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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 52, pp. 22505 - 22510
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3970 - 9
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2019, Volume 116, Issue 33, pp. 16535 - 16540
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e66530 - e66530
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 45, pp. 19151 - 19156
As influenza viruses have developed resistance towards current drugs, new inhibitors that prevent viral replication through different inhibitory mechanisms are... 
H1N1 subtype influenza A virus | RNA | Influenza A virus | Plasmids | Antivirals | Viruses | Orthomyxoviridae | Infections | Inhibitory concentration 50 | Genetic mutation | High-throughput screening | Chemical genetics | Influenza PB1 | Antiinfluenza | Influenza NP | VIRUS | PANDEMIC INFLUENZA | MULTIDISCIPLINARY SCIENCES | high-throughput screening | antiinfluenza | H1N1 | NEURAMINIDASE | influenza NP | chemical genetics | NUCLEOPROTEIN | influenza PB1 | DRUGS | RESISTANCE | INHIBITORS | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Humans | Nucleoproteins - genetics | RNA Replicase - antagonists & inhibitors | Viral Proteins - antagonists & inhibitors | Influenza A Virus, H1N1 Subtype - drug effects | Drug Resistance, Viral - genetics | Animals | Influenza A Virus, H1N1 Subtype - enzymology | Dogs | Influenza, Human - virology | Mice | Influenza, Human - drug therapy | Influenza, Human - prevention & control | High-Throughput Screening Assays - methods | Care and treatment | Influenza | Genetic aspects | Biochemical genetics | Research | Properties | RNA polymerases | Genetic screening | Methods | Proteins | RNA polymerase | Mutation | Ribonucleic acid--RNA | Chemical compounds | Index Medicus | Infection | Nucleoproteins | Influenza A | Replication | Drug resistance | DNA-directed RNA polymerase | RNA-directed RNA polymerase | Biological Sciences | Physical Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0154097 - e0154097
ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV)... 
SYSTEM | REPLICATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | DRUGS | L PROTEIN | INFECTION | PRIMER | HIV-1 REVERSE-TRANSCRIPTASE | VESICULAR STOMATITIS-VIRUS | RESPIRATORY SYNCYTIAL VIRUS | Niacinamide - analogs & derivatives | DNA-Directed RNA Polymerases - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Viral Proteins - metabolism | RNA, Viral - antagonists & inhibitors | RNA, Viral - genetics | Recombinant Proteins - metabolism | Antiviral Agents - pharmacology | Gene Expression | Cytidine Triphosphate - pharmacology | RNA, Viral - biosynthesis | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | DNA-Directed RNA Polymerases - genetics | Recombinant Proteins - genetics | Benzazepines - pharmacology | Drug Synergism | Point Mutation | Drug Resistance, Viral - genetics | Epithelial Cells - virology | Cell Line, Tumor | Cytidine Triphosphate - analogs & derivatives | Niacinamide - pharmacology | DNA-Directed RNA Polymerases - metabolism | Drug Combinations | Respiratory syncytial virus | Research | Gene mutations | Analysis | RNA polymerases | Risk factors | L protein | Cross-resistance | Amino acids | Viruses | Infections | RNA polymerase | Drug resistance | Ribonucleic acid--RNA | DNA-directed RNA polymerase | RNA-directed RNA polymerase | P protein | Polymerase | Hepatitis | Discrimination | Inhibitors | Antiviral activity | Nucleosides | Mutation | Inhibition | Cytidine triphosphate--CTP | Pharmaceutical industry | Nucleoside analogs | Index Medicus | Ribonucleic acids | CTP
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, pp. 7344 - 7349
Journal Article
Plant Cell, ISSN 1040-4651, 03/2017, Volume 29, Issue 3, pp. 508 - 525
Sumoylation is a transient, reversible dynamic posttranslational modification that regulates diverse cellular processes including plant-pathogen interactions.... 
SYSTEM | COMPLEX | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUMO-CONJUGATING ENZYME | PLANT SCIENCES | CELL BIOLOGY | GEMINIVIRUS REPLICATION PROTEIN | INFLUENZA-A VIRUS | GENE | ARABIDOPSIS | ACCUMULATION | LIVING CELLS | Arabidopsis Proteins - genetics | Potyvirus - pathogenicity | Tymovirus - pathogenicity | Plant Immunity - genetics | RNA Replicase - genetics | Protein Processing, Post-Translational - genetics | RNA Replicase - metabolism | Viral Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Plant Immunity - physiology | Viral Proteins - metabolism | Protein Processing, Post-Translational - physiology | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Sumoylation | Arabidopsis - virology | DNA-Directed RNA Polymerases - metabolism | Potyvirus - enzymology | Tymovirus - enzymology | Post-translational modification | Ubiquitin | Arabidopsis thaliana | Drug resistance in microorganisms | RNA | Health aspects | Turnips | Plant defenses | Analysis | Diseases and pests | Physiological aspects | Virus diseases of plants | Plant viruses | Pathogens | RNA viruses | Immune response | Viruses | Infections | RNA polymerase | DNA-directed RNA polymerase | Nuclei | Immunity | RNA-directed RNA polymerase | Immune systems | SUMO protein | Polymerase | Ribonucleic acids | Replication | Localization | Cytoplasm | Viral infections | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2012, Volume 48, Issue 2, pp. 313 - 321
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 07/2015, Volume 32, Issue 7, pp. 1788 - 1799
Journal Article