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Pathology - Research and Practice, ISSN 0344-0338, 08/2019, Volume 215, Issue 8, p. 152453
The truncating mutations of RNF43 frequently occur in CRC, we aimed to clarify the relationship between RNF43 frameshift mutations and MS status, BRAF V600E... 
Frameshift mutation | RNF43 | Microsatellite status | Colorectal cancer | MICROSATELLITE INSTABILITY | COLORECTAL-CANCER | PATHOLOGY | WNT | TUMOR-SUPPRESSOR RNF43
Journal Article
CARCINOGENESIS, ISSN 0143-3334, 04/2019, Volume 40, Issue 4, pp. 551 - 559
Ring finger protein 43 (RNF43) is an E3 ubiquitin ligase that has been described to be frequently mutated in gastrointestinal cancers. RNF43 downregulation was... 
SUPPRESSOR RNF43 | GENE | ONCOLOGY | PATHWAY | INFLAMMATION | RECURRENT MUTATIONS | CANCER | TUMORIGENESIS
Journal Article
CANCERS, ISSN 2072-6694, 03/2019, Volume 11, Issue 3, p. 372
The E3 ubiquitin ligase ring finger protein 43 (RNF43) is frequently mutated in gastric tumors and loss of RNF43 expression was suggested to be one of the key... 
RNF43 | STEM-CELLS | ACTIVATION | RECEPTOR CD44 | H. pylori | PROLIFERATION | BETA-CATENIN | TUMOR-SUPPRESSOR RNF43 | gastric pathology | CARCINOGENESIS | ONCOLOGY | MUTATIONS | WNT | NF-KAPPA-B
Journal Article
Modern Pathology, ISSN 0893-3952, 10/2018, Volume 31, Issue 10, pp. 1588 - 1598
We describe a series of colorectal polyps characterized by mixed adenomatous and serrated features, herein referred to as superficially serrated adenomas.... 
KRAS MUTATIONS | HYPERPLASTIC POLYPS | RNF43 | GENE | PATHWAY | DYSPLASIA | FUSIONS | PATHOLOGY | CANCER | TUMORIGENESIS | DEFICIENCY | Immunohistochemistry | β-catenin | Wnt protein | Glands | Genetic analysis | Rectum | Adenoma | Mutation | Colon | Polyps | Tumors
Journal Article
Oncogene, ISSN 0950-9232, 04/2016, Volume 35, Issue 17, pp. 2197 - 2207
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2016, Volume 7, Issue 7, pp. 676 - 680
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for... 
Porcupine inhibitor | Wnt signaling | WNT SIGNALING PATHWAY | RNF43 | CHEMISTRY, MEDICINAL | DRIVEN | CANCER
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 06/2018, Volume 14, Issue 6, pp. 582 - 582
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express... 
SYSTEM | RNF43 | IN-VITRO | PATHWAY | WNT RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | CRYPT | CRYSTALLOGRAPHY | MODEL | REVEALS | Binding | G protein-coupled receptors | Wnt protein | Peptides | Frizzled protein | Lipids | Leucine | Peptide inhibitors | Epithelium | Embryos | Proteins | Regeneration | Signaling | Receptors | Organoids | Intestine | Stem cells | Isoforms | Drug discovery
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 01/2019, Volume 43, Issue 1, pp. 132 - 139
Colorectal traditional serrated adenomas (TSAs) are often associated with precursor polyps, including hyperplastic polyps and sessile serrated adenoma/polyps.... 
sessile serrated adenoma/polyp | traditional serrated adenoma | WNT | hyperplastic polyp | SURGERY | RNF43 | NEOPLASTIC PROGRESSION | DISTINCT | C-MYC | BRAF | PATHOLOGY | APC | MUTATIONS | FUSIONS | Development and progression | Polyps (Pathology) | Cellular signal transduction | Genetic aspects | Research | Gene mutations
Journal Article
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, ISSN 0893-3952, 04/2019, Volume 32, Issue 10, pp. 1390 - 1415
Our understanding of serrated colorectal polyps has increased dramatically over the past two decades and has led to a modern classification scheme for these... 
ISLAND METHYLATOR PHENOTYPE | GERMLINE RNF43 MUTATIONS | HYPERPLASTIC POLYPS | METACHRONOUS POLYPS | AGGRESSIVE ADENOCARCINOMA | ADVANCED NEOPLASIA | MICROSATELLITE INSTABILITY | LOW CIMP-LOW | PROXIMAL COLON | CONVENTIONAL ADENOMAS | PATHOLOGY | Immunohistochemistry | Dysplasia | MLH1 protein | Colorectal carcinoma | Classification | Colon | Polyps
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Proteins | Viral antibodies | Genomics | Colorectal cancer | Antibodies | Genomes | Genetic screening | Cell proliferation | Adenocarcinoma | CRISPR | Therapy | Immunoglobulins | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Cell surface | Signaling | Receptors | Organoids | Xenografts | Inhibition | Mutation | Pancreas | Cancer | Tumors | Recombinant
Journal Article
Cell Reports, ISSN 2211-1247, 02/2019, Volume 26, Issue 9, pp. 2266 - 2273.e4
Wnt signals at the base of mammalian crypts play a pivotal role in intestinal stem cell (ISC) homeostasis, whereas aberrant Wnt activation causes colon cancer.... 
intestinal stem cell | colorectal cancer | Wnt | Sh3bp4 | RNF43 | ACTIVATION | DOMAIN | COLORECTAL-CANCER | MUTATION | TUMOR-SUPPRESSOR | COLON | NEGATIVE REGULATOR | CELL BIOLOGY
Journal Article