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1. Full Text Target RNA—Directed Trimming and Tailing of Small Silencing RNAs
by Stefan L. Ameres and Michael D. Horwich and Jui-Hung Hung and Jia Xu and Megha Ghildiyal and Zhiping Weng and Phillip D. Zamore
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1534 - 1539
In Drosophila, microRNAs (miRNAs) typically guide Argonaute1 to repress messenger RNA (mRNA), whereas small interfering RNAs (siRNAs) guide Argonaute2 to... 
MicroRNA | Messenger RNA | RNA | RESEARCH ARTICLES | Drosophila | Cell lines | Small interfering RNA | HeLa cells | Nucleotides | Tailings | Renovations | ARGONAUTE2 PAZ DOMAIN | ENDOGENOUS SIRNAS | SOMATIC-CELLS | DISTINCT MECHANISMS | MESSENGER-RNA | RECOGNITION | DROSOPHILA-MELANOGASTER | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | 3' TERMINI | PIWI-INTERACTING RNAS | RNA, Small Interfering - genetics | Drosophila melanogaster - embryology | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | RNA, Small Interfering - chemistry | Eukaryotic Initiation Factors - metabolism | Cell Line | RNA, Messenger - genetics | RNA Caps | RNA, Complementary | RNA Stability | Animals | Base Pairing | Models, Biological | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | RNA, Messenger - chemistry | MicroRNAs - genetics | Drosophila Proteins - genetics | Methylation | MicroRNAs - chemistry | RNA, Small Interfering - metabolism | Gene targeting | Research | Genetic regulation | Enzymes | Insects | Ribonucleic acid--RNA | Gene expression | Molecular biology
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2. Full Text Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing
by Gregory, Richard I and Chendrimada, Thimmaiah P and Cooch, Neil and Shiekhattar, Ramin
Cell, ISSN 0092-8674, 2005, Volume 123, Issue 4, pp. 631 - 640
RNA interference is implemented through the action of the RNA-induced silencing complex (RISC). Although Argonaute2 has been identified as the catalytic center... 
HUMAN DICER | PAZ DOMAIN | DOUBLE-STRANDED-RNA | RNAI ENZYME COMPLEX | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROPROCESSOR COMPLEX | C-ELEGANS | DISTINCT ROLES | MAMMALIAN-CELLS | CELL BIOLOGY | Cell Line | RNA, Small Interfering - genetics | Diphosphates - metabolism | Ribonuclease III - metabolism | Humans | MicroRNAs - metabolism | RNA Precursors - genetics | Eukaryotic Initiation Factor-2 | Adenosine Triphosphate - analogs & derivatives | Peptide Initiation Factors - metabolism | Phosphates - metabolism | RNA Interference | Adenosine Triphosphate - metabolism | Base Sequence | RNA, Double-Stranded - genetics | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | RNA Precursors - metabolism | MicroRNAs - genetics | Models, Genetic | RNA, Double-Stranded - metabolism | Catalysis | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Gene silencing | Research | Genetic engineering | Central processing units | Polypeptides | RNA | Microprocessors | Protein binding
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3. Full Text Silencing by small RNAs is linked to endosomal trafficking
by Kim, Kevin and Lee, Young Sik and Carthew, Richard W and Lim, Do Hwan and Cho, Ik Sang and Nakahara, Kenji and Andress, Arlise P and Preall, Jonathan B and Bellare, Priya and Pressman, Sigal and White, Jamie L and Li, Xin and Cassidy, Justin J and Lubell, Kim and Sontheimer, Erik J
Nature Cell Biology, ISSN 1465-7392, 09/2009, Volume 11, Issue 9, pp. 1150 - 1156
Small RNAs direct RNA-induced silencing complexes (RISCs) to regulate stability and translation of mRNAs. RISCs associated with target mRNAs often accumulate... 
MESSENGER-RNAS | PROTEIN | BIOGENESIS | ORGANELLES | UBIQUITIN | COMPLEXES | DEFICIENT | MECHANISMS | MICRORNAS | DROSOPHILA | CELL BIOLOGY | Humans | Drosophila melanogaster - cytology | Gene Silencing | MicroRNAs - metabolism | Drosophila Proteins - metabolism | Endosomes - metabolism | Drosophila melanogaster - metabolism | Ubiquitination | Animals | Biological Transport | RNA-Induced Silencing Complex - metabolism | HeLa Cells | RNA, Small Interfering - metabolism | Gene silencing | Messenger RNA | Drosophila | Physiological aspects | Genetic aspects | Research | Health aspects
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4. Full Text In Vitro Assembly of Plant RNA-Induced Silencing Complexes Facilitated by Molecular Chaperone HSP90
by Iki, Taichiro and Yoshikawa, Manabu and Nishikiori, Masaki and Jaudal, Mauren C and Matsumoto-Yokoyama, Eiko and Mitsuhara, Ichiro and Meshi, Tetsuo and Ishikawa, Masayuki
Molecular Cell, ISSN 1097-2765, 07/2010, Volume 39, Issue 2, pp. 282 - 291
RNA-induced silencing complexes (RISCs) play central roles in posttranscriptional gene silencing. In plants, the mechanism of RISC assembly has remained... 
RNA | PROTEINS | Proteins | REPLICATION | ARGONAUTE COMPLEXES | AGO1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | R2D2 | INTERFERENCE | MIRNAS | SIRNA | CLEAVAGE | STRAND | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Induced Silencing Complex - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Multiprotein Complexes - genetics | RNA, Plant - metabolism | Protoplasts - cytology | Multiprotein Complexes - metabolism | Protoplasts - metabolism | Base Sequence | HSP90 Heat-Shock Proteins - genetics | Plant Proteins - metabolism | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Tobacco - metabolism | RNA, Plant - genetics | Tobacco - cytology | Plant Proteins - genetics | Cell-Free System - metabolism | Tobacco - genetics | RNA-Induced Silencing Complex - metabolism | HSP90 Heat-Shock Proteins - metabolism | MicroRNAs - genetics | Gene Silencing - physiology | RNA, Small Interfering - metabolism | Hydrolysis | Heat shock proteins | Ribonuclease | Hsp90 protein | Post-transcription | Translation | Cell-free system | Protoplasts | siRNA | Chaperones | RNA-induced silencing complex | Plant extracts | Gene silencing | Tobacco | miRNA | ATP
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5. Full Text Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
by Wang, Yanli and Juranek, Stefan and Li, Haitao and Sheng, Gang and Wardle, Greg S and Tuschl, Thomas and Patel, Dinshaw J
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7265, pp. 754 - 761
The slicer activity of the RNA-induced silencing complex resides within its Argonaute (Ago) component, in which the PIWI domain provides the catalytic residues... 
PAZ DOMAIN | RECOGNITION | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | DNA | MULTIDISCIPLINARY SCIENCES | PIWI PROTEIN | HUMAN RISC | ARGONAUTE | MESSENGER | SLICER ACTIVITY | Thermus thermophilus - enzymology | Phosphorylation | Biocatalysis | RNA-Induced Silencing Complex - genetics | Catalytic Domain - genetics | Gene Silencing | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Magnesium - metabolism | Structure-Activity Relationship | DNA - metabolism | RNA - chemistry | RNA - genetics | DNA - genetics | Thermus thermophilus - genetics | DNA - chemistry | Base Pairing | Cations, Divalent - metabolism | RNA-Induced Silencing Complex - metabolism | RNA-Induced Silencing Complex - chemistry | RNA - metabolism | Gene silencing | Nucleation | Research | RNA | Enzymes | Biochemistry | E coli | Ribonucleic acid--RNA
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6. Full Text MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
by Pasquinelli, Amy E
Nature Reviews Genetics, ISSN 1471-0056, 04/2012, Volume 13, Issue 4, pp. 271 - 282
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways. These small non-coding RNAs bind to target sequences in mRNAs, typically... 
RNA-Binding Proteins - genetics | RNA-Induced Silencing Complex - genetics | Gene Expression Regulation | RNA-Induced Silencing Complex - metabolism | MicroRNAs - physiology | RNA Stability | RNA, Messenger - metabolism | Binding Sites | RNA-Binding Proteins - metabolism | Physiological aspects | MicroRNA | Research | Gene expression
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7. Full Text Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
by Wang, Yanli and Juranek, Stefan and Li, Haitao and Sheng, Gang and Tuschl, Thomas and Patel, Dinshaw J
Nature, ISSN 0028-0836, 12/2008, Volume 456, Issue 7224, pp. 921 - 926
Here we report on a 3.0 angstrom crystal structure of a ternary complex of wild- type Thermus thermophilus argonaute bound to a 5 '- phosphorylated 21-... 
PAZ DOMAIN | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PIWI PROTEIN | HUMAN RISC | SIRNAS | INTERFERENCE | ENZYME COMPLEX | CLEAVAGE | SLICER ACTIVITY | Phosphorylation | Thermus thermophilus - chemistry | RNA-Induced Silencing Complex - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Base Pair Mismatch | DNA - metabolism | RNA - chemistry | RNA - genetics | DNA - genetics | DNA - chemistry | Base Pairing | RNA Interference | Base Sequence | RNA-Induced Silencing Complex - metabolism | Bacterial Proteins - metabolism | Protein Conformation | RNA-Induced Silencing Complex - chemistry | Methylation | RNA - metabolism | Proteins | Gene silencing | Genetic aspects | Research | Chemical properties | Identification and classification | Target recognition | E coli | Ribonucleic acid--RNA | Crystal structure
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8. Full Text MicroRNA silencing through RISC recruitment of eIF6
by Chendrimada, Thimmaiah P and Finn, Kenneth J and Ji, Xinjun and Baillat, David and Gregory, Richard I and Liebhaber, Stephen A and Pasquinelli, Amy E and Shiekhattar, Ramin
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7146, pp. 823 - 828
MicroRNAs ( miRNAs) are a class of small RNAs that act post-transcriptionally to regulate messenger RNA stability and translation. To elucidate how miRNAs... 
MESSENGER-RNA DEGRADATION | CAENORHABDITIS-ELEGANS | PROTEIN | GENE | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC INITIATION FACTOR-6 | TRANSLATION INITIATION | C-ELEGANS | ASSOCIATION | LIN-4 RNA | Eukaryotic Initiation Factors - metabolism | Cell Line | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | Humans | RNA, Messenger - genetics | Gene Silencing | Caenorhabditis elegans Proteins - metabolism | Repressor Proteins - genetics | MicroRNAs - metabolism | RNA, Messenger - metabolism | Multiprotein Complexes - metabolism | Multiprotein Complexes - chemistry | Animals | RNA Interference | RNA, Helminth - metabolism | RNA-Induced Silencing Complex - metabolism | MicroRNAs - genetics | Nuclear Proteins - genetics | Caenorhabditis elegans Proteins - genetics | RNA, Helminth - genetics | RNA-Binding Proteins - metabolism | Evaluation | Usage | Cell research | RNA | Western immunoblotting | Cellular control mechanisms | Research | Gene expression | Proteins | Biochemistry | Molecular biology | Ribonucleic acid--RNA | Ribonucleic acid
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9. Full Text Sorting of Drosophila Small Silencing RNAs
by Tomari, Yukihide and Du, Tingting and Zamore, Phillip D
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 2, pp. 299 - 308
In , small interfering RNAs (siRNAs), which direct RNA interference through the Argonaute protein Ago2, are produced by a biogenesis pathway distinct from... 
PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | PASSENGER-STRAND | MICRORNA TARGETS | INTERFERENCE | DICER-2 | ENZYME COMPLEX | DISTINCT ROLES | SIRNA | CLEAVAGE | MELANOGASTER | CELL BIOLOGY | RNA Helicases - metabolism | RNA, Small Interfering - genetics | RNA Transport | Molecular Sequence Data | MicroRNAs - metabolism | Base Pair Mismatch | Drosophila Proteins - metabolism | Drosophila melanogaster - metabolism | RNA, Small Interfering - chemistry | Animals | Ribonuclease III | Base Sequence | RNA, Double-Stranded - genetics | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Eukaryotic Initiation Factors | RNA Precursors - metabolism | MicroRNAs - genetics | RNA, Double-Stranded - metabolism | Dimerization | MicroRNAs - chemistry | RNA, Double-Stranded - chemistry | RNA, Small Interfering - metabolism | Drosophila
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10. Full Text The role of PACT in the RNA silencing pathway
by Kim, Young-Kook and Suh, Mi Ra and Lee, Yoontae and Hur, Inha and Kim, V Narry and Park, Seong-Yeon
The EMBO Journal, ISSN 0261-4189, 02/2006, Volume 25, Issue 3, pp. 522 - 532
Small RNA‐mediated gene silencing (RNA silencing) has emerged as a major regulatory pathway in eukaryotes. Identification of the key factors involved in this... 
microRNA | RNAi | siRNA | Dicer | PACT | ARGONAUTE2 PAZ DOMAIN | CRYSTAL-STRUCTURE | MICRORNA BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | DEPENDENT PROTEIN-KINASE | NUCLEAR EXPORT | MICROPROCESSOR COMPLEX | HUMAN RISC | CELL BIOLOGY | STRUCTURAL BASIS | C-ELEGANS | Cell Line | RNA-Binding Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Signal Transduction | Humans | RNA-Induced Silencing Complex - genetics | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein Structure, Tertiary - genetics | Eukaryotic Initiation Factor-2 | Peptide Initiation Factors - metabolism | Peptide Initiation Factors - genetics | RNA Interference | RNA, Double-Stranded - genetics | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Protein Binding | MicroRNAs - genetics | RNA, Double-Stranded - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Nuclear Receptor Coactivators | RNA-Binding Proteins - metabolism | Protein Structure, Tertiary - physiology
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11. Full Text Biochemical Specialization within Arabidopsis RNA Silencing Pathways
by Qi, Yijun and Denli, Ahmet M and Hannon, Gregory J
Molecular Cell, ISSN 1097-2765, 2005, Volume 19, Issue 3, pp. 421 - 428
In plants, the RNA silencing machinery responds to numerous inputs, including viral infection, microRNAs, and endogenous siRNAs that may act both in and in .... 
MESSENGER-RNAS | DOUBLE-STRANDED-RNA | BINDING-PROTEIN HYL1 | GENE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DICER HOMOLOG | TRANS-ACTING SIRNAS | C-ELEGANS | PLANT DEVELOPMENT | DISTINCT ROLES | CELL BIOLOGY | RNA, Small Interfering - genetics | Arabidopsis Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | RNA, Messenger - genetics | RNA-Induced Silencing Complex - genetics | Cell Cycle Proteins - metabolism | MicroRNAs - metabolism | Signal Transduction - genetics | RNA, Messenger - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Extracts - metabolism | RNA Interference | Adenosine Triphosphate - metabolism | RNA, Double-Stranded - genetics | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Cell Cycle Proteins - genetics | MicroRNAs - genetics | RNA, Double-Stranded - metabolism | Mutation | RNA, Small Interfering - metabolism | Arabidopsis thaliana | Proteins | Virus diseases | Genetic research | Protein biosynthesis | Messenger RNA
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