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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2004, Volume 573, Issue 1, pp. 175 - 180
Histamine and thrombin cause phosphorylation and activation of endothelial NO‐synthase (eNOS) on Ser1177. We tested the role of various protein kinases in... 
Histamine | AMPK | Thrombin | eNOS | Endothelial cell | ACC, acetyl-CoA carboxylase | PLC, phospholipase C | ATP, adenosine 5 | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | cyclic monophosphate | eNOS, endothelial NO-synthase | AMP-activated protein kinase | CaMKII, Ca | NO, nitric oxide | ROCK, Rho-dependent protein kinase | AMP, adenosine 5 | AMPK, 5 | HUVEC, human umbilical vein endothelial cells | PKC, protein kinase C | cAMP, adenosine 3 | calmodulin-dependent protein kinase II | AICAR, 5-aminoimidazole-4-carbozamide-1-β-4 ribofuranoside | PKA, protein kinase A | monophosphate | triphosphate | AICAR, 5-aminoimidazole-4-carbozamide-1-β- 4 ribofuranoside | Calcium - metabolism | Humans | Multienzyme Complexes - metabolism | Phosphatidylinositol 3-Kinases - metabolism | AMP-Activated Protein Kinases | Thrombin - pharmacology | Protein Kinase C - metabolism | Phosphorylation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Calcium - pharmacology | Histamine - pharmacology | Endothelial Cells - metabolism | Nitric Oxide Synthase Type III | Enzyme Activation - drug effects | Phosphoserine - metabolism | Proto-Oncogene Proteins c-akt | Signal Transduction - drug effects | Nitric Oxide Synthase - metabolism | Epidermal Growth Factor - pharmacology | Endothelial Cells - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Endothelial Cells - drug effects | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2009, Volume 296, Issue 3, pp. 893 - 899
Vascular endothelial growth factor (VEGF) is an endothelial-specific growth factor that activates the small GTPase RhoA. While the role of RhoA for VEGF-driven... 
Angiogenesis | Rho-dependent kinases rock i and rock ii | Retinal neovascularization | Vascular endothelial growth factor | Endothelial signaling | endothelial signaling | SURVIVAL | RECEPTOR-2 KDR | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PHOSPHORYLATION | angiogenesis | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | Rho-dependent kinases ROCK I and ROCK II | CELL MIGRATION | IN-VITRO | vascular endothelial growth factor | retinal neovascularization | P160(ROCK) | PERIPHERAL VASCULAR DISEASE | COILED-COIL | ENDOTHELIAL GROWTH-FACTOR | Neovascularization, Physiologic - drug effects | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Vascular Endothelial Growth Factor A - metabolism | rho-Associated Kinases - antagonists & inhibitors | Dose-Response Relationship, Drug | Receptors, Vascular Endothelial Growth Factor - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Retinal Neovascularization - enzymology | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Angiogenesis Inducing Agents - pharmacology | Disease Models, Animal | Animals, Newborn | Oxygen | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | rho-Associated Kinases - genetics | Phthalazines - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Retinal Neovascularization - chemically induced | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Retinal Neovascularization - physiopathology | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Proteins | Signal transduction | Kidneys | Rodents | Physiology | Kinases | Cells | Index Medicus
Journal Article
American Journal of Physiology, ISSN 0363-6135, 08/2018, Volume 315, Issue 2, p. H314
Aaronson discusses the study conducted by Weise-Cross et al. reporting the novel finding that the effect of RhoA/ROCK contributes 10 the increases in both... 
Reactive oxygen species | Calcium | Pulmonary arteries | Lung | Polymerization | Rats | RhoA protein | Endothelin 1 | Arteries | Rho-associated kinase | Cytochalasin B | Actin | Rodents | Hypoxia | Rocks | Calcium ions
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2004, Volume 75, Issue 6, pp. 1173 - 1182
Journal Article
Journal Article
Pulmonary Circulation, ISSN 2045-8932, 6/2017, Volume 7, Issue 3, pp. 617 - 623
Increased exposure to ambient particulate matter (PM) is associated with elevated morbidity and mortality in patients with cardiopulmonary diseases and cancer.... 
ROCK | Endothelial barrier | Particulate matter | Myosin light chain | LIGHT-CHAIN KINASE | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOSIN | PHOSPHORYLATION | endothelial barrier | VASCULAR-PERMEABILITY | particulate matter | AIR-POLLUTION | myosin light chain | CITY | RESPIRATORY SYSTEM | INFLAMMATION | PM2.5
Journal Article