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Journal Article
Journal Article
Cell, ISSN 0092-8674, 12/2018, Volume 175, Issue 7, pp. 1856 - 1871.e21
Cas12a, also known as Cpf1, is a type V-A CRISPR-Cas RNA-guided endonuclease that is used for genome editing based on its ability to generate specific dsDNA... 
CRISPR-Cas | single-molecule FRET | genome editing | protein-RNA-DNA complex | cryo-EM | CYTOCHROME-P450 OXIDOREDUCTASE | COMPLEX | STATES | SINGLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | RNA-GUIDED ENDONUCLEASE | CRYO-EM | MICROSCOPY | CLEAVAGE | CELL BIOLOGY | Thermodynamics | Enzymes | Nucleases | RNA | Analysis | Genomics | Catalysis
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 1, pp. 117 - 127.e5
Journal Article
Antiviral Research, ISSN 0166-3542, 02/2016, Volume 126, pp. 90 - 98
Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One potential approach to cure persistent viral infections is via... 
Resistance | Reverse transcriptase | Zinc finger nuclease | Endonuclease | HEPATITIS-B-VIRUS | HUMAN-PAPILLOMAVIRUS | DRUG-RESISTANCE | HUMAN T-CELLS | IN-VITRO | VIROLOGY | CRISPR/CAS9 SYSTEM | CERVICAL-CANCER CELLS | RNA-GUIDED ENDONUCLEASE | PHARMACOLOGY & PHARMACY | PROVIRAL DNA | ZINC-FINGER-NUCLEASES | Anti-HIV Agents - pharmacology | Phosphoproteins - pharmacology | Humans | Drug Resistance, Viral | HIV Protease - genetics | Molecular Sequence Data | Reverse Transcriptase Inhibitors - pharmacology | HIV Reverse Transcriptase - genetics | Exodeoxyribonucleases - pharmacology | Endonucleases - metabolism | Phosphoproteins - metabolism | Gene Products, pol - genetics | Base Sequence | HEK293 Cells | Cell Line | Gene Products, pol - metabolism | Virus Replication - drug effects | Zinc Fingers | Transduction, Genetic | HIV-1 - drug effects | HIV Infections - genetics | HIV Infections - virology | HIV-1 - genetics | HIV Reverse Transcriptase - metabolism | Exodeoxyribonucleases - metabolism | HIV Infections - therapy | HIV Infections - drug therapy | Mutation | DNA, Viral - genetics | HIV Protease - metabolism | Antiviral agents | Nucleases | Genomics | Mortality | T cells | HIV (Viruses) | Virus diseases | Proteases | HIV testing | DNA polymerases | Zinc finger proteins | Drug therapy | Health aspects | endonuclease | zinc finger nuclease | reverse transcriptase | resistance
Journal Article