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Journal Article
Nature, ISSN 0028-0836, 07/2007, Volume 448, Issue 7149, pp. 39 - 43
A major impediment in the treatment of neurological diseases is the presence of the blood - brain barrier, which precludes the entry of therapeutic molecules... 
IN-VIVO DELIVERY | VIRUS | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR DELIVERY | CELL-PENETRATING PEPTIDES | GENE-THERAPY | RECEPTORS | MODIFIED SIRNAS | BRAIN | INHIBITS TUMOR-GROWTH | RNA, Small Interfering - genetics | Superoxide Dismutase - genetics | Encephalitis Virus, Japanese | Humans | Glycoproteins - metabolism | Brain - virology | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Viral Proteins - metabolism | Drug Delivery Systems | Brain - metabolism | Lentivirus - genetics | Viral Proteins - administration & dosage | Neurons - metabolism | Glycoproteins - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Neurons - virology | Rabies virus - physiology | Receptors, Nicotinic - metabolism | Mice, Inbred C57BL | Oligopeptides - genetics | Gene Silencing | Viral Proteins - genetics | Recombinant Proteins - genetics | Mice, SCID | Genetic Vectors - genetics | Glycoproteins - administration & dosage | Recombinant Proteins - administration & dosage | Rabies virus - genetics | Animals | Encephalitis, Japanese - prevention & control | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | HeLa Cells | Liposomes | Superoxide Dismutase-1 | RNA, Small Interfering - administration & dosage | Blood-Brain Barrier | RNA, Small Interfering - metabolism | Brain cells | Research | Brain | Nervous system | Amino acids | Peptides | Neurological disorders | Blood | Blood-brain barrier | Ribonucleic acids | Cytokines | Genes | Central nervous system | Index Medicus
Journal Article
Journal Article
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2013, Volume 162, Issue 1, pp. 116 - 131
Journal Article
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7242, pp. 1180 - 1184
Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rational drug design. However, the transformative therapeutic... 
NONHUMAN-PRIMATES | RNA INTERFERENCE | TUMOR-NECROSIS-FACTOR | IN-VIVO DELIVERY | INHIBITION | LETHALITY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RESISTANCE | ADULT MICE | GALACTOSAMINE | Tumor Necrosis Factor-alpha - metabolism | Protein-Serine-Threonine Kinases - deficiency | RNA, Small Interfering - genetics | Substrate Specificity | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Drug Delivery Systems | Glucans - metabolism | Interleukin-1beta - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Administration, Oral | Mice, Inbred C57BL | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Enzyme Activation - drug effects | Organ Specificity | Macrophages - metabolism | Animals | MAP Kinase Signaling System - drug effects | Lipopolysaccharides - pharmacology | Inflammation - genetics | Macrophages - drug effects | Inflammation - prevention & control | Mice | RNA, Small Interfering - administration & dosage | Tumor Necrosis Factor-alpha - biosynthesis | RNA, Small Interfering - metabolism | Usage | Control | Genetic engineering | Inflammation | Genetic aspects | Research | Macrophages | Health aspects | Methods | Spleen | Tissue | E coli | Rodents | Rheumatoid arthritis | Kinases | Autoimmune diseases | Cells | Inflammatory diseases | Transfer RNA | Crohns disease | Index Medicus
Journal Article