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molecular sequence data (204) 204
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genetic structures (182) 182
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transducin (178) 178
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neurosciences (174) 174
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research (138) 138
rod cell outer segment - metabolism (136) 136
female (132) 132
transducin - metabolism (127) 127
rhodopsin - metabolism (124) 124
retinitis pigmentosa (121) 121
retinal degeneration - genetics (119) 119
cgmp-phosphodiesterase (116) 116
rod cell outer segment - enzymology (116) 116
base sequence (115) 115
cell biology (115) 115
alpha-subunit (114) 114
mice, inbred c57bl (114) 114
genetics & heredity (113) 113
outer segments (113) 113
retina - metabolism (113) 113
multidisciplinary sciences (111) 111
rod cgmp-phosphodiesterase (111) 111
cyclic gmp - metabolism (110) 110
disease models, animal (110) 110
retinitis-pigmentosa (109) 109
signal transduction (109) 109
phosphodiesterase (108) 108
retinal rod photoreceptor cells - metabolism (107) 107
eye proteins - genetics (104) 104
phosphorylation (103) 103
electroretinography (101) 101
photoreceptor (101) 101
analysis (99) 99
article (99) 99
physiological aspects (98) 98
retinitis pigmentosa - genetics (97) 97
eye diseases (95) 95
cyclic nucleotide phosphodiesterases, type 6 (91) 91
rods (91) 91
3',5'-cyclic-gmp phosphodiesterases - genetics (88) 88
gene expression (86) 86
gene (84) 84
research article (84) 84
retinal rod photoreceptor cells - physiology (84) 84
eye proteins - metabolism (82) 82
retinal rod photoreceptor cells - enzymology (82) 82
vision, ocular - physiology (82) 82
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photoreceptor cells - metabolism (81) 81
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binding sites (76) 76
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recessive retinitis-pigmentosa (74) 74
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mice, transgenic (70) 70
genes (69) 69
leber congenital amaurosis (69) 69
activation (68) 68
calcium - metabolism (67) 67
biochemistry (66) 66
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protein binding (65) 65
photoreceptor cells - enzymology (64) 64
macromolecular substances (63) 63
mouse (63) 63
phosphoric diester hydrolases - metabolism (63) 63
apoptosis (62) 62
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Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 7245 - 10
Activation of cGMP phosphodiesterase (PDE) by activated transducin alpha subunit (T alpha*) is a necessary step to generate a light response in vertebrate... 
MECHANISM | ROD OUTER SEGMENT | KINETICS | MULTIDISCIPLINARY SCIENCES | PARAMETERS | G-PROTEIN | CYCLIC-GMP PHOSPHODIESTERASE | Trapping | Cyclic GMP | Transducin | Photoreceptors | Rods | Kinases | Binding sites | Phosphodiesterase | Catalytic subunits
Journal Article
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2001, Volume 310, Issue 4, pp. 781 - 791
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2011, Volume 15, Issue 8, pp. 1778 - 1787
In vertebrate rods, dark and light conditions produce changes in guanosine 3′,5′‐cyclic monophosphate (cGMP) and calcium (Ca 2+ ) levels, which are regulated... 
a mouse line carrying a missense mutation in | PDE, cGMP‐phosphodiesterase | gene therapy | H620Q | Pde6b | cGMP, guanosine 3′,5′‐cyclic monophosphate | CNGA1, cGMP‐gated cation channels | GNAT1, guanine nucleotide‐binding protein G(t) subunit alpha‐1 | (GUCY2e), (GUCY2f) guanylate cyclases 2e and 2f | ROS, rod outer segments | ERG, electroretinogram | shRNA, short hairpin RNA | lentivirus | Pde6b(H620Q), a mouse line carrying a missense mutation in Pde6b | CALCIUM-CHANNEL BLOCKER | EQUIVALENT-LIGHT HYPOTHESIS | MEDICINE, RESEARCH & EXPERIMENTAL | PDE, cGMP-phosphodiesterase | CNGA1, cGMP-gated cation channels | INHERITED RETINAL DEGENERATION | D-CIS-DILTIAZEM | MEDIATED GENE-TRANSFER | CELL BIOLOGY | RD MOUSE | IN-VIVO | GAMMA-SUBUNIT | LEBERS CONGENITAL AMAUROSIS | BETA-SUBUNIT | GNAT1, guanine nucleotide-binding protein G(t) subunit alpha-1 | cGMP, guanosine 3 ',5 '-cyclic monophosphate | Retina - metabolism | Calcium - metabolism | Humans | Molecular Sequence Data | Immunoblotting | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Sodium - metabolism | RNA Interference | Base Sequence | Light | Female | Retinitis Pigmentosa - physiopathology | Cyclic Nucleotide-Gated Cation Channels - metabolism | Disease Models, Animal | Electroretinography | Retina - radiation effects | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Cell Survival | Mice, Inbred C57BL | Retina - physiopathology | Cyclic Nucleotide-Gated Cation Channels - genetics | Receptors, Cell Surface - metabolism | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Guanylate Cyclase - metabolism | Mice, Knockout | Animals | Cyclic GMP - metabolism | Guanylate Cyclase - genetics | Mice | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Receptors, Cell Surface - genetics | Survival analysis | T cell receptors | Calcium | Sodium | Rodents | Index Medicus | Pde6bH620Q, a mouse line carrying a missense mutation in Pde6b | cGMP, guanosine 3′,5′-cyclic monophosphate
Journal Article
Journal Article
Journal Article
Mechanisms of Development, ISSN 0925-4773, 2008, Volume 125, Issue 11, pp. 932 - 946
In mammals, the blockade of the phototransduction cascade causes loss of vision and, in some cases, degeneration of photoreceptors. However, the molecular... 
cGMP phosphodiesterase 6 | Phototransduction | Cone | Rod | Photoreceptor | Mutant | Zebrafish | Retina | Degeneration | Proliferation | RETINAL DEGENERATION | VISUAL TRANSDUCTION | ALPHA-SUBUNIT | RECESSIVE RETINITIS-PIGMENTOSA | TELEOST RETINA | DEVELOPMENTAL BIOLOGY | ROD PHOSPHODIESTERASE | BEHAVIORAL SCREEN | BINDING-SITES | BETA-SUBUNIT | STATIONARY NIGHT BLINDNESS
Journal Article