, Michael Z and Krishnamurthy, Savitri and Lee, Ju-Seog and Fridlyand, Jane and Sahin, Aysegul and Agarwal, Roshan and Joy, Corwin and Liu, Wenbin and Stivers, David and Baggerly, Keith and Carey, Mark and Lluch, Ana and Monteagudo, Carlos and He, Xiaping and Weigman, Victor and Fan, Cheng and Palazzo, Juan and Hortobagyi, Gabriel N and Nolden, Laura K and Wang, Nicholas J and Valero, Vicente and Gray, Joe W and Perou, Charles M and Mills, Gordon B
Cancer Research, ISSN 0008-5472, 05/2009, Volume 69, Issue 10, pp. 4116 - 4124
Metaplastic breast cancers (MBC) are aggressive, chemo-resistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and... 
ADJUVANT CHEMOTHERAPY | DNA COPY NUMBER | PROTEIN | ONCOLOGY | PATHWAY | KINASE | ADENOCARCINOMA CELLS | MICROARRAYS | MUTATIONS | EXPRESSION | METAPLASTIC CARCINOMAS | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Profiling | RNA, Neoplasm - isolation & purification | Proto-Oncogene Proteins c-akt - genetics | Female | Transcription, Genetic | Sarcoma - genetics | Breast Neoplasms - classification | PTEN Phosphohydrolase - genetics | Epithelial Cells - pathology | Proto-Oncogene Proteins - genetics | Sarcoma - pathology | Phosphatidylinositol 3-Kinases - genetics | Metaplasia | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Comparative Genomic Hybridization | Receptors, Steroid - genetics | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | DNA, Neoplasm - genetics | Mesenchymal Stromal Cells - pathology | Mutation | Cohort Studies
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8. Full Text Integrated profiling of basal and luminal breast cancers
by Adelaide, J and Finetti, P and Bekhouche, I and Repellini, L and Geneix, J and Sircoulomb, F and Charafe-Jauffret, E and Cervera, N and Desplans, J and Parzy, D and Schoenmakers, E.F.P.M and Viens, P and Jacquemier, J and Birnbaum, D and Bertucci, F and Chaffanet, M
Cancer Research, ISSN 0008-5472, 2007, Volume 67, Issue 24, pp. 11565 - 11575
Basal and luminal are two molecular subtypes of breast cancer with opposite histoclinical features. We report a combined, high-resolution analysis of genome... 
MOLECULAR SUBTYPES | STEM-CELLS | ONCOLOGY | GENE-EXPRESSION PATTERNS | COPY NUMBER | PROTEIN EXPRESSION | DNA AMPLIFICATION | CARCINOMAS | TUMOR | COMPARATIVE GENOMIC HYBRIDIZATION | CELL-LINES | Breast Neoplasms - classification | Breast Neoplasms - surgery | Nucleic Acid Hybridization | Adenocarcinoma - pathology | Oligonucleotide Array Sequence Analysis | Humans | DNA, Neoplasm - isolation & purification | In Situ Hybridization, Fluorescence | Chromosome Mapping | Chromosomes, Human, Pair 8 | Gene Expression Profiling | RNA, Neoplasm - isolation & purification | Breast Neoplasms - genetics | Gene Amplification | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Female | Adenocarcinoma - genetics | DNA, Neoplasm - genetics | Adenocarcinoma - surgery
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9. Full Text Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation
by Hua Gao and Goutam Chakraborty and Ai Ping Lee-Lim and Konstantinos J. Mavrakis and Hans-Guido Wendel and Filippo G. Giancotti
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16532 - 16537
We have developed a screening platform for the isolation of genetic entities involved in metastatic reactivation. Retroviral libraries of cDNAs from fully... 
Dormancy | MicroRNA | Lungs | Libraries | Metastasis | Lesions | Genetic screening | Cells | Tumors | Cancer | SURVIVAL | ACTIVATION | microRNA library screen | MULTIDISCIPLINARY SCIENCES | forward genetic screens | TUMOR | MECHANISMS | shRNA library screen | SHRNA LIBRARIES | DORMANCY | cDNA library screen | BREAST-CANCER CELLS | LUNG-CANCER | metastatic reactivation | IN-VIVO | PROGRESSION | Neoplasm Transplantation | RNA, Small Interfering - genetics | Proviruses - isolation & purification | Genes, Neoplasm | Neoplasm Proteins - physiology | DNA, Complementary - genetics | Gene Expression Regulation, Neoplastic | RNA, Neoplasm - isolation & purification | MicroRNAs - isolation & purification | Lung Neoplasms - secondary | Proviruses - genetics | Retroviridae - genetics | Mammary Neoplasms, Experimental - pathology | Female | Neoplasm Proteins - genetics | Carcinoma - secondary | High-Throughput Screening Assays - methods | Transduction, Genetic | Gene Library | Retroviridae - isolation & purification | Virus Integration | Genetic Vectors - genetics | Genetic Vectors - isolation & purification | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | DNA, Neoplasm - genetics | Oncology, Experimental | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Methods | DNA sequencing | Biological Sciences
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10. Full Text Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature
by Charafe-Jauffret, E and Ginestier, C and Iovino, F and Wicinski, J and Cervera, N and Finetti, P and Hur, MH and Diebel, ME and Monville, F and Dutcher, J and Brown, M and Viens, P and Xerri, L and Bertucci, F and Stassi, G and Dontu, G and Birnbaum, D and Wicha, MS
CANCER RESEARCH, ISSN 0008-5472, 02/2009, Volume 69, Issue 4, pp. 1302 - 1313
Tumors may be initiated and maintained by a cellular subcomponent that displays stem cell properties. We have used the expression of aldehyde dehydrogenase as... 
SIDE POPULATION | ONCOLOGY | ALDEHYDE DEHYDROGENASE-ACTIVITY | PROSTATE-CANCER | ACUTE MYELOID-LEUKEMIA | TUMORIGENICITY | IDENTIFICATION | EXPRESSION | CARCINOMA | INTERLEUKIN-8 | IN-VITRO PROPAGATION | Oligonucleotide Array Sequence Analysis | Humans | Receptors, Interleukin-8A - genetics | Homeostasis | Gene Expression Profiling | RNA, Neoplasm - isolation & purification | Stem Cells - cytology | Flow Cytometry | Biomarkers, Tumor - metabolism | Female | Cell Line | Breast - cytology | RNA, Messenger - genetics | Aldehyde Dehydrogenase - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Mice, Inbred NOD | Stem Cells - physiology | Mice | Life Sciences | Cellular Biology | Cancer | breast cancer | cancer stem cells | IL8 | metastasis | cell line
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11. Full Text Gene Expression Profiles of Primary Breast Tumors Maintained in Distant Metastases
by Britta Weigelt and Annuska M. Glas and Lodewyk F. A. Wessels and Anke T. Witteveen and Johannes L. Peterse and Laura J. van't Veer
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2003, Volume 100, Issue 26, pp. 15901 - 15905
It has been debated for decades how cancer cells acquire metastatic capability. It is unclear whether metastases are derived from distinct subpopulations of... 
Tumor cell line | Biological Sciences | RNA | Complementary DNA | Breast neoplasms | Breast cancer | Metastasis | Gene expression | Human genetics | Tumors | Cancer | CELLS | SIGNATURE | CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | MICROARRAY DATA | GROWTH | Lung Neoplasms - genetics | Oligonucleotide Array Sequence Analysis | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Gene Expression Profiling | Lymphatic Metastasis | RNA, Neoplasm - isolation & purification | Ovarian Neoplasms - genetics | Neoplasm Metastasis - genetics | Ovarian Neoplasms - secondary | Breast Neoplasms - genetics | Lung Neoplasms - secondary | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Female | Genetics | Breast tumors | Research
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12. Full Text Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma
by Childs, Geoffrey and Fazzari, Melissa and Kung, Gloria and Kawachi, Nicole and Brandwein-Gensler, Margaret and McLemore, Michael and Chen, Quan and Burk, Robert D and Smith, Richard V and Prystowsky, Michael B and Belbin, Thomas J and Schlecht, Nicolas F
American Journal of Pathology, The, ISSN 0002-9440, 2009, Volume 174, Issue 3, pp. 736 - 745
Small noncoding microRNAs (miRNAs) have been shown to be abnormally expressed in every tumor type examined. The importance of miRNAs as potential cancer... 
Pathology | TARGET | LUNG-CANCER | MOLECULAR CLASSIFICATION | PROFILES | METASTASIS | CDNA MICROARRAYS | ORAL-CANCER | PATHOLOGY | IDENTIFICATION | MICROARRAY ANALYSIS | HUMAN PAPILLOMAVIRUS INFECTION | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Survivors | Male | Reference Values | RNA, Neoplasm - isolation & purification | Head and Neck Neoplasms - pathology | MicroRNAs - isolation & purification | Carcinoma, Squamous Cell - mortality | Polymerase Chain Reaction | Survival Analysis | RNA, Neoplasm - genetics | Female | Head and Neck Neoplasms - genetics | MicroRNAs - genetics | Head and Neck Neoplasms - mortality | Neoplasm Staging | Regular
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13. Full Text CSCD: a database for cancer-specific circular RNAs
by Xia, Siyu and Feng, Jing and Chen, Ke and Ma, Yanbing and Gong, Jing and Cai, Fangfang and Jin, Yuxuan and Gao, Yang and Xia, Linjian and Chang, Hong and Wei, Lei and Han, Leng and He, Chunjiang
Nucleic Acids Research, ISSN 0305-1048, 01/2018, Volume 46, Issue D1, pp. D925 - D929
Abstract Circular RNA (circRNA) is a large group of RNA family extensively existed in cells and tissues. High-throughput sequencing provides a way to view... 
BIOMARKER | STAR | EFFICIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | REVEALS | Cell Line | Oncogene Proteins, Fusion - metabolism | MicroRNAs - antagonists & inhibitors | Response Elements | Humans | Data Collection | RNA, Neoplasm - isolation & purification | Open Reading Frames - genetics | Biomarkers, Tumor | Forecasting | RNA - genetics | RNA - isolation & purification | RNA Splicing | Neoplasms - genetics | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | Neoplasms - pathology | Binding Sites | Gene Expression Regulation, Neoplastic - genetics | RNA-Binding Proteins - metabolism | Web Browser | Database Issue
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14. Full Text Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
by Zhu, Meng-Lei and Horbinski, Craig M and Garzotto, Mark and Qian, David Z and Beer, Tomasz M and Kyprianou, Natasha
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 20, pp. 7992 - 8002
Recent insights into the regulation of the androgen receptor (AR) activity led to novel therapeutic targeting of AR function in prostate cancer patients.... 
BCL-2 PHOSPHORYLATION | WEEKLY DOCETAXEL | CELLS | PREDNISONE | MITOXANTRONE | THERAPY | ONCOLOGY | MICROTUBULES | DEPRIVATION | PHASE-II | INTERMEDIATE-FILAMENTS | Taxoids - toxicity | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Reference Values | RNA, Neoplasm - isolation & purification | Tubulin - drug effects | Mitoxantrone - toxicity | Taxoids - therapeutic use | Prostatic Neop