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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2009, Volume 296, Issue 3, pp. 893 - 899
.... While the role of RhoA for VEGF-driven endothelial migration and angiogenesis has been studied in detail, the function of its target proteins, the Rho-dependent kinases ROCK I and II, are controversially discussed... 
Angiogenesis | Rho-dependent kinases rock i and rock ii | Retinal neovascularization | Vascular endothelial growth factor | Endothelial signaling | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Neovascularization, Physiologic - drug effects | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Vascular Endothelial Growth Factor A - metabolism | rho-Associated Kinases - antagonists & inhibitors | Dose-Response Relationship, Drug | Receptors, Vascular Endothelial Growth Factor - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Retinal Neovascularization - enzymology | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Angiogenesis Inducing Agents - pharmacology | Disease Models, Animal | Animals, Newborn | Oxygen | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | rho-Associated Kinases - genetics | Phthalazines - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Retinal Neovascularization - chemically induced | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Retinal Neovascularization - physiopathology | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 08/2018, Volume 315, Issue 2, p. H314
Aaronson discusses the study conducted by Weise-Cross et al. reporting the novel finding that the effect of RhoA/ROCK contributes 10 the increases in both... 
Calcium | Pulmonary arteries | Polymerization | Rats | RhoA protein | Endothelin 1 | Arteries | Rho-associated kinase | Cytochalasin B | Actin | Rodents | Hypoxia | Rocks | Calcium ions
Journal Article
Frontiers in pharmacology, 11/2015, Volume 6
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC... 
Heart | cardiovascular disease | rho-kinase | inhibitor | Fibrosis | Hypertrophy
Journal Article
FEBS letters, ISSN 0014-5793, 2004, Volume 573, Issue 1, pp. 175 - 180
.... We tested the role of various protein kinases in mediating this effect in human umbilical vein endothelial cells... 
Histamine | AMPK | Thrombin | eNOS | Endothelial cell | ACC, acetyl-CoA carboxylase | PLC, phospholipase C | HUVEC, human umbilical vein endothelial cells | cAMP, adenosine 3′5′-cyclic monophosphate | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKC, protein kinase C | AMPK, 5′-AMP-activated protein kinase | eNOS, endothelial NO-synthase | ATP, adenosine 5′-triphosphate | AMP, adenosine 5′-monophosphate | AICAR, 5-aminoimidazole-4-carbozamide-1-β-4 ribofuranoside | NO, nitric oxide | ROCK, Rho-dependent protein kinase | CaMKII, Ca2+/calmodulin-dependent protein kinase II | PKA, protein kinase A | AICAR, 5-aminoimidazole-4-carbozamide-1-β- 4 ribofuranoside | ATP, adenosine 5 | AMP, adenosine 5 | AMP-activated protein kinase | AMPK, 5 | monophosphate | triphosphate | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Calcium - metabolism | Humans | Multienzyme Complexes - metabolism | Phosphatidylinositol 3-Kinases - metabolism | AMP-Activated Protein Kinases | Thrombin - pharmacology | Protein Kinase C - metabolism | Phosphorylation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Calcium - pharmacology | Histamine - pharmacology | Endothelial Cells - metabolism | Nitric Oxide Synthase Type III | Enzyme Activation - drug effects | Phosphoserine - metabolism | Proto-Oncogene Proteins c-akt | Signal Transduction - drug effects | Nitric Oxide Synthase - metabolism | Epidermal Growth Factor - pharmacology | Endothelial Cells - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Endothelial Cells - drug effects | Index Medicus
Journal Article
Pulmonary circulation, ISSN 2045-8940, 06/2017, Volume 7, Issue 3, pp. 617 - 623
...) phosphorylation and EC barrier disruption measured by transendothelial electrical resistance (TER), events attenuated by the Rho-dependent kinase... 
ROCK | Endothelial barrier | Particulate matter | Myosin light chain | Cardiac & Cardiovascular Systems | Respiratory System | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Phosphatase | Phosphorylation
Journal Article