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life sciences & biomedicine (39) 39
science & technology (39) 39
crispr (27) 27
biochemistry & molecular biology (20) 20
cas9 (20) 20
genome editing (20) 20
cell biology (16) 16
humans (13) 13
rna (13) 13
crispr-cas systems (12) 12
genetic engineering (12) 12
genomes (11) 11
genomics (11) 11
crispr/cas9 (10) 10
rna, guide - genetics (10) 10
base sequence (9) 9
endonucleases - genetics (8) 8
gene editing (8) 8
gene targeting (8) 8
clustered regularly interspaced short palindromic repeats - genetics (7) 7
endonucleases - metabolism (7) 7
enzymes (7) 7
plant sciences (7) 7
proteins (7) 7
rna, guide - metabolism (7) 7
rna-guided endonucleases (7) 7
analysis (6) 6
clustered regularly interspaced short palindromic repeats (6) 6
deoxyribonucleic acid--dna (6) 6
gene editing - methods (6) 6
genome (6) 6
genome engineering (6) 6
molecular sequence data (6) 6
mutation (6) 6
protein binding (6) 6
review (6) 6
rna-guided endonuclease (6) 6
animals (5) 5
biochemical research methods (5) 5
biotechnology (5) 5
cpf1 (5) 5
crispr-associated proteins - genetics (5) 5
crispr-associated proteins - metabolism (5) 5
crispr-cas (5) 5
gene expression (5) 5
homologous recombination (5) 5
mutagenesis (5) 5
nucleases (5) 5
research (5) 5
rna-guided dna cleavage (5) 5
cell line (4) 4
crispr-cas systems - genetics (4) 4
genom (4) 4
mice (4) 4
plant science (4) 4
plasmids (4) 4
ribonucleic acid--rna (4) 4
rna-guided nucleases (4) 4
transcription activator-like effector nucleases (4) 4
bacterial proteins - chemistry (3) 3
bacterial proteins - genetics (3) 3
bacterial proteins - metabolism (3) 3
biology (3) 3
biotechnology & applied microbiology (3) 3
c2c2 (3) 3
crispr/cas (3) 3
dna (3) 3
dna - genetics (3) 3
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endonuclease (3) 3
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gene (3) 3
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guide rna (3) 3
methods (3) 3
microbiology (3) 3
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nuclease (3) 3
rgens (3) 3
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rna processing, post-transcriptional (3) 3
rna-guided (3) 3
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sgrna (3) 3
talens (3) 3
transcription (3) 3
zfns (3) 3
zinc-finger nucleases (3) 3
amino acid sequence (2) 2
anopheles (2) 2
bacteria (2) 2
bacteria - genetics (2) 2
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1. Full Text Decrosslinking enables visualization of RNA-guided endonuclease–in situ labeling signals for DNA sequences in plant tissues
by Nagaki, K and Yamaji, N
Journal of experimental botany, ISSN 0022-0957, 03/2020, Volume 71, Issue 6, pp. 1792 - 1800
Immunohistochemistry | Centromere | CRISPR/Cas9 | In situ DNA visualization | Epigenetic modifications | RNA-guided endonuclease–in situ labeling (RGEN-ISL) | Telomere | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Index Medicus | CRISPR | Research Papers | SCI01210 | telomere | epigenetic modifications | in situ DNA visualization | Cas9 | immunohistochemistry | AcademicSubjects
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2. Full Text RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?
by Gasiunas, Giedrius and Siksnys, Virginijus
Trends in microbiology (Regular ed.), ISSN 0966-842X, 2013, Volume 21, Issue 11, pp. 562 - 567
Internal Medicine | gene targeting | RNA-guided DNA cleavage | molecular tools | clustered regularly interspaced short palindromic repeat (CRISPR) | Molecular tools | Gene targeting | Clustered regularly interspaced short palindromic repeat (CRISPR) | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Genetic Engineering - methods | Recombinant Proteins - metabolism | Deoxyribonuclease I - metabolism | Recombination, Genetic | Clustered Regularly Interspaced Short Palindromic Repeats | Recombinant Proteins - genetics | DNA - metabolism | Molecular Biology - methods | RNA - metabolism | Nucleases | RNA | Genomics | DNA | Index Medicus
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3. Full Text Endonucleases: new tools to edit the mouse genome
by Wijshake, Tobias and Baker, Darren J and van de Sluis, Bart
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 10/2014, Volume 1842, Issue 10, pp. 1942 - 1950
Genome editing | ZFN | Mouse | CRISPR/Cas | TALEN | Endonucleases | CRISPR-CAS SYSTEMS | GENE KNOCKOUT | CD4(+) T-CELLS | EMBRYO MICROINJECTION | ZINC-FINGER NUCLEASES | DNA-BINDING SPECIFICITY | PLURIPOTENT STEM-CELLS | SITE-SPECIFIC RECOMBINATION | EFFICIENT TARGETED MUTAGENESIS | RNA-GUIDED ENDONUCLEASES | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animal genetics | RNA | Genomics | Genetically modified organisms | Genetic research | Mice | Zinc finger proteins | Embryonic stem cells | Protein binding
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4. Full Text The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
by Murugan, Karthik and Babu, Kesavan and Sundaresan, Ramya and Rajan, Rakhi and Sashital, Dipali G
Molecular cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 15 - 25
C2c2 | genome editing | C2c1 | CRISPR-Cas | Cpf1 | RNA-guided DNA cleavage | Cas13 | Cas9 | Cas12 | RNA-guided RNA cleavage | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Endonucleases - genetics | Bacteriophages - growth & development | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Endonucleases - metabolism | Bacteria - genetics | Endonucleases - chemistry | Bacteria - immunology | Endonucleases - classification | Genetic Engineering | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Protein Domains | Bacterial Proteins - metabolism | Protein Conformation | Transcription, Genetic | Bacterial Proteins - classification | Gene Editing - methods | Genome | Bacteria - virology | Genetic engineering | Genetically modified organisms | Phylogeny | Nucleases | Transposons | RNA | Analysis | Genomics | Index Medicus
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5. Full Text Creation of targeted inversion mutations in plants using an RNA-guided endonuclease
by Zhang, Congsheng and Liu, Changlin and Weng, Jianfeng and Cheng, Beijiu and Liu, Fang and Li, Xinhai and Xie, Chuanxiao
The Crop journal, ISSN 2214-5141, 02/2017, Volume 5, Issue 1, pp. 83 - 88
RNA-guided endonuclease | Targeted inversion | CRISPR/Cas9 | Genetic improvement | Agriculture | Life Sciences & Biomedicine | Plant Sciences | Agronomy | Science & Technology
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6. Full Text A simple test for the cleavage activity of customized endonucleases in plants
by Budhagatapalli, Nagaveni and Schedel, Sindy and Gurushidze, Maia and Pencs, Stefanie and Hiekel, Stefan and Rutten, Twan and Kusch, Stefan and Morbitzer, Robert and Lahaye, Thomas and Panstruga, Ralph and Kumlehn, Jochen and Hensel, Goetz
Plant methods, ISSN 1746-4811, 03/2016, Volume 12, Issue 1, pp. 18 - 18
Transcription activator-like effector nucleases | RNA-guided endonucleases | Site-directed mutagenesis | Biolistic gene transfer | Transient expression | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Biochemical Research Methods | Science & Technology | Plant proteins | Enzymes | Botanical research | Genetic research | Hydrolases | Regulation | Research | Properties
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7. Full Text In vitro enzymology of cas9
by Anders, Carolin and Jinek, Martin
Methods in enzymology, ISSN 0076-6879, 2014, Volume 546, Issue C, pp. 1 - 20
CRISPR | Gene targeting | Protein-RNA complex | Biochemical assay | Genome editing | RNA guided | Endonuclease | crRNA tracrRNA | Recombinant Proteins - metabolism | Transformation, Genetic | Cell Line | Endonucleases - genetics | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | RNA, Guide - metabolism | Transcriptome | Molecular Sequence Data | Endonucleases - isolation & purification | Recombinant Proteins - genetics | Streptococcus pyogenes - metabolism | Endonucleases - metabolism | Recombinant Proteins - isolation & purification | Streptococcus pyogenes - genetics | Base Sequence | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | Cloning, Molecular - methods | Transcription, Genetic | DNA Cleavage | CRISPR-Associated Proteins - isolation & purification | Index Medicus
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8. Full Text Quantifying on- and off-target genome editing
by Hendel, Ayal and Fine, Eli J and Bao, Gang and Porteus, Matthew H
Trends in biotechnology (Regular ed.), ISSN 0167-7799, 2014, Volume 33, Issue 2, pp. 132 - 140
Internal Medicine | RNA-guided endonucleases | homologous recombination | CRISPR/Cas9 | TALENs | nonhomologous end-joining | gene targeting | ZFNs | gene editing | Gene targeting | Gene editing | Homologous recombination | Nonhomologous end-joining | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic Engineering - methods | Endonucleases - genetics | Gene Expression | Mutagenesis, Site-Directed | Humans | Homologous Recombination | Green Fluorescent Proteins - genetics | Genetic Loci | DNA End-Joining Repair | Luminescent Proteins - genetics | Zinc Fingers - genetics | Genome, Human | Genes, Reporter | Genetic Therapy - methods | Genomics | Scholarships & fellowships | Laboratories | Cell cycle | Editing | Genomes | Mutation | Molecular biology | DNA repair | Deoxyribonucleic acid--DNA | Index Medicus | CRISPR | RGENs | non-homologous end-joining | RNA guided endonucleases | Cas9
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9. Full Text Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
by Liu, Liang and Li, Xueyan and Wang, Jiuyu and Wang, Min and Chen, Peng and Yin, Maolu and Li, Jiazhi and Sheng, Gang and Wang, Yanli
Cell (Cambridge), ISSN 0092-8674, 01/2017, Volume 168, Issue 1-2, pp. 121 - 134.e12
endonuclease | CRISPR-Cas | C2c2 | RNA-guided RNA cleavage | precursor crRNA | HEPN domain | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Catalytic Domain | RNA Processing, Post-Transcriptional | Ribonucleases - chemistry | Leptotrichia - enzymology | Models, Molecular | Sequence Alignment | Mutagenesis | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Leptotrichia - chemistry | RNA, Untranslated - chemistry | Leptotrichia - metabolism | Leptotrichia - classification | RNA | Ribonuclease | Nucleases | Structure | Crystals | Index Medicus
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