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roxadustat fg-4592 (52) 52
index medicus (48) 48
anemia (42) 42
humans (30) 30
chronic kidney disease (29) 29
hypoxia (24) 24
urology & nephrology (24) 24
erythropoietin (22) 22
pharmacology & pharmacy (19) 19
anemia - drug therapy (17) 17
epoetin-alpha (17) 17
roxadustat (17) 17
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animals (14) 14
erythropoiesis-stimulating agents (14) 14
renal insufficiency, chronic - complications (13) 13
glycine - analogs & derivatives (12) 12
prolyl hydroxylase inhibitor (12) 12
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health aspects (10) 10
hepcidin (10) 10
iron (10) 10
analysis (9) 9
ckd (9) 9
dialysis (9) 9
erythropoiesis (9) 9
fg-4592 (9) 9
hematinics - therapeutic use (9) 9
hemodialysis-patients (9) 9
hypoxia-inducible factors (9) 9
glycine - therapeutic use (8) 8
hemoglobin (8) 8
hydroxylase inhibitor gsk1278863 (8) 8
inflammation (8) 8
isoquinolines - therapeutic use (8) 8
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clinical trials (7) 7
hemodialysis (7) 7
hif-1-alpha (7) 7
hypoxia-inducible factor 1 - metabolism (7) 7
hypoxia-inducible factor-proline dioxygenases - antagonists & inhibitors (7) 7
mice (7) 7
peripheral vascular disease (7) 7
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anemia - complications (6) 6
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hif (6) 6
hydroxylase (6) 6
kidneys (6) 6
nephrology (6) 6
physiological aspects (6) 6
recombinant-human-erythropoietin (6) 6
renal insufficiency, chronic - metabolism (6) 6
transcription factors (6) 6
adult (5) 5
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gene expression (5) 5
hydroxylases (5) 5
hypoxia-inducible factor 1, alpha subunit - metabolism (5) 5
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prolyl-hydroxylase inhibitors - therapeutic use (4) 4
regulates hepcidin (4) 4
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American Journal of Kidney Diseases, ISSN 0272-6386, 2016, Volume 67, Issue 6, pp. 912 - 924
Journal Article
Journal Article
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2016, Volume 38, Issue 4, pp. 918 - 928
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2019, Volume 79, Issue 10, pp. 2564 - 2579
We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology... 
HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | HIF PROLYL HYDROXYLASES | GENE | ONCOLOGY | ANEMIA | HIF-1-ALPHA | HYPOXIA | SUPPRESSION | ROXADUSTAT FG-4592 | EXPRESSION | HIF1-ALPHA
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 09/2016, Volume 36, Issue 9, pp. 1782 - 1790
Objective Atherosclerotic lesions contain hypoxic areas, but the pathophysiological importance of hypoxia is unknown. Hypoxia-inducible factor-1 (HIF-1) is a... 
atherosclerosis | hypoxia | NITRIC-OXIDE SYNTHASE | MURINE ATHEROSCLEROSIS | apoptosis | macrophage | ALPHA | DEFICIENT MICE | PLAQUES | FOAM CELLS | ROXADUSTAT FG-4592 | INFLAMMATION | hypoxia-inducible factor 1 | TUMOR-SUPPRESSOR PROTEIN | PERIPHERAL VASCULAR DISEASE | HIF-1-ALPHA | HEMATOLOGY
Journal Article
Journal Article
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, ISSN 0931-0509, 10/2018, Volume 33, Issue 10, pp. 1690 - 1698
Journal Article
Plastic and Reconstructive Surgery, ISSN 0032-1052, 04/2019, Volume 143, Issue 4, pp. 769e - 779e
BACKGROUND:The hypoxia-inducible factor (HIF) pathway, regulated by prolyl hydroxylase, is central to tissue adaptation to ischemia. The authors tested whether... 
SURVIVAL | SURGERY | PRETREATMENT | ANGIOGENESIS | DIMETHYLOXALYLGLYCINE | ANEMIA | INDUCTION | ROXADUSTAT FG-4592 | DELAY | HYPOXIA-INDUCIBLE FACTORS | PROTECTS | Care and treatment | Enzyme inhibitors | Ischemia | Skin-grafting | Models | Hydroxylases | Health aspects | Testing | Necrosis
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 01/2018, Volume 27, Issue 1, pp. 125 - 133
Introduction: Anaemia is one of the hallmarks of advanced chronic kidney disease (CKD); it correlates with a lower quality of life and increased cardiovascular... 
erythropoiesis stimulating agents | chronic kidney disease | hepcidin | Anaemia | HIF | prolyl-hydroxylases domain | roxadustat | TRANSCRIPTION FACTORS | HOMEOSTASIS | FG-4592 | ERYTHROPOIETIN PRODUCTION | ERYTHROCYTOSIS | HYPOXIA-INDUCIBLE FACTORS | RESPONSES | INFLAMMATION | PROLYL-HYDROXYLASE | REGULATES HEPCIDIN | PHARMACOLOGY & PHARMACY
Journal Article