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Journal of Cellular Physiology, ISSN 0021-9541, 07/2019, Volume 234, Issue 7, pp. 11511 - 11523
Journal Article
International Journal of Oncology, ISSN 1019-6439, 10/2017, Volume 51, Issue 4, pp. 1209 - 1218
Rho-associated protein kinase 1 (ROCK1), a serine/threonine kinase, has previously been shown to be over expressed in various types of human malignant tumors... 
Papillary Thyroid Carcinoma | Prognosis | Metastasis | ROCK1 | MMP-9 | RISK-FACTORS | prognosis | BREAST-CANCER | MATRIX METALLOPROTEINASES | LYMPH-NODE METASTASIS | ONCOLOGY | metastasis | DOWN-REGULATING ROCK1 | CELL-MIGRATION | PROSTATE-CANCER | MOUSE MODEL | TARGETING ROCK1 | papillary thyroid carcinoma | CLINICOPATHOLOGICAL FEATURES
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 02/2020, Volume 235, Issue 2, pp. 1197 - 1208
Chemotherapy is the first‐line treatment option for patients with lung cancer. However, therapeutic resistance occurs through an incompletely understood... 
lung cancer | Cav‐1 | apoptosis | mitophagy | ROCK1
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 11/2019, Volume 373, p. 112083
Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors.... 
Anxiety | Rho kinase | ROCK1 | ROCK2 | Fasudil
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2015, Volume 309, Issue 11, pp. L1323 - L1332
Journal Article
Oncotarget, 2016, Volume 7, Issue 38, pp. 61619 - 61629
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 496, Issue 2, pp. 536 - 541
Farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway, was recently shown to play a role in cancer progression. However, its role in... 
TGF-β1 | RhoA/Rock1 | FPPS | EMT | Non-small cell lung cancer
Journal Article
by Liu, JL and Li, J and Xu, JJ and Xiao, F and Cui, PL and Qiao, ZG and Chen, XD and Tao, WD and Zhang, XL
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 04/2019, Volume 95, Issue 4, pp. 451 - 461
Several microRNAs (miRNAs) have been found expressed differentially in osteosarcoma (OS), so they may function in the onset and progression of OS. In this... 
MIGRATION | SURVIVAL | INVASION | ACTIVATION | PROTEIN-KINASE | RHO | PHARMACOLOGY & PHARMACY | PROLIFERATION | TARGETING ROCK1 | CANCER PROGRESSION | MICRORNA EXPRESSION PROFILES
Journal Article
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 3, pp. 733 - 740
Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in... 
proteasome | YB-1 | cell cycle | translation | long non-coding RNA | Rock1 | myogenesis | lnc-31 | protein stability | YB-1 PROMOTES | SKELETAL-MUSCLE | LOCALIZATION | MUSCLE DIFFERENTIATION | ACTIVATION | MYOGENIC DIFFERENTIATION | TRANSCRIPTION | NEURAL ACTIVITY | MYOBLAST FUSION | EXPRESSION | CELL BIOLOGY
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 12/2019, Volume 120, p. 109423
Ovarian cancer is one of the most common malignant tumors of female genital organs. Long non-coding RNAs play an important role in the progression of ovarian... 
miR-148a-3p | LINC00339 | ROCK1 | Ovarian cancer cells | Invasion | Long non-coding RNA
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2017, Volume 28, Issue 22, pp. 9879 - 9884
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 8/2016, Volume 138, Issue 4, pp. 525 - 531
Alzheimer’s disease (AD) is the leading cause of dementia and mitigating amyloid-β (Aβ) levels may serve as a rational therapeutic avenue to slow AD... 
amyloid-β | mild cognitive impairment | Alzheimer’s disease | Rho kinase | ROCK1 | ROCK2
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2019, Volume 859, p. 172535
Long non-coding RNAs (lncRNAs) have emerged as crucial regulatory factors in diverse pathological processes, especially in tumorigenesis. Accumulating evidence... 
miR-340-5p | ROCK1 | LINC00662 | Acute myeloid leukemia | TARGET | METASTASIS | PROGNOSIS | PROLIFERATION | MECHANISMS | MIR-340 | INVASION | PHARMACOLOGY & PHARMACY | SUPPRESSES | CARCINOMA | PROGRESSION
Journal Article
Life Sciences, ISSN 0024-3205, 10/2019, Volume 235, p. 116829
Nonalcoholic fatty liver disease (NAFLD) is a severe liver disease, which influences the health of people worldwide. However, the specific mechanism of the... 
miR-146a-5p | NAFLD | ROCK1 | NEAT1 | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | RECEPTOR | PHARMACOLOGY & PHARMACY | PROLIFERATION | NONCODING RNA NEAT1 | MICRORNAS | EXPRESSION
Journal Article
by Lu, YC and Wang, P and Wang, J and Ma, R and Lee, SC
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 07/2019, Volume 234, Issue 7, pp. 11511 - 11523
We have recently reported that type 2 diabetes promotes centrosome amplification via enhancing the expression, biding, and centrosome translocation of... 
PHYSIOLOGY | PCNA | INSTABILITY | ROCK1 | PHOSPHORYLATION | 14-3-3 sigma | KINASE | JNK1 | NPM | CELL BIOLOGY | centrosome amplification | SIGNAL-TRANSDUCTION | NUCLEOPHOSMIN | INVASION | Stat3 | DUPLICATION | diabetes | EXPRESSION | TUMORIGENESIS
Journal Article
Tetrahedron, ISSN 0040-4020, 02/2019, Volume 75, Issue 8, pp. 1029 - 1033
The insect have been used as an ethnomedicine in China for the treatment of several disorders such as cancer and inflammation. Our investigation with this... 
COX-2 | ROCK1 | Cytotoxicity | Phenolic compounds | Insect | JAK3 | Blaps japanensis | POLYRHACHIS-DIVES | ASPONGOPUS-CHINENSIS | A-C | CHEMISTRY, ORGANIC | Prevention | Cancer cells | Cancer
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2019, Volume 1865, Issue 6, pp. 1113 - 1125
Vasculogenic mimicry (VM) results in the formation of an alternative circulatory system that can improve the blood supply to multiple malignant tumors,... 
Hepatocellular carcinoma | ROCK1 | RhoC | ROCK2 | Vasculogenic mimicry | CELLS | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CANCER | INVASION | BIOPHYSICS | MMP-2 | EXPRESSION | INHIBIT | Drugstores | Medical colleges | Hepatoma | Pharmacy | Stem cells
Journal Article
by Fan, GT and He, ZW and Cao, LL and Shi, X and Wu, SJ and Zhou, GX
FRONTIERS IN BIOSCIENCE-LANDMARK, ISSN 1093-9946, 03/2019, Volume 24, pp. 1167 - 1177
miR-139 has a tumor suppressor effect in many tumors. Here, we examined the suppressive role of this miRNA and its target, ROCK1, in osteosarcoma (OS), a... 
MIGRATION | APOPTOSIS | METASTASIS | ROCK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | Proliferation | MICRORNAS | miR-139 | Invasion | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | REGULATOR | Osteosarcoma | COLORECTAL-CANCER | GROWTH
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2014, Volume 15, Issue 16, pp. 6543 - 6546
MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers,... 
miR-124 | migration | Proliferation | ROCK1 | Gastric cancer | Invasion | proliferation | DOWN-REGULATION | CELL-PROLIFERATION | MICRORNAS | GLIOBLASTOMA | invasion | ONCOLOGY | SUPPRESSES | EXPRESSION | PROMOTES
Journal Article
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