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Experimental Cell Research, ISSN 0014-4827, 12/2019, Volume 385, Issue 2, p. 111689
Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) are widely involved in cell... 
Ubiquitination | PFKFB3 | Proliferation | ROCK2 | Migration | Invasion
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 11/2019, Volume 373, p. 112083
Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors.... 
Anxiety | Rho kinase | ROCK1 | ROCK2 | Fasudil
Journal Article
The Application of Clinical Genetics, ISSN 1178-704X, 08/2016, Volume 2016, Issue Issue 1, pp. 137 - 139
Gaurav Sikri, Srinivasa Bhattachar Department of Physiology, Armed Forces Medical College, Pune, Maharashtra, IndiaWe have read the article titled "ROCK2 and... 
ROCK2;MYLK variants | HAPE
Journal Article
Biochimica et Biophysica Acta. C, Molecular Cell Research, ISSN 0167-4889, 2015, Volume 1853, Issue 7, pp. 1606 - 1614
Rotenone (ROT) is a widely used inhibitor of complex I (CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system. However,... 
murine myotube formation | ROCK2 | Raf-1 | Rotenone
Journal Article
International Journal of Cardiology, ISSN 0167-5273, 04/2019, Volume 281, pp. 90 - 98
Diabetes is associated with an increased risk of heart failure, cardiac arrhythmias and sudden cardiac death. We previously showed that ROCK2 expression is... 
Diabetic cardiomyopathy | Ca2+ leak | ROCK2 | Ryanodine receptor | leak | TRIGGERED ACTIVITY | HOMEOSTASIS | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOPATHY | RHO-KINASE | RISK | DEATH | DIASTOLIC DYSFUNCTION | CAMKII | Ryanociine receptor | INHIBITION | STREPTOZOTOCIN | Heart | Heart cells
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 5, pp. e1225 - e1225
The Rho/ROCK/LIMK pathway is central for the mediation of repulsive environmental signals in the central nervous system. Several studies using pharmacological... 
Regeneration | Retinal ganglion cells | ROCK2 | Axonal degeneration | Optic nerve crush | LIMK1 | APOPTOSIS | RHO-KINASE INHIBITION | SIGNALING PATHWAYS | ACTIVATION | regeneration | PHOSPHORYLATION | LIM-KINASE | axonal degeneration | optic nerve crush | CELL BIOLOGY | RETINAL GANGLION-CELLS | NEURITE OUTGROWTH | IN-VIVO | GROWTH | retinal ganglion cells | Dependovirus - genetics | Optic Nerve - pathology | Phosphorylation | Axons - enzymology | Calpain - metabolism | Rats, Wistar | Neurites - enzymology | Caspase 3 - metabolism | Autophagy | Gene Knockdown Techniques | Lim Kinases - metabolism | Retinal Ganglion Cells - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | RNA Interference | Time Factors | rho-Associated Kinases - metabolism | Cell Death | Female | Optic Nerve Injuries - pathology | Optic Nerve - physiopathology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Gene Transfer Techniques | Optic Nerve - enzymology | Retinal Ganglion Cells - enzymology | Signal Transduction | Optic Nerve Injuries - physiopathology | Cells, Cultured | Nerve Crush | Rats | rho-Associated Kinases - genetics | Nerve Regeneration | Nerve Tissue Proteins - metabolism | Neurites - pathology | Optic Nerve Injuries - enzymology | Optic Nerve Injuries - genetics | Animals | Axons - pathology | Lim Kinases - genetics | Genetic Vectors | Nerve Degeneration | Apoptosis | Original
Journal Article
Brain Research, ISSN 0006-8993, 11/2019, p. 146555
Journal Article
Chinese Journal of Natural Medicines, ISSN 1875-5364, 07/2019, Volume 17, Issue 7, pp. 506 - 516
MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their... 
ROCK2/MLC signaling | Volatile oil | MSC | Migration | Catharmus tinctorius
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 8/2016, Volume 138, Issue 4, pp. 525 - 531
Alzheimer’s disease (AD) is the leading cause of dementia and mitigating amyloid-β (Aβ) levels may serve as a rational therapeutic avenue to slow AD... 
amyloid-β | mild cognitive impairment | Alzheimer’s disease | Rho kinase | ROCK1 | ROCK2
Journal Article
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2019, Volume 1865, Issue 6, pp. 1113 - 1125
Vasculogenic mimicry (VM) results in the formation of an alternative circulatory system that can improve the blood supply to multiple malignant tumors,... 
Hepatocellular carcinoma | ROCK1 | RhoC | ROCK2 | Vasculogenic mimicry | CELLS | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CANCER | INVASION | BIOPHYSICS | MMP-2 | EXPRESSION | INHIBIT | Drugstores | Medical colleges | Hepatoma | Pharmacy | Stem cells
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 05/2018, Volume 89, pp. 125 - 138
Rho-associated kinase (ROCK) has been found to be involved in the pathogenesis of a variety of autoimmune diseases, but the role of ROCK in inflammatory bowel... 
IBD | Slx-2119 | ROCK2 | T cell differentiation | IMMUNE CELLS | PHOSPHORYLATION | MICROBIOTA | IMMUNOLOGY | IL-21 | PATHOGENESIS | RHO KINASE BLOCKADE | INHIBITION | THERAPY | IL-17 | REGULATORS
Journal Article
Tetrahedron, ISSN 0040-4020, 11/2018, Volume 74, Issue 46, pp. 6667 - 6672
Alokicenones A-H ( ), eight new tetrahydroanthracenes and one known okicenone ( ) were identified from the secondary metabolites of mangrove-derived sp.... 
Mangrove-derived Streptomyces | Cytotoxicity | ROCK2 inhibitory activities | BRD4 inhibitory activities | Alokicenones A-H | SOILS | CHEMISTRY, ORGANIC | DISCOVERY | BROMODOMAINS | TARGETS | DERIVATIVES | ALOE | CONSTITUENTS | HAW | Marine biology | Plant metabolites
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 08/2016, Volume 138, Issue 4, pp. 525 - 531
Alzheimer's disease (AD) is the leading cause of dementia and mitigating amyloid- (A) levels may serve as a rational therapeutic avenue to slow AD progression.... 
Rho kinase | ROCK1 | MECHANISM | ROCK2 | PHOSPHORYLATION | BETA PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNAPSE | NEUROSCIENCES | DEGENERATION | amyloid | INHIBITION | mild cognitive impairment | MICE | Alzheimer's disease | GROWTH CONE | Brain | Protein kinases | Amyloid beta-protein | Target marketing | Proteins | Neurochemistry | Kinases | Alzheimers disease
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2019, Volume 155, pp. 150 - 161
Lysophosphatidic acid (LPA) is a bioactive lipid mediator of inflammation that binds to its specific cell surface G protein coupled receptors (LPA1-6). It is... 
Depression | Neuronal apoptosis | ROCK2 | RhoA | LPA1 | RHO-FAMILY GTPASES | BEHAVIOR | CELL APOPTOSIS | MODEL | NEUROSCIENCES | LYSOPHOSPHATIDIC ACID | PATHWAY | INFLAMMATION | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | EXPRESSION | G proteins | Neurons | Depression, Mental | Apoptosis
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 09/2014, Volume 115, Issue 9, pp. 1516 - 1527
ABSTRACT Prostaglandin E2 is a pleiotropic bioactive lipid that controls cytoskeletal alterations, although the precise G‐protein coupled EP receptor... 
FIBROSIS | ROCK2 | MYOFIBROBLASTS | PROSTAGLANDIN E2 (PGE2) | FIBROBLASTS | STRESS FIBRES | MYOSIN LIGHT CHAIN | Phosphotransferases | Prostaglandins E | Analysis
Journal Article
International journal of cancer. Journal international du cancer, ISSN 0020-7136, 8/2010, Volume 127, Issue 3, pp. 505 - 512
Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC). Previously, we reported... 
migration | miR-138 | invasion | RhoC | ROCK2
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 12/2019, Volume 64, Issue 12, pp. 3539 - 3548
Characterization of genetic aberrations provides novel strategies for diagnosis and treatment of gastric cancer. Accumulating evidence has shown the... 
Biochemistry, general | Medicine & Public Health | ROCK2 | Hepatology | hsa-miR-4529-5p | Gastroenterology | LncRNA | Oncology | MHRT | Gastric cancer | Transplant Surgery
Journal Article
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