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Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/2000, Volume 20, Issue 2, pp. 441 - 452
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
3'-END | TRANSPORT | TURNOVER | DEADENYLATION | MESSENGER-RNA | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | SACCHAROMYCES-CEREVISIAE | PRECURSORS | 5.8S RIBOSOMAL-RNA | CELL BIOLOGY | RNA Helicases - metabolism | RNA-Binding Proteins - genetics | Exoribonucleases - genetics | Saccharomyces cerevisiae - genetics | Genes - genetics | Multienzyme Complexes - metabolism | RNA, Messenger - metabolism | RNA, Small Nucleolar - metabolism | RNA, Small Nuclear - genetics | RNA Helicases - genetics | RNA, Fungal - genetics | Genes, Fungal - genetics | Genes, Fungal - physiology | DEAD-box RNA Helicases | Introns - genetics | Endoribonucleases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Fungal Proteins - genetics | Poly A - genetics | Mutation - genetics | RNA, Small Nucleolar - genetics | RNA, Fungal - metabolism | Phenotype | Poly A - metabolism | RNA Processing, Post-Transcriptional - genetics | Ribonuclease III | Saccharomyces cerevisiae Proteins | Saccharomyces cerevisiae - enzymology | Kinetics | RNA, Small Nuclear - metabolism | Transcription, Genetic - genetics | Exosome Multienzyme Ribonuclease Complex | Exoribonucleases - metabolism | RNA-Binding Proteins - metabolism | Fungal Proteins - metabolism | exosomes | rRNA 5.8S | RRP6 gene | MTR4 gene | exosome | snRNA | snoRNA | Gene Expression
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7660, pp. 617 - 621
.... The mobile U2 small nuclear ribonucleoprotein particle (snRNP) associates with U4/U6. U5 tri-snRNP through the U2/U6 helix II and an interface between U4/U6 di-snRNP... 
U4/U6.U5 TRI-SNRNP | COMPLEX | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | U2 SNRNP | CRYO-EM STRUCTURE | REQUIRES ATP | RNA Helicases - metabolism | Ribonucleoprotein, U2 Small Nuclear - chemistry | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoprotein, U2 Small Nuclear - metabolism | Base Sequence | Protein Domains | RNA Precursors - metabolism | Ribonucleoproteins, Small Nuclear - chemistry | Protein Stability | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | Introns - genetics | RNA Splice Sites - genetics | Models, Molecular | Nuclear Proteins - metabolism | RNA Precursors - genetics | Spliceosomes - ultrastructure | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Baking yeast | Ribonucleoproteins (small nuclear) | Molecular structure | mRNA | Ribonucleoproteins (U2 small nuclear) | Electron microscopy | Ribonucleic acid--RNA | snRNA | Proteins | DNA helicase | Transmission electron microscopy | Catalysis | Atomic structure
Journal Article
Blood, ISSN 0006-4971, 2012, Volume 121, Issue 6, pp. 1028 - 1038
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 520 - 533
.... One example is the trimeric human nuclear exosome targeting (NEXT) complex, which is composed of hMTR4... 
RNA exosome | PAXT connection | nuclear RNA decay | poly(A) tail | NEXT complex | COMPLEX | MESSENGER-RNA | CRYPTIC UNSTABLE TRANSCRIPTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR ARCHITECTURE | POLY(A)-BINDING PROTEIN | POLYMERASE | 3'-END MATURATION | QUALITY CONTROL | DEGRADATION | POLY(A) TAIL LENGTH | CELL BIOLOGY | RNA Helicases - metabolism | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | RNA, Messenger - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Helicases - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Nuclear Proteins - genetics | Poly(A)-Binding Protein I - genetics | Binding Sites | RNA-Binding Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Poly A - genetics | Transcription Factors - genetics | RNA Stability - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Poly A - metabolism | Carrier Proteins - metabolism | Cell Nucleus - genetics | Nuclear Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - antagonists & inhibitors | Protein Binding | HeLa Cells | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Zinc compounds | RNA | Molecular biology | Protein binding
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12655 - 12660
The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac... 
T lymphocytes | Pathology | RNA | HEK293 cells | Genes | Cell lines | Antibodies | Small nuclear RNA | Gene expression regulation | HIV 1 | 7SK SNRNA | TRANSCRIPTION FACTOR BCL11B | ELONGATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | POLYMERASE | HIV-1 TAT | MICROGLIAL CELLS | T-CELL LINEAGE | BROMODOMAIN PROTEIN BRD4 | RNA-Binding Proteins - genetics | Humans | Myosin Heavy Chains - genetics | Cardiomegaly - pathology | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Myosin Heavy Chains - metabolism | RNA, Small Nuclear - genetics | Tumor Suppressor Proteins - genetics | HEK293 Cells | Cardiac Myosins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Cyclin-Dependent Kinase 9 - genetics | Cardiac Myosins - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Cyclin-Dependent Kinase 9 - metabolism | Mice | RNA, Small Nuclear - metabolism | Cardiomegaly - genetics | RNA-Binding Proteins - metabolism | Cardiomegaly - metabolism | Physiological aspects | Transcription factors | Genetic aspects | Heart enlargement | Health aspects | Myosin | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2004, Volume 116, Issue 1, pp. 63 - 73
.... When overall pre-mRNA levels are increased by deletion of RRP6, a nuclear exosome component, MLP1 deletion augments leakage of only the intron-containing portion of mRNAs... 
SITE | PORE COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLING TRANSCRIPTION | EXPORT | COMPONENT | QUALITY-CONTROL | PROTEINS | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DELETION | CELL BIOLOGY | Exoribonucleases - genetics | Exoribonucleases - deficiency | RNA, Messenger - metabolism | Ribonucleoprotein, U5 Small Nuclear | Nuclear Pore Complex Proteins - genetics | Cell Nucleus - metabolism | Nuclear Proteins - deficiency | RNA Splicing - genetics | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Yeasts - metabolism | Introns - genetics | Nuclear Envelope - genetics | RNA Splice Sites - genetics | Nuclear Pore Complex Proteins - metabolism | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | Protein Transport - genetics | Nuclear Envelope - metabolism | Yeasts - genetics | Cell Nucleus - genetics | Saccharomyces cerevisiae Proteins - metabolism | Exosome Multienzyme Ribonuclease Complex | Yeasts | RNA Splice Sites | Nuclear Pore Complex Proteins | Exoribonucleases | Introns | RNA-Binding Proteins | Nuclear Envelope | Cellular Biology | Nuclear Proteins | Protein Transport | Life Sciences | RNA Splicing | Saccharomyces cerevisiae Proteins | Active Transport, Cell Nucleus | Mutation | Subcellular Processes | RNA, Messenger | Cell Nucleus
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 537, Issue 7619, pp. 197 - 201
.... The 5'-splice site is cleaved but remains close to the catalytic Mg2+ site in the U2/U6 small nuclear RNA (snRNA... 
U4/U6.U5 TRI-SNRNP | IN-VITRO | ELECTRON CRYOMICROSCOPY | ACTIVE-SITE | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | PRE-MESSENGER-RNA | CATALYTIC ACTIVATION | RNA Precursors - chemistry | RNA Helicases - metabolism | Spliceosomes - chemistry | RNA, Fungal - ultrastructure | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA Precursors - metabolism | RNA, Fungal - genetics | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Introns - genetics | RNA Splice Sites - genetics | RNA, Fungal - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Exons - genetics | Magnesium - metabolism | Nuclear Proteins - metabolism | Spliceosomes - ultrastructure | Esterification | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Base Pairing | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Structure | Brewer's yeast | Methods | RNA splicing | Proteins | Enzymes | Molecular structure | Microscopy | Catalysis | Ribonucleic acid--RNA | Binding sites
Journal Article
Journal Article