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Experimental Cell Research, ISSN 0014-4827, 06/2019, Volume 379, Issue 1, pp. 11 - 18
Post-translational modifications of the histone H2A represent an important mechanism by which cells modulate the structure and function of chromatin.... 
Cell proliferation | Histone H2A | USP28 | Deubiquitinases | RNF168 | ONCOLOGY | UBIQUITYLATION | COUNTERACTS | GAMMA-H2AX | SENESCENCE | PROGRESSION | CELL BIOLOGY | Tumor proteins
Journal Article
Chemical science, ISSN 2041-6520, 04/2018, Volume 9, Issue 15, pp. 3704 - 3709
The cellular response to DNA damage results in a signaling cascade that primes chromatin for repair. Combinatorial post-translational modifications (PTMs) play... 
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2018, Volume 355, pp. 238 - 246
DNA double-strand breaks (DSBs) are a highly toxic form of DNA damage produced by a number of carcinogens, drugs, and metabolic abnormalities. Involvement of... 
RNF168 | Histone H2AX | DNA double-strand break | DNA damage | Genotoxicity | ACTIVATION | CHROMATIN | PHOSPHORYLATION | INITIATION | MEDIATED CLEAVAGE | MISMATCH REPAIR | BRCA1 | Histone H2Ax | DAMAGE | PHARMACOLOGY & PHARMACY | ATM | TOXICOLOGY | Index Medicus | genotoxicity | histone H2AX
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 12/2014, Volume 57, pp. 27 - 34
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 12, pp. 3199 - 3211.e5
H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a... 
H2AX | RNF168 | PRMT5 | MTAP | glioblastoma | SMURF2 | METHYLATION | PROTEIN | RECOGNITION | METHYLTHIOADENOSINE | PHOSPHORYLASE MTAP EXPRESSION | UBIQUITIN | ARGININE METHYLTRANSFERASE | HISTONE H2AX | DNA-REPAIR | CELL BIOLOGY
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 11/2019, Volume 133, p. 110745
Cadmium (Cd) is a dispensable element for the human body and is usually considered a carcinogen. Occupational and environmental Cd exposure leads to sustained... 
RNF168 | Cadmium | Ubiquitination | DNA damage response | Double-stranded break | CANCER-SUSCEPTIBILITY | MDC1 | PROTEIN | FOOD SCIENCE & TECHNOLOGY | DOUBLE-STRAND BREAKS | BRCA1 | GENOMIC INSTABILITY | REPAIR | CELL-CYCLE | TOXICOLOGY | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION
Journal Article
Autophagy, ISSN 1554-8627, 11/2018, Volume 14, Issue 11, pp. 1976 - 1990
Recent reports have made important revelations, uncovering direct regulation of DNA damage response (DDR)-associated proteins and chromatin ubiquitination... 
RNF168 | USP14 | DNA damage response | Autophagy | deubiquitinase | INDUCED APOPTOSIS | DOUBLE-STRAND BREAKS | CELL BIOLOGY | GENOMIC INSTABILITY | PATHWAY | PROSTATE-CANCER | DEPENDENT UBIQUITINATION | DEGRADATION | HOMOLOGOUS RECOMBINATION | PROMOTES
Journal Article
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 502 - 505
Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a... 
UBIQUITINATION | RECOMBINATION | MAINTENANCE | COMPLEX | REPAIR | MAMMALIAN TELOMERES | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | CELL-CYCLE | PROTEINS | TRF2 | Tumor Suppressor Proteins - antagonists & inhibitors | Chromosomes, Mammalian - genetics | Protein Multimerization | Ubiquitin-Protein Ligases - antagonists & inhibitors | Telomeric Repeat Binding Protein 2 - chemistry | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Telomere - metabolism | Protein-Serine-Threonine Kinases - metabolism | Telomere - genetics | Protein Structure, Tertiary | Endopeptidases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Ataxia Telangiectasia Mutated Proteins | Endopeptidases - deficiency | Protein Transport | Animals | DNA Repair | Telomeric Repeat Binding Protein 2 - metabolism | Mice | DNA Damage | Enzyme Activation | Tumor Suppressor p53-Binding Protein 1 | Chromosomes, Mammalian - metabolism | Telomeres | Research | Binding proteins | Observations | Properties | DNA damage | Proteins | Enzymes | DNA methylation | Amino acids | Agreements | Telomerase | Chromosomes | RNF168 | Brca1 | genomic stability | telomere | ATM | NHEJ
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2019, Volume 73, Issue 6, pp. 1267 - 1281.e7
Journal Article
Journal Article