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1. Full Text Two mouse retinal degenerations caused by missense mutations in the β-subunit of rod cGMP phosphodiesterase gene
by Chang, B and Hawes, N.L and Pardue, M.T and German, A.M and Hurd, R.E and Davisson, M.T and Nusinowitz, S and Rengarajan, K and Boyd, A.P and Sidney, S.S and Phillips, M.J and Stewart, R.E and Chaudhury, R and Nickerson, J.M and Heckenlively, J.R and Boatright, J.H
Vision research (Oxford), ISSN 0042-6989, 2007, Volume 47, Issue 5, pp. 624 - 633
rd10 | β-Phosphodiesterase | Rod photoreceptor | Retinitis pigmentosa | Retinal degeneration | Mouse model | nmf137 | PDE6b | cGMP-PDE | rd1 | β-Subunit of rod cGMP phosphodiesterase gene | Neurosciences | Social Sciences | Life Sciences & Biomedicine | Psychology | Ophthalmology | Neurosciences & Neurology | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Eye and associated structures. Visual pathways and centers. Vision | Retinopathies | Biological and medical sciences | Medical sciences | Electroretinography | Phosphoric Diester Hydrolases - metabolism | Retinal Degeneration - genetics | Mice, Inbred C57BL | Molecular Sequence Data | Phosphoric Diester Hydrolases - genetics | Mutation, Missense | Dark Adaptation | Phenotype | Animals | Base Sequence | Retinal Rod Photoreceptor Cells - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 6 | Mice | Eye Proteins - genetics | Retinal Degeneration - pathology | Retinal Degeneration - enzymology | Apoptosis | Disease Models, Animal | Index Medicus | retinal degeneration | mouse model | beta-subunit of rod cGMP phosphodiesterase gene | retinitis pigmentosa | rod photoreceptor | betaphosphodiesterase
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2. Full Text Photoreceptor cGMP Phosphodiesterase δ Subunit (PDEδ) Functions as a Prenyl-binding Protein
by Zhang, Houbin and Liu, Xiao-Hui and Zhang, Kai and Chen, Ching-Kang and Frederick, Jeanne M and Prestwich, Glenn D and Baehr, Wolfgang
The Journal of biological chemistry, ISSN 0021-9258, 01/2004, Volume 279, Issue 1, pp. 407 - 413
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Immunohistochemistry | Amino Acid Sequence | Recombinant Fusion Proteins - isolation & purification | Cysteine | Molecular Sequence Data | 3',5'-Cyclic-GMP Phosphodiesterases - analysis | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | Recombinant Fusion Proteins - chemistry | Protein Prenylation | Recombinant Fusion Proteins - metabolism | Photoreceptor Cells, Vertebrate - enzymology | Peptide Fragments - chemistry | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Animals | GTP Phosphohydrolases - metabolism | Cattle | Retinal Rod Photoreceptor Cells - cytology | Retinal Rod Photoreceptor Cells - enzymology | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 6 | Mice | Kinetics | Index Medicus
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3. Full Text Transducin activates cGMP phosphodiesterase by trapping inhibitory γ subunit freed reversibly from the catalytic subunit in solution
by Asano, Teizo and Kawamura, Satoru and Tachibanaki, Shuji
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 7245 - 7245
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Trapping | Cyclic GMP | Transducin | Photoreceptors | Rods | Kinases | Binding sites | Phosphodiesterase | Catalytic subunits | Index Medicus
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4. Full Text Functional analysis of the rod photoreceptor cGMP phosphodiesterase α-subunit gene promoter: Nrl and Crx are required for full transcriptional activity
by Pittler, Steven J and Zhang, Youwen and Chen, Shiming and Mears, Alan J and Zack, Donald J and Ren, Zhiyong and Swain, Prabodh K and Yao, Suxia and Swaroop, Anand and White, J. Brandon
The Journal of biological chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 19800 - 19807
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Retina - metabolism | Luciferases - metabolism | Humans | Transcriptional Activation | Molecular Sequence Data | Trans-Activators - physiology | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Transfection | Genes, Dominant | Time Factors | DNA Mutational Analysis | Base Sequence | Cloning, Molecular | Polymerase Chain Reaction | Retinal Rod Photoreceptor Cells - enzymology | beta-Galactosidase - metabolism | Adenoviridae - genetics | Transcription, Genetic | Binding Sites | Cell Line | Promoter Regions, Genetic | DNA-Binding Proteins - physiology | Glutathione Transferase - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | DNA - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Mice, Knockout | Deoxyribonuclease I - metabolism | Animals | Protein Binding | Cyclic Nucleotide Phosphodiesterases, Type 6 | Eye Proteins - physiology | Mice | Mutation | Homeodomain Proteins - physiology | Basic-Leucine Zipper Transcription Factors | Calcium Phosphates - metabolism | Index Medicus
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5. Full Text It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
by Qureshi, Bilal M and Behrmann, Elmar and Schöneberg, Johannes and Loerke, Justus and Bürger, Jörg and Mielke, Thorsten and Giesebrecht, Jan and Noé, Frank and Lamb, Trevor D and Hofmann, Klaus Peter and Spahn, Christian M. T and Heck, Martin
Open biology, ISSN 2046-2441, 08/2018, Volume 8, Issue 8, p. 180075
PDE6 | noise filtering | coincidence switch | density switch | visual signal transduction | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Retinal Rod Photoreceptor Cells - metabolism | Transducin - chemistry | Hydrolysis | Animals | Cyclic GMP - metabolism | Cattle | Protein Binding | Transducin - metabolism | Cell Membrane - metabolism | Enzyme Activation | Binding Sites | Index Medicus | pde6
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6. Full Text Functional Rescue of Degenerating Photoreceptors in Mice Homozygous for a Hypomorphic cGMP Phosphodiesterase 6 b Allele (Pde6bH620Q)
by Davis, Richard J and Tosi, Joaquin and Janisch, Kerstin M and Kasanuki, J. Mie and Wang, Nan-Kai and Kong, Jian and Tsui, Ilene and Cilluffo, Marianne and Woodruff, Michael L and Fain, Gordon L and Lin, Chyuan-Sheng and Tsang, Stephen H
Investigative ophthalmology & visual science, ISSN 0146-0404, 11/2008, Volume 49, Issue 11, pp. 5067 - 5076
Life Sciences & Biomedicine | Ophthalmology | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Biological and medical sciences | Eye and associated structures. Visual pathways and centers. Vision | Medical sciences | Rod Cell Outer Segment - physiopathology | Rod Cell Outer Segment - metabolism | Calcium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Retinal Degeneration - metabolism | Rod Cell Outer Segment - ultrastructure | Cell Death | Mice, Inbred DBA | Intracellular Fluid - metabolism | Electroretinography | Cell Line | Gene Expression | Signal Transduction | Retinal Degeneration - genetics | Electrophoresis, Polyacrylamide Gel | Mice, Inbred C57BL | Microscopy, Electron | Blotting, Western | Mice, Inbred C3H | DNA - genetics | Homozygote | Microscopy, Confocal | Animals | Alleles | Mice | Mutation | Retinal Degeneration - pathology | Index Medicus
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7. Full Text Quantitative aspects of cGMP phosphodiesterase activation in carp rods and cones
by Koshitani, Yuki and Tachibanaki, Shuji and Kawamura, Satoru
The Journal of biological chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 5, pp. 2651 - 2657
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Retinal Cone Photoreceptor Cells - physiology | Dark Adaptation - physiology | Heterotrimeric GTP-Binding Proteins - metabolism | Carps | Vision, Ocular - physiology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cyclic GMP - metabolism | Retinal Cone Photoreceptor Cells - enzymology | Retinal Rod Photoreceptor Cells - physiology | Retinal Rod Photoreceptor Cells - enzymology | Transducin - metabolism | Adaptation, Ocular - physiology | Enzyme Activation - physiology | Index Medicus | Heterotrimeric G-proteins | Phototransduction | Signal Transduction | Cones | Transducin | Photoreceptors | Retina | Rods | Phosphodiesterases | cGMP Phosphodiesterase
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8. Full Text Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling
by Tsang, Stephen H and Woodruff, Michael L and Lin, Chyuan-Sheng and Jacobson, Barry D and Naumann, Matthew C and Hsu, Chun Wei and Davis, Richard J and Cilluffo, Marianne C and Chen, Jeannie and Fain, Gordon L
Cellular signalling, ISSN 0898-6568, 01/2012, Volume 24, Issue 1, pp. 181 - 188
Rod | Vision | Photoreceptor | G-protein | Retina | Transduction | Phosphodiesterase | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sequence Deletion | Retina - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Membrane Potentials - radiation effects | Retinal Rod Photoreceptor Cells - metabolism | Light | Female | Mice, Inbred DBA | Eye Proteins - antagonists & inhibitors | Retinal Rod Photoreceptor Cells - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Signal Transduction | Retinal Degeneration - genetics | Mice, Inbred C57BL | Mice, Transgenic | 1-Methyl-3-isobutylxanthine - pharmacology | Algorithms | Animals | Eye Proteins - metabolism | Mice | Kinetics | Retinal Degeneration - pathology | Retina - pathology | Index Medicus | vision | retina | rod | transduction | photoreceptor | phosphodiesterase
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9. Full Text Structural Characterization of the Rod cGMP Phosphodiesterase 6
by Goc, Anna and Chami, Mohamed and Lodowski, David T and Bosshart, Patrick and Moiseenkova-Bell, Vera and Baehr, Wolfgang and Engel, Andreas and Palczewski, Krzysztof
Journal of molecular biology, ISSN 0022-2836, 08/2010, Volume 401, Issue 3, pp. 363 - 373
3D electron microscopy | photoreceptor cells | vision | phototransduction | phosphodiesterase 6 | Phosphodiesterase 6 | Phototransduction | Photoreceptor cells | Vision | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Prenylation | Microscopy, Electron, Transmission | Protein Subunits | Catalytic Domain | Models, Molecular | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Peptide Fragments - chemistry | Animals | Cattle | Cyclic GMP | Protein Conformation | Cyclic Nucleotide Phosphodiesterases, Type 6 - isolation & purification | Rod Cell Outer Segment - enzymology | Glutathione transferase | Chemical properties | Index Medicus
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10. Full Text Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase β-subunit gene: Involvement of multiple response elements
by Lerner, Leonid E and Gribanova, Yekaterina E and Ji, Ming and Knox, Barry E and Farber, Debora B
The Journal of biological chemistry, ISSN 0021-9258, 09/2001, Volume 276, Issue 37, pp. 34999 - 35007
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Xenopus | Promoter Regions, Genetic | Receptors, Interleukin - physiology | Transcription Factors - physiology | Response Elements | Sp4 Transcription Factor | 3',5'-Cyclic-GMP Phosphodiesterases - genetics | Humans | Interleukin-11 Receptor alpha Subunit | Transcriptional Activation | Receptors, Interleukin-11 | Phosphoric Diester Hydrolases | Animals | Transfection | Retinal Rod Photoreceptor Cells - enzymology | Female | Transcription, Genetic | Cyclic Nucleotide Phosphodiesterases, Type 6 | HeLa Cells | Sp1 Transcription Factor - physiology | cyclic GMP phosphodiesterase | transgenic frogs | Sp4 protein | beta -PDE gene | retinoblastoma cells | Nr1 protein | Index Medicus
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11. Full Text Molecular organization of bovine rod cGMP-phosphodiesterase 6
by Tcheudji, Jacques F.Kameni and Lebeau, Luc and Virmaux, Noëlle and Maftei, Carmen G and Cote, Rick H and Lugnier, Claire and Schultz, Patrick
Journal of molecular biology, ISSN 0022-2836, 2001, Volume 310, Issue 4, pp. 781 - 791
PDE6 | PDE5 | electron microscopy | immunoelectron microscopy | image analysis | Immunoelectron microscopy | Image analysis | Electron microscopy | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Subunits | Catalytic Domain | Phosphoric Diester Hydrolases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | 3',5'-Cyclic-GMP Phosphodiesterases - isolation & purification | Phosphoric Diester Hydrolases - ultrastructure | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | Blood Platelets - enzymology | Microscopy, Electron | Microscopy, Immunoelectron | Phosphoric Diester Hydrolases - chemistry | Phosphoric Diester Hydrolases - isolation & purification | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Animals | Cattle | Protein Structure, Quaternary | Retinal Rod Photoreceptor Cells - enzymology | 3',5'-Cyclic-GMP Phosphodiesterases - ultrastructure | Cyclic Nucleotide Phosphodiesterases, Type 6 | Index Medicus | Life Sciences
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12. Full Text Autosomal-Recessive Early-Onset Retinitis Pigmentosa Caused by a Mutation in PDE6G, the Gene Encoding the Gamma Subunit of Rod cGMP Phosphodiesterase
by Dvir, Liron and Srour, Gassoub and Abu-Ras, Rasmi and Miller, Benjamin and Shalev, Stavit A and Ben-Yosef, Tamar
American journal of human genetics, ISSN 0002-9297, 2010, Volume 87, Issue 2, pp. 258 - 264
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Retinopathies | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Ophthalmology | Genes, Recessive - genetics | Humans | Child, Preschool | Molecular Sequence Data | Retinitis Pigmentosa - epidemiology | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Mutation - genetics | Homozygote | Retinitis Pigmentosa - enzymology | DNA Mutational Analysis | Israel - epidemiology | Pedigree | Base Sequence | RNA Splicing - genetics | Adolescent | Age of Onset | Retinal Rod Photoreceptor Cells - enzymology | Family | Female | Child | Fundus Oculi | Retinal Rod Photoreceptor Cells - pathology | Protein Subunits - genetics | Retinitis pigmentosa | Physiological aspects | Photoreceptors | Genetic aspects | Chemical properties | Purine nucleotides | Research | Phosphodiesterases | Structure | Arabs | Retina | Eye diseases | Mutation | Genes | Genomics | Index Medicus | Report
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