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Journal Article
Molecular cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
... (DNAPKc, Ku70, and Ku80) and paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATRIN3... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2014, Volume 10, Issue 4, pp. e1003989 - e1003989
...) gene induction and protein secretion in response to MVA infection. We report that MVA infection elicits the production of type I IFN in murine conventional dendritic cells (cDCs... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Index Medicus | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 10/2009, Volume 183, Issue 8, pp. 4879 - 4886
...) in the receptor's cytoplasmic region. The adaptor protein downstream of tyrosine kinase 2 (Dok2) bound directly to the phosphorylated NPLY motif with a 10-fold higher affinity... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Phosphoproteins - immunology | Antigens, CD - immunology | p120 GTPase Activating Protein - metabolism | Humans | Glycoproteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Matrilin Proteins | Signal Transduction - immunology | ras GTPase-Activating Proteins - genetics | Interleukin-4 - pharmacology | RNA, Small Interfering - immunology | Myeloid Cells - immunology | Adaptor Proteins, Signal Transducing - immunology | Antigens, Surface - metabolism | Myeloid Cells - drug effects | Interleukin-8 - metabolism | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | ras GTPase-Activating Proteins - metabolism | DNA-Binding Proteins - immunology | Cartilage Oligomeric Matrix Protein | RNA-Binding Proteins - immunology | Antigens, Surface - genetics | Rats | Receptors, Cell Surface - metabolism | Phosphoproteins - genetics | Receptors, Cell Surface - immunology | Glycoproteins - immunology | Macrophages - metabolism | Animals | Extracellular Matrix Proteins - immunology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Mice | ras GTPase-Activating Proteins - immunology | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-8 - immunology | Antigens, Surface - immunology | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Cell (Cambridge), ISSN 0092-8674, 10/2018, Volume 175, Issue 2, pp. 488 - 501.e22
.... However, synthesis of HIV DNA during infection is not sufficient for immune activation. The capsid protein, which associates with viral DNA, has a pivotal role in enabling cGAS-mediated immune activation... 
HIV-1 | macrophages | HIV-2 | dendritic cells | innate immunity | NONO | capsid | cGAS | STING | innate immune sensors | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dendritic Cells - immunology | Humans | Octamer Transcription Factors - immunology | Nucleotidyltransferases - physiology | HIV Infections - immunology | Signal Transduction - immunology | Capsid Proteins - physiology | Cell Nucleus - metabolism | Octamer Transcription Factors - physiology | Nuclear Matrix-Associated Proteins - physiology | Capsid Proteins - immunology | HIV-2 - genetics | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Capsid - metabolism | Macrophages - immunology | RNA-Binding Proteins - physiology | Capsid Proteins - metabolism | Nuclear Matrix-Associated Proteins - immunology | RNA-Binding Proteins - immunology | Nuclear Matrix-Associated Proteins - metabolism | HIV-1 - genetics | Host-Pathogen Interactions | DNA, Viral - immunology | Immunity, Innate - immunology | HIV-1 - immunology | HIV-2 - immunology | DNA, Viral - genetics | RNA-Binding Proteins - metabolism | Antiviral agents | Viral proteins | Dendritic cells | HIV testing | Sensors | HIV (Viruses) | Macrophages | Health aspects | Cyclic guanylic acid | Protein binding | Life Sciences | Genetics | Human genetics
Journal Article
Nature immunology, ISSN 1529-2908, 08/2010, Volume 11, Issue 8, pp. 717 - 724
Journal Article
Nature immunology, ISSN 1529-2916, 11/2009, Volume 11, Issue 2, pp. 141 - 147
Journal Article
Cancer science, ISSN 1349-7006, 11/2007, Volume 98, Issue 11, pp. 1803 - 1808
...) to the TTK protein kinase (TTK), lymphocyte antigen 6 complex locus K (LY6K) and insulin-like growth factor (IGF... 
Life Sciences & Biomedicine | Oncology | Science & Technology | RNA-Binding Proteins - genetics | Immunotherapy - methods | Protein-Tyrosine Kinases - metabolism | Humans | Antigens, Ly - genetics | Peptides - genetics | Lung Neoplasms - pathology | Protein-Tyrosine Kinases - immunology | Esophageal Neoplasms - pathology | Cell Cycle Proteins - immunology | Protein-Tyrosine Kinases - genetics | Peptides - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Antigens, Ly - metabolism | Cytotoxicity Tests, Immunologic - methods | Epitopes, T-Lymphocyte - immunology | Esophageal Neoplasms - therapy | Protein-Serine-Threonine Kinases - metabolism | T-Lymphocytes, Cytotoxic - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | Cell Line | GPI-Linked Proteins - immunology | HLA-A24 Antigen - immunology | Antigens, Neoplasm - immunology | Peptides - immunology | RNA-Binding Proteins - immunology | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Lung Neoplasms - therapy | Esophageal Neoplasms - immunology | GPI-Linked Proteins - metabolism | Cancer Vaccines - immunology | Lung Neoplasms - immunology | Antigens, Ly - immunology | T-Lymphocytes, Cytotoxic - metabolism | Cell Line, Tumor | Protein-Serine-Threonine Kinases - immunology | Biomarkers, Tumor - genetics | Cytotoxicity, Immunologic - immunology | Biomarkers, Tumor - immunology | T-Lymphocytes, Cytotoxic - cytology | Epitopes, T-Lymphocyte - metabolism | RNA-Binding Proteins - metabolism | GPI-Linked Proteins - genetics | Care and treatment | Peptides | Lung cancer | MHC antibodies | HLA histocompatibility antigens | Histocompatibility antigens | Immunotherapy | Genetic research | Genetic aspects | Drug therapy | Esophageal cancer | Cancer | Antigenic determinants | Index Medicus
Journal Article