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Science, ISSN 0036-8075, 5/2001, Volume 292, Issue 5518, pp. 897 - 902
Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the... 
Messenger RNA | Hydrogen bonds | RNA | Antibiotics | Protein synthesis | Ribosomes | Crystals | Research Articles | Codons | Anticodon | Transfer RNA | P-SITE | ANGSTROM RESOLUTION | ELONGATION-FACTOR TU | ESCHERICHIA-COLI RIBOSOME | AMINOACYL-TRANSFER-RNA | PHENYLALANINE TRANSFER-RNA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | A-SITE | 70S RIBOSOME | DNA-REPLICATION | Codon - metabolism | Anticodon - metabolism | Protein Biosynthesis | Peptide Chain Elongation, Translational | RNA, Transfer, Phe - chemistry | Anticodon - chemistry | RNA, Transfer, Amino Acid-Specific - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Crystallography, X-Ray | Thermus thermophilus - ultrastructure | Guanosine Triphosphate - metabolism | RNA, Messenger - metabolism | Paromomycin - pharmacology | Thermodynamics | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | RNA, Bacterial - metabolism | RNA, Ribosomal, 16S - metabolism | RNA, Transfer, Phe - metabolism | Thermus thermophilus - chemistry | RNA, Transfer - metabolism | Ribosomes - chemistry | Models, Molecular | Anti-Bacterial Agents - metabolism | Peptide Elongation Factor Tu - metabolism | RNA, Transfer, Amino Acid-Specific - chemistry | RNA, Ribosomal, 16S - chemistry | Ribosomes - ultrastructure | Codon - chemistry | Base Pairing | Hydrogen Bonding | RNA, Bacterial - chemistry | RNA, Messenger - chemistry | Anti-Bacterial Agents - pharmacology | Paromomycin - metabolism | Protein research | Usage | Polypeptides | Amino acids | Research | Molecular biology | Statistics | Ribonucleic acid--RNA | Ribonucleic acid | ribosomal subunit 30S | paromomysin | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2006, Volume 313, Issue 5795, pp. 1935 - 1942
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and... 
Phosphates | Oxygen | Messenger RNA | RNA | Ribosomes | Haloarcula | Research Articles | Nucleotides | Anticodon | Transfer RNA | Metal ions | P-SITE | ANGSTROM RESOLUTION | ATOMIC-STRUCTURE | ESCHERICHIA-COLI RIBOSOME | BACTERIAL RIBOSOME | PHENYLALANINE TRANSFER-RNA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PEPTIDE-BOND FORMATION | 50S SUBUNITS | PROTEIN L27 | Ribosomal Proteins - chemistry | Protein Biosynthesis | RNA, Transfer, Phe - chemistry | Bacterial Proteins - chemistry | Ribosomes - metabolism | Crystallography, X-Ray | Thermus thermophilus - ultrastructure | RNA, Messenger - metabolism | Ribosomal Proteins - metabolism | Codon | Nucleic Acid Conformation | RNA, Transfer - chemistry | RNA, Bacterial - metabolism | RNA, Transfer, Phe - metabolism | Peptidyl Transferases - metabolism | Thermus thermophilus - chemistry | RNA, Transfer - metabolism | Peptidyl Transferases - chemistry | RNA, Transfer, Met - metabolism | Crystallization | Ribosomes - chemistry | Models, Molecular | Magnesium - metabolism | Ribosomes - ultrastructure | RNA, Transfer, Met - chemistry | RNA, Bacterial - chemistry | Bacterial Proteins - metabolism | Protein Conformation | RNA, Messenger - chemistry | Research | Structure | Ribosomal RNA | Analysis | Bacteria | Genetics | Biochemistry | Ribonucleic acid--RNA | Ribonucleic acid | Crystal structure | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2012, Volume 48, Issue 3, pp. 409 - 421
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the degradation of short-lived noncoding RNAs, and in the quality control of RNAs... 
II TRANSCRIPTS | RAPID TRANSFER-RNA | OXIDATIVE STRESS | MATURE TRANSFER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A) POLYMERASE | QUALITY-CONTROL | RIBOSOMAL-RNA | SACCHAROMYCES-CEREVISIAE | BIDIRECTIONAL PROMOTERS | NUCLEAR EXOSOME | CELL BIOLOGY | Introns - genetics | Oligonucleotide Array Sequence Analysis | RNA Processing, Post-Transcriptional | RNA, Transfer - metabolism | Saccharomyces cerevisiae - genetics | RNA, Ribosomal - metabolism | Substrate Specificity | RNA Precursors - genetics | Gene Expression Profiling | Saccharomyces cerevisiae Proteins - genetics | RNA, Ribosomal - genetics | RNA, Small Nucleolar - genetics | RNA, Fungal - metabolism | Saccharomyces cerevisiae - metabolism | Blotting, Northern | RNA, Small Nucleolar - metabolism | Saccharomyces cerevisiae Proteins - metabolism | RNA, Transfer - genetics | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Precursors - metabolism | RNA, Fungal - genetics | Mutation | Exosome Multienzyme Ribonuclease Complex - genetics | Analysis | Transfer RNA | Index Medicus | RNA Precursors | Introns | Quantitative Methods | Biochemistry, Molecular Biology | Genomics | Cellular Biology | RNA, Transfer | Bacteriology | Life Sciences | Microbiology and Parasitology | RNA, Ribosomal | RNA, Small Nucleolar | Saccharomyces cerevisiae Proteins | RNA, Fungal | Subcellular Processes | Exosome Multienzyme Ribonuclease Complex | Molecular biology | Saccharomyces cerevisiae
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 128 - 132
Folates enable the activation and transfer of one-carbon units for the biosynthesis of purines, thymidine and methionine(1-3). Antifolates are important... 
CHAIN | HYPERTROPHIC CARDIOMYOPATHY | SERINE HYDROXYMETHYLTRANSFERASE | METABOLISM | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | DEFECT | LACTIC-ACIDOSIS | MUTATIONS | IDENTIFICATION | ANTICODON WOBBLE NUCLEOTIDE | Mitochondria - enzymology | Electron Transport | Protein Biosynthesis | Humans | Ribosomes - metabolism | Sarcosine - metabolism | Multifunctional Enzymes - metabolism | Thymine Nucleotides - biosynthesis | Oxidative Phosphorylation - drug effects | Glycine Hydroxymethyltransferase - deficiency | HEK293 Cells | RNA, Transfer - genetics | Codon - genetics | RNA, Transfer - chemistry | Leucine - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Biocatalysis | RNA, Transfer - metabolism | HCT116 Cells | Mitochondria - metabolism | Mitochondria - drug effects | Glycine Hydroxymethyltransferase - metabolism | Guanosine - metabolism | Tetrahydrofolates - metabolism | Lysine - genetics | Carrier Proteins - metabolism | Methylation - drug effects | Folic Acid - metabolism | Aminohydrolases - metabolism | Folic Acid Antagonists - pharmacology | GTP-Binding Proteins - metabolism | Mitochondria | Physiological aspects | Genetic aspects | Methylation | Observations | Genetic translation | Folic acid | Transfer RNA | Phosphorylation | Inborn errors of metabolism | Peptides | Serine | Biosynthesis | Mitochondrial DNA | Thymidine | Catalytic activity | Leucine | Cytosol | Experiments | Anticancer properties | Proteins | Purines | Antitumor agents | Metabolites | Lymphocytes | Vitamin B | Catalysis | Enzymes | Translation | tRNA Ala | tRNA | Methionine | Metabolism | Carbon | Immunosuppression | Oxidative phosphorylation | Lysine | Proteomics | Electron transport | Respiration | Codons | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 441 - 444
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7606, pp. 277 - 280
In order to survive, bacteria continually sense, and respond to, environmental fluctuations. Stringent control represents a key bacterial stress response to... 
EF-TU | ELECTRON CRYOMICROSCOPY | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | CRYO-EM | TRANSFER-RNA | RIBONUCLEIC ACID SYNTHESIS | PROTEIN-SYNTHESIS | RELA | GUANOSINE TETRAPHOSPHATE | Guanosine Tetraphosphate - chemistry | Phosphorylation | Protein Biosynthesis | RNA, Transfer, Amino Acyl - chemistry | Stress, Physiological | Ribosomes - metabolism | Escherichia coli Proteins - ultrastructure | RNA, Transfer - ultrastructure | Guanosine Tetraphosphate - metabolism | Escherichia coli - pathogenicity | Escherichia coli - metabolism | RNA, Transfer, Amino Acyl - metabolism | GTP Pyrophosphokinase - metabolism | RNA, Transfer - genetics | Escherichia coli Proteins - antagonists & inhibitors | GTP Pyrophosphokinase - ultrastructure | RNA, Transfer - chemistry | Binding Sites | Second Messenger Systems | Protein Structure, Tertiary | GTP Pyrophosphokinase - antagonists & inhibitors | RNA, Transfer - metabolism | Ribosomes - chemistry | Models, Molecular | Escherichia coli Proteins - metabolism | RNA, Transfer, Amino Acyl - genetics | Amino Acids - deficiency | Cryoelectron Microscopy | Ribosomes - ultrastructure | Metabolic Networks and Pathways | Escherichia coli - genetics | Adenosine - metabolism | GTP Pyrophosphokinase - genetics | Protein Conformation | Escherichia coli Proteins - chemistry | Gene Expression Regulation, Bacterial | Escherichia coli - ultrastructure | Microbiological research | Transcription factors | Escherichia coli | Ribosomes | Research | Virulence (Microbiology) | Transfer RNA | E coli | Antibiotics | Ribonucleic acid--RNA | Crystal structure | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6008, pp. 1203 - 1209
Crystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the... 
Proteins | Yeasts | RESEARCH ARTICLE | Messenger RNA | RNA | Prokaryotes | Ribosomes | Crystals | Eukaryotic cells | Transfer RNA | Crystal structure | E-SITE | ANGSTROM RESOLUTION | TRANSLOCATION | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOVEMENT | TRANSLATION INITIATION | TRANSFER-RNA | 70S RIBOSOME | 80S RIBOSOME | SUBUNIT | Ribosomal Proteins - analysis | Ribosomal Proteins - chemistry | RNA, Fungal - analysis | Ribosome Subunits, Large, Eukaryotic - ultrastructure | Protein Biosynthesis | Ribosome Subunits, Small, Eukaryotic - chemistry | Saccharomyces cerevisiae - genetics | RNA, Messenger - analysis | Ribosomes - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Saccharomyces cerevisiae - ultrastructure | RNA, Messenger - metabolism | Ribosomal Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Nucleic Acid Conformation | RNA, Transfer - chemistry | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | RNA, Fungal - chemistry | RNA, Ribosomal - chemistry | Crystallization | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | Ribosome Subunits, Small, Eukaryotic - ultrastructure | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Ribosomes - ultrastructure | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | RNA, Ribosomal - analysis | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae Proteins - analysis | Saccharomyces cerevisiae Proteins - chemistry | Composition | Eukaryotes | Physiological aspects | Protein biosynthesis | Research | Structure | Conformation | Networks | Protein synthesis | Bacteria | Mathematical models | Ratcheting | Translations | Index Medicus
Journal Article