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The New England Journal of Medicine, ISSN 0028-4793, 07/2018, Volume 379, Issue 1, pp. 11 - 21
Hereditary transthyretin amyloidosis is caused by the deposition of misfolded transthyretin proteins in peripheral nerves and other tissues. This phase 3 trial... 
MEDICINE, GENERAL & INTERNAL | POLYNEUROPATHY | EFFICACY | TAFAMIDIS | SAFETY | LATE-ONSET | NATURAL-HISTORY | PROGRESSION | Prealbumin - genetics | Humans | Middle Aged | Male | Amyloid Neuropathies, Familial - therapy | Infusions, Intravenous - adverse effects | Aged, 80 and over | Adult | Female | Prealbumin - analysis | Severity of Illness Index | Double-Blind Method | Amyloid Neuropathies, Familial - complications | RNA, Small Interfering - adverse effects | Polyneuropathies - therapy | Disease Progression | Administration, Intravenous | Polyneuropathies - etiology | RNA, Small Interfering - therapeutic use | Least-Squares Analysis | Quality of Life | Aged | RNAi Therapeutics | Amyloid Neuropathies, Familial - blood | Edema - chemically induced | Walk Test | Gait Disorders, Neurologic - etiology | Care and treatment | Amyloidosis | Genetic aspects | Intravenous administration | Gait | Cardiomyopathy | RNA-mediated interference | Liver | Diabetes mellitus | Body weight | Transthyretin | Diabetic neuropathy | Neuropathy | Gene expression | Polyneuropathy | Quality of life | Medicine | Neurology | Hospitals | Nutritional status | Pharmaceuticals | Index Medicus | Abridged Index Medicus | Assaigs clínics | Clinical trials | RNA | Amiloïdosi | Clinical Medicine | Neurologi | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
2014, ISBN 1118300394, xviii, 702 p., [24] p. of plates
"MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is... 
MicroRNAs | RNA | Genetic regulation
Book
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 31, pp. 11449 - 11454
Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based... 
Nanoparticles | Animals | Humans | Medical treatment | Liver | Small interfering RNA | Pretreatment | Dosage | Polymers | Radiotherapy | Maximum tolerance dose | Dose limiting toxicity | DNA replication | DNA proliferation | Translational medicine | maximum tolerance dose | translational medicine | SYSTEMIC DELIVERY | DESIGN | RNAI | dose limiting toxicity | MULTIDISCIPLINARY SCIENCES | INHIBITORS | TRANSLATION | Liver - pathology | Demography | Kidney - pathology | Species Specificity | Middle Aged | Polyethylene Glycols - adverse effects | Male | Nanoparticles - adverse effects | Polyethylene Glycols - therapeutic use | Complement System Proteins - metabolism | Polymers - therapeutic use | Liver - drug effects | Nanoparticles - therapeutic use | Aged, 80 and over | Female | Polymers - adverse effects | Cytokines - blood | Immunization | Kidney - drug effects | RNA, Small Interfering - pharmacokinetics | Polyethylene Glycols - pharmacokinetics | RNA, Small Interfering - adverse effects | Rats | Treatment Outcome | Haplorhini | Platelet Count | Blood Coagulation - drug effects | RNA, Small Interfering - therapeutic use | Polymers - pharmacokinetics | Aged | Mice | Drugs | Pharmaceutical research | Drug targeting | Research | Genetic translation | Health aspects | Kidneys | Correlation analysis | Toxicity | Rodents | Ribonucleic acid--RNA | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2014, Volume 111, Issue 34, pp. E3553 - E3561
MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we... 
miR-34 | Nanotechnology | MULTIDISCIPLINARY SCIENCES | MICRORNAS | MUTANT KRAS | DELIVERY | K-RAS | MOUSE MODEL | nanotechnology | TUMOR-SUPPRESSION | INTERFERENCE | SIRNA | P53 NETWORK | PROGRESSION | MicroRNAs - therapeutic use | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Antineoplastic Agents - administration & dosage | RNA, Neoplasm - metabolism | Tumor Suppressor Protein p53 - genetics | Cisplatin - administration & dosage | MAP Kinase Signaling System | Adenocarcinoma - metabolism | Nanoparticles - therapeutic use | Adenocarcinoma - genetics | Lung Neoplasms - genetics | Gene Expression | Carcinoma, Non-Small-Cell Lung - genetics | MicroRNAs - administration & dosage | Carcinoma, Non-Small-Cell Lung - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Combined Modality Therapy | Lung Neoplasms - therapy | Tumor Suppressor Protein p53 - deficiency | Mice, Knockout | Carcinoma, Non-Small-Cell Lung - therapy | Animals | Adenocarcinoma - therapy | RNA, Small Interfering - therapeutic use | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Nanoparticles - administration & dosage | Mutation | RNA, Small Interfering - administration & dosage | Cancer therapies | MicroRNAs | Lung cancer | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 11/2013, Volume 171, Issue 3, pp. 349 - 357
We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier-based system (NLCS) for efficient delivery of an anticancer drug and... 
Orthotopic lung cancer model | Nanostructured lipid carrier | Drug resistance | Imaging | Luteinizing hormone-releasing hormone (LHRH) | Inhalation | LHRH | Luteinizing hormone-releasing hormone | TARGETED THERAPY | SYSTEM | EFFICACY | TUMOR | MULTIDRUG-RESISTANT CANCER | LIPOSOMAL DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | CELL LUNG-CANCER | NANOPARTICLES | Luteinizing hormone-releasing hormone ( LHRH) | PHARMACOLOGY & PHARMACY | ANTISENSE OLIGONUCLEOTIDES | Doxorubicin - therapeutic use | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Humans | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Lipids - chemistry | Gonadotropin-Releasing Hormone - chemistry | Multidrug Resistance-Associated Proteins - genetics | Lung - metabolism | Paclitaxel - administration & dosage | Doxorubicin - administration & dosage | Lung Neoplasms - genetics | Lung - pathology | Paclitaxel - therapeutic use | Animals | Mice, Nude | RNA, Small Interfering - therapeutic use | Lung - drug effects | Cell Line, Tumor | Nanostructures - chemistry | Mice | RNA, Small Interfering - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Antimitotic agents | Care and treatment | RNA | Lung cancer | Antineoplastic agents | Cells | Cancer | Index Medicus | Animal models | inhalation | luteinizing hormone-releasing hormone (LHRH) | drug resistance | imaging | orthotopic lung cancer model
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 2014, Volume 9, Issue 8, pp. 648 - 655
Journal Article
2009, 1. Aufl., ISBN 9783642004889, xii, 193
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene... 
Small interfering RNA | metabolism | genetics | RNA Interference | MicroRNAs | Therapeutic use | Biology, life sciences | RNA | Biological interfaces | Life Sciences | Biochemistry, general | Gene Expression | Pharmacology/Toxicology | Gene Therapy | Cell Biology
Book
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 7, pp. 1200 - 1208
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 88, pp. 48 - 59
Journal Article