X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
rolipram (486) 486
animals (477) 477
humans (271) 271
male (263) 263
rats (234) 234
phosphodiesterase inhibitors - pharmacology (228) 228
index medicus (220) 220
rolipram - pharmacology (208) 208
cyclic nucleotide phosphodiesterases, type 4 (188) 188
pharmacology & pharmacy (187) 187
cyclic amp - metabolism (178) 178
neurosciences (164) 164
mice (162) 162
phosphodiesterase (152) 152
3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors (130) 130
camp (123) 123
3',5'-cyclic-amp phosphodiesterases - metabolism (118) 118
biochemistry & molecular biology (117) 117
pyrrolidinones - pharmacology (107) 107
phosphorylation (96) 96
cyclic amp (92) 92
binding (84) 84
expression (83) 83
female (83) 83
dose-response relationship, drug (81) 81
brain (79) 79
rats, sprague-dawley (79) 79
camp-specific phosphodiesterase (76) 76
cell biology (74) 74
inhibitors (70) 70
cyclic nucleotide phosphodiesterases, type 4 - metabolism (69) 69
binding sites (67) 67
pde4 (67) 67
asthma (64) 64
phosphodiesterase 4 inhibitors - pharmacology (62) 62
cells, cultured (61) 61
cyclic-amp (61) 61
colforsin - pharmacology (58) 58
chemistry, medicinal (57) 57
cyclic-nucleotide phosphodiesterases (55) 55
proteins (55) 55
in vitro techniques (53) 53
kinetics (52) 52
guinea pigs (51) 51
signal transduction (51) 51
structure-activity relationship (51) 51
cell line (50) 50
memory (50) 50
3',5'-cyclic-amp phosphodiesterases - genetics (49) 49
activation (49) 49
rats, wistar (49) 49
analysis (48) 48
brain - metabolism (48) 48
element-binding protein (48) 48
protein binding (48) 48
disease models, animal (47) 47
inflammation (47) 47
mice, inbred c57bl (47) 47
phosphodiesterase inhibitors - metabolism (47) 47
kinases (46) 46
psychiatry (46) 46
rodents (46) 46
article (45) 45
cells (44) 44
phosphoric diester hydrolases - metabolism (44) 44
cyclic amp-dependent protein kinases - metabolism (43) 43
isoenzymes - metabolism (43) 43
phosphodiesterase inhibitors - therapeutic use (43) 43
rat-brain (43) 43
cyclic amp response element-binding protein - metabolism (42) 42
molecular sequence data (42) 42
multidisciplinary sciences (42) 42
phosphodiesterase inhibitors (42) 42
signal transduction - drug effects (42) 42
brain - drug effects (41) 41
pyrrolidinones - metabolism (41) 41
cyclic-nucleotide phosphodiesterase (39) 39
hippocampus (39) 39
research article (39) 39
in-vitro (38) 38
long-term potentiation (38) 38
amp-specific phosphodiesterase (37) 37
time factors (37) 37
guinea-pig (36) 36
inhibition (36) 36
medicine (36) 36
protein-kinase (36) 36
research (36) 36
enzyme inhibitors - pharmacology (35) 35
hippocampus - metabolism (35) 35
phosphodiesterase inhibitors - chemistry (35) 35
hippocampus - drug effects (34) 34
amino acid sequence (33) 33
brain - enzymology (33) 33
creb (33) 33
messenger-rna (33) 33
physiology (33) 33
rat (33) 33
chemistry, organic (32) 32
cyclic adenylic acid (32) 32
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal Article
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 361
Journal Article
Investigational New Drugs, ISSN 0167-6997, 10/2008, Volume 26, Issue 5, pp. 417 - 424
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2002, Volume 22, Issue 9, pp. 3673 - 3682
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2008, Volume 35, Issue 4, pp. 515 - 521
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2006, Volume 398, Issue 1, pp. 23 - 36
The cAMP-specific phosphodiesterase PDE4D5 can interact with the signalling scaffold proteins RACK (receptors for activated C-kinase) 1 and beta-arrestin.... 
adrenergic receptor | RACK1 | cAMP-dependent protein kinase (PKA) | β-arrestin | cAMP-specific phosphodiesterase (PDE) | RECRUITMENT | MEMBRANE SUPPORTS | KINASE-A | AMP | MECHANISM | beta-arrestin | BIOCHEMISTRY & MOLECULAR BIOLOGY | beta-adrenergic receptor | INHIBITION | TERMINAL REGION | SELECTIVITY | ASSOCIATION | RNA, Small Interfering - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Cyclic Nucleotide Phosphodiesterases, Type 3 | Cercopithecus aethiops | Molecular Sequence Data | Extracellular Signal-Regulated MAP Kinases - metabolism | Peptide Library | Neoplasm Proteins - metabolism | Arrestins - metabolism | Receptors for Activated C Kinase | Phosphorylation - drug effects | Binding Sites | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Catalytic Domain - genetics | Models, Molecular | Receptors, Cell Surface - metabolism | Enzyme Activation - drug effects | Receptors, Adrenergic, beta-2 - metabolism | Phosphoric Diester Hydrolases - chemistry | Protein Interaction Mapping | Animals | beta-Arrestins | Isoproterenol - pharmacology | Protein Binding | COS Cells | GTP-Binding Proteins - metabolism | GFP, green fluorescent protein | GST, glutathione S-transferase | HEK, human embryonic kidney | RAID, RACK-binding site | siRNA, small interfering RNA | SEC, siRNA expression cassette | PDE, phosphodiesterase | ERK, extracellular-signal-regulated kinase | GRK2, G-protein-coupled-receptor kinase 2 | rolipram, 4-[3-(cyclopentoxyl)-4-methoxyphenyl]-2-pyrrolidone | RACK, receptors for activated C-kinase | GPCR, G-protein-coupled receptor | β2-adrenergic receptor | PDE4, rolipram-inhibited cAMP specific PDE | PKA, protein kinase A | β2AR, β2-adrenergic receptor
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2007, Volume 34, Issue 1, pp. 71 - 77
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2002, Volume 22, Issue 22, pp. 9868 - 9876
Journal Article
Life Sciences, ISSN 0024-3205, 2006, Volume 79, Issue 4, pp. 356 - 364
Journal Article
Annals of Neurology, ISSN 0364-5134, 11/2004, Volume 56, Issue 5, pp. 611 - 623
Perinatal hypoxic‐ischemic (HI) brain injury is a major cause of permanent neurological dysfunction in children. An approach to study the treatment of neonatal... 
CREB | MEMORY | CAROTID-ARTERY LIGATION | TOLERANCE | TRANSCRIPTION | NEURONS | HYPOXIC-ISCHEMIC INJURY | IMMATURE RATS | BLOOD-FLOW | CEREBRAL-ISCHEMIA | NEUROSCIENCES | CLINICAL NEUROLOGY | Brain-Derived Neurotrophic Factor - genetics | Phosphorylation | Cerebrovascular Circulation - physiology | Fetal Hypoxia - prevention & control | Male | Hypoxia-Ischemia, Brain - prevention & control | Fetal Hypoxia - metabolism | Ligation - methods | Behavior, Animal | Dose-Response Relationship, Drug | Ischemic Preconditioning - methods | RNA, Messenger - biosynthesis | Time Factors | Reverse Transcriptase Polymerase Chain Reaction - methods | Female | Brain-Derived Neurotrophic Factor - metabolism | Rolipram - pharmacology | Hypoxia-Ischemia, Brain - metabolism | Disease Models, Animal | Animals, Newborn | Blotting, Western - methods | Fetal Hypoxia - enzymology | Maze Learning - physiology | Colforsin - pharmacology | Oligodeoxyribonucleotides, Antisense - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Rats | Autoradiography - methods | Organ Size - physiology | Hypoxia-Ischemia, Brain - enzymology | Functional Laterality | Reaction Time - physiology | Serine - metabolism | Immunohistochemistry - methods | Animals | Analysis of Variance | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Carotid Stenosis | Enzyme Activation
Journal Article