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PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53662
This study was designed to investigate the potentially protective effects of glycyrrhetinic acid (GA) and the role of transcription factor nuclear... 
MONOAMINE-OXIDASE | RAT-LIVER | OXIDATIVE STRESS | REACTIVE OXYGEN | LIPID-PEROXIDATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | MOUSE-LIVER | HEPATITIS-C | EXTRACELLULAR-SUPEROXIDE-DISMUTASE | FREE-RADICALS | Fluorocarbons - toxicity | Liver - pathology | Liver - enzymology | Antioxidants - metabolism | Male | RNA, Messenger - metabolism | Biphenyl Compounds - metabolism | Liver Cirrhosis - chemically induced | Glycyrrhetinic Acid - pharmacology | Liver - drug effects | Ferrous Compounds - pharmacology | Cytoprotection - drug effects | Lipid Peroxidation - drug effects | Liver Cirrhosis - metabolism | NF-E2-Related Factor 2 - genetics | Liver Cirrhosis - genetics | Liver - metabolism | Picrates - metabolism | RNA, Messenger - genetics | Up-Regulation - drug effects | Animals | Ascorbic Acid - pharmacology | Liver Cirrhosis - pathology | Mice | Oxidative Stress - drug effects | Chronic Disease | Antioxidants | Enzymes | Liver diseases | Monoamine oxidase | RNA | Liver | Carbon tetrachloride | Fibrosis | Lipid peroxidation | Oxidative stress | Ascorbic acid | Arsenic | Genomics | Genes | Superoxide dismutase | Research | Catalase | Rodents | Hepatology | Peroxidase | Glutathione | Peroxidation | Glutathione peroxidase | Translocation | Free radicals | Superoxide | Inflammation | Mammals | Gene expression | Amine oxidase (flavin-containing) | Nuclear transport | Nodules | Signaling | Acids | Pharmacy | Infiltration | Laboratory animals | Bile
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 12/2017, Volume 44, Issue 12, pp. 1180 - 1191
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85318
Hepatocarcinogenesis commonly involves the gradual progression from hepatitis to fibrosis and cirrhosis, and ultimately to hepatocellular carcinoma (HCC).... 
TRANSGENIC ZEBRAFISH | IN-VITRO | B-VIRUS X | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | LIVER-SPECIFIC EXPRESSION | GROWTH-FACTOR | HUMAN HEPATOCELLULAR-CARCINOMA | HEPATITIS-B | MYC EXPRESSION | Endothelin-1 - antagonists & inhibitors | Cell Proliferation | Fatty Liver - pathology | Humans | Fatty Liver - complications | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Liver Neoplasms - etiology | Carcinoma, Hepatocellular - genetics | HEK293 Cells | Liver Cirrhosis - metabolism | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - etiology | Proto-Oncogene Proteins c-akt - metabolism | Liver Cirrhosis - genetics | Fatty Liver - genetics | Gene Expression | Fatty Liver - metabolism | Liver Neoplasms - genetics | Unfolded Protein Response - genetics | Endothelin-1 - genetics | Endothelin-1 - metabolism | Liver Cirrhosis - complications | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Zebrafish | Phosphatidylinositol 3-Kinases - genetics | Animals | Cell Cycle | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Liver Cirrhosis - pathology | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Zebrafish Proteins - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Cell Movement | Genetically modified animals | Animal genetic engineering | Endothelin | T cells | Glycogen | Liver cirrhosis | Cell proliferation | Cell culture | Liver | Genes | Xenotransplantation | Hyperplasia | Hepatocellular carcinoma | AKT protein | Transgenic fish | Hepatitis | Liver cancer | Cell growth | Protein folding | Rodents | Xenografts | Cell cycle | Endothelin 1 | Gene expression | Ribonucleic acid--RNA | Bile duct | 1-Phosphatidylinositol 3-kinase | Steatosis | Cirrhosis | Inhibitors | Hepatocytes | Fibrosis | Cell migration | RNA | Ribonucleic acid
Journal Article
Hepatology, ISSN 0270-9139, 12/2017, Volume 66, Issue 6, pp. 1934 - 1951
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155163
Although non-alcoholic and alcoholic fatty liver disease have been intensively studied, concerning pathophysiological mechanisms are still incompletely... 
CONFERS SUSCEPTIBILITY | INDUCED HEPATIC STEATOSIS | BINDING-PROTEIN P62/IGF2BP2-2 | HIGH-FAT DIET | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | NONALCOHOLIC STEATOHEPATITIS | FREE-CHOLESTEROL | DENK BODY FORMATION | INDUCED OBESITY | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Species Specificity | Diet, High-Fat - adverse effects | Ethanol - administration & dosage | Non-alcoholic Fatty Liver Disease - etiology | Male | Mice, 129 Strain | Fatty Liver, Alcoholic - metabolism | Fatty Acids, Nonesterified - metabolism | Fatty Liver, Alcoholic - genetics | Subcutaneous Fat - metabolism | Dietary Fats - administration & dosage | Fatty Liver, Alcoholic - pathology | Weight Gain | Disease Models, Animal | Biomarkers - metabolism | Liver Function Tests | Disease Susceptibility | Non-alcoholic Fatty Liver Disease - genetics | Fatty Liver, Alcoholic - etiology | Liver - metabolism | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Cholesterol - metabolism | Mice, Inbred Strains | Subcutaneous Fat - pathology | Aspartate Aminotransferases - metabolism | Triglycerides - metabolism | Animals | Mice | Alanine Transaminase - metabolism | Fatty liver | Diet | Physiological aspects | Development and progression | Models | Research | Risk factors | Biotechnology | Animal models | Dehydrogenases | Liver | Lipids | Alcohol | Biochemistry | Biology | High fat diet | Fatty acid composition | Rodents | Hepatology | Physiology | Carbohydrates | Liver diseases | Ethanol | Inflammation | Metabolism | Gene expression | Fatty acids | Feeding | Steatosis | Nutrition research | Pathology | Natural products | Pharmacy | Insulin resistance | Pharmaceuticals
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92925
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it... 
RAT HEPATIC LIPOCYTES | HEPATOCELLULAR-CARCINOMA | SMOOTH-MUSCLE ACTIN | MULTIDISCIPLINARY SCIENCES | PDGFR-ALPHA | IN-VIVO | CARBON-TETRACHLORIDE | EXPRESSION | PULMONARY-FIBROSIS | TRANSGENIC MICE | BETA | Liver - pathology | Humans | Gene Expression Regulation, Neoplastic | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Liver - drug effects | Carcinoma, Hepatocellular - genetics | Liver Cirrhosis - metabolism | Chemical and Drug Induced Liver Injury - pathology | Liver Cirrhosis - genetics | Cell Line | Liver Cirrhosis - drug therapy | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Liver Neoplasms - genetics | Liver - metabolism | RNA, Messenger - genetics | Gene Dosage | Chemical and Drug Induced Liver Injury - genetics | Animals | Chemical and Drug Induced Liver Injury - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Alleles | Liver Cirrhosis - pathology | Mice | Fluorescence | Liver cancer | Platelet-derived growth factor | Health aspects | Liver cirrhosis | Fibrosis | Liver | Carbon tetrachloride | Smooth muscle | Activation | Adipocytes | Kinases | Risk factors | Signal transduction | Cell growth | Rodents | Surgery | Growth factors | Stellate cells | Liver diseases | Health risks | Pathology | Cirrhosis | Signaling | Injury prevention | Pulmonary fibrosis | Hepatocytes | Collagen | Green fluorescent protein | Laboratory animals
Journal Article
Liver International, ISSN 1478-3223, 01/2018, Volume 38, Issue 1, pp. 102 - 112
Background & Aims Recent studies suggest that heparins reduce liver fibrosis and the risk of decompensation of liver disease. Here, we evaluated the effects of... 
liver fibrosis | portal hypertension | rat | anticoagulation | VEIN THROMBOSIS | LOW-MOLECULAR-WEIGHT | MODEL | HEPARIN | ENDOTHELIAL-CELLS | NITRIC-OXIDE | VASCULAR-RESISTANCE | CARBON-TETRACHLORIDE | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Hypertension, Portal - physiopathology | Male | Bacterial Translocation - drug effects | Liver Cirrhosis, Experimental - physiopathology | Microcirculation - drug effects | Hypertension, Portal - prevention & control | Portal Pressure - drug effects | Anticoagulants - toxicity | Liver Cirrhosis, Experimental - prevention & control | Liver - drug effects | Liver Circulation - drug effects | Liver Cirrhosis, Experimental - pathology | Chemical and Drug Induced Liver Injury - blood | Chemical and Drug Induced Liver Injury - pathology | Enoxaparin - toxicity | Chemical and Drug Induced Liver Injury - prevention & control | Endothelial Cells - metabolism | Hypertension, Portal - pathology | Liver - metabolism | Inflammation Mediators - blood | Biomarkers - blood | Chemical and Drug Induced Liver Injury - physiopathology | Enoxaparin - pharmacology | Rats, Sprague-Dawley | Liver Cirrhosis, Experimental - blood | Animals | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Hypertension, Portal - blood | Endothelial Cells - pathology | Endothelial Cells - drug effects | Liver | Carbon tetrachloride | Portal hypertension | Fibrosis | Anticoagulants (Medicine) | Gene expression | Liver cirrhosis | Endothelium | Splenomegaly | Interleukin 6 | Rodents | Bacteria | Heparins | Hypertension | Translocation | Anticoagulants | Liver diseases | Health risks | Rats | CCL4 protein | Disease control | Survival | Bile duct | Inhalation | Cirrhosis | Respiration | Ascites | Bile
Journal Article