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Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2018, Volume 14, Issue 5, p. e1007312
During neural circuit formation, most axons are guided to complex environments, coming into contact with multiple potential synaptic partners. However, it is... 
TRANSSYNAPTIC INTERACTION | NERVOUS-SYSTEM | ADHESION | COMPLEX | CAENORHABDITIS-ELEGANS | LAR-RPTPS | TUMOR-SUPPRESSOR GENES | EXCITATORY SYNAPSES | GENETICS & HEREDITY | C-ELEGANS | CELL-SURFACE INTERACTIONS | Locomotion - genetics | Synaptic Transmission - physiology | Synaptic Transmission - genetics | Caenorhabditis elegans Proteins - metabolism | Green Fluorescent Proteins - genetics | Synapses - genetics | Receptor-Like Protein Tyrosine Phosphatases - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Larva - genetics | Sensory Receptor Cells - metabolism | Green Fluorescent Proteins - metabolism | Caenorhabditis elegans - metabolism | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Synapses - physiology | Larva - metabolism | Receptor-Like Protein Tyrosine Phosphatases - metabolism | Caenorhabditis elegans - embryology | Cell Adhesion Molecules, Neuronal - genetics | Microscopy, Confocal | Animals | Interneurons - metabolism | Mutation | Locomotion - physiology | Recognition (Psychology) | Caenorhabditis elegans Proteins - genetics | Tyrosine | Nervous system diseases | Neural circuitry | Phosphatases | Neurons | Animal behavior | Fluorescence | Phenols | Neurophysiology | Physiological aspects | Protein kinases | Visualization | Interneurons | Synaptogenesis | Axonogenesis | Circuits | Phosphatase | Neurological diseases | Proteins | Genetic analysis | Sensory neurons | Nematodes | Axon guidance | DCC protein | Supervision | Cancer | Protein-tyrosine-phosphatase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 43, pp. 37137 - 37146
Journal Article
Schizophrenia Research, ISSN 0920-9964, 04/2019, Volume 206, pp. 75 - 81
The contribution of both common and rare risk variants to the genetic architecture of schizophrenia (SZ) has been documented in genome-wide association... 
INHIBITION | DE-NOVO MUTATIONS | RPTP-ALPHA | ALIGNMENT | PHOSPHORYLATION | PSYCHIATRY | OF-FUNCTION VARIANTS | GENES | FRAMEWORK | RISK | ASSOCIATION | Tyrosine | Phosphatases | Lubrication and lubricants | Genomics | Phenols | Schizophrenia | Family | Nucleotide sequencing | Glutamate | DNA sequencing
Journal Article
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 01/2018, Volume 144, pp. 318 - 329
A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These... 
Drug addiction | CHEMISTRY, MEDICINAL | MOLECULE | Molecular dynamics | PLEIOTROPHIN OVEREXPRESSION | ANAPLASTIC LYMPHOMA KINASE | SWISS-MODEL | GROWTH-FACTOR MIDKINE | GENETIC INACTIVATION | Synthesis | PTPRZ1 | NEURITE OUTGROWTH | SIGNALING PATHWAY | CNS disorders | BINDING | ZETA/RPTP-BETA
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2018, Volume 38, Issue 23, pp. 5399 - 5414
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory... 
RPTPσ | Cathepsin B | CSPG | DRG | Axon regeneration | Protease | RPTP sigma | FUNCTIONAL RECOVERY | cathepsin B | ALZHEIMERS-DISEASE | axon regeneration | REGENERATION FAILURE | NEUROSCIENCES | protease | MATRIX METALLOPROTEINASES | PTP-SIGMA | LYSOSOMAL PROTEOLYSIS | IN-VITRO | PLASMINOGEN-ACTIVATOR | SPINAL-CORD-INJURY | EXTRACELLULAR-MATRIX
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2015, Volume 35, Issue 35, pp. 12162 - 12171
Multiple sclerosis (MS) is a progressive neurological disorder associated with myelin destruction and neurodegeneration. Oligodendrocyte precursor cells (OPCs)... 
Multiple sclerosis | PTPRZ | Oligodendrocyte | Tyrosine phosphorylation | Remyelination | Pleiotrophin | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SUBSTRATE-TRAPPING SYSTEM | STEM-CELLS | WHITE-MATTER | multiple sclerosis | oligodendrocyte | P190 RHOGAP | NEUROSCIENCES | pleiotrophin | GROWTH-FACTOR MIDKINE | MULTIPLE-SCLEROSIS | IN-VIVO | tyrosine phosphorylation | ZETA RPTP-BETA | ZETA/RPTP-BETA | remyelination | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - deficiency | Demyelinating Diseases - metabolism | Tumor Suppressor Protein p53 - genetics | Stem Cells | Cell Differentiation - genetics | Oligodendroglia - drug effects | Oligodendroglia - physiology | Amyloid beta-Protein Precursor - metabolism | Demyelinating Diseases - chemically induced | Disease Models, Animal | Cuprizone - toxicity | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - genetics | Cytokines - metabolism | Myelin Basic Protein - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Proteoglycans - metabolism | Mice, Transgenic | Antigens - metabolism | Tumor Suppressor Protein p53 - deficiency | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Carrier Proteins - metabolism | Cell Differentiation - drug effects | Corpus Callosum - pathology | Mice
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2016, Volume 291, Issue 41, pp. 21335 - 21349
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e48797
Background: Fyn tyrosine kinase-mediated down-regulation of Rho activity through activation of p190RhoGAP is crucial for oligodendrocyte differentiation and... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SUBSTRATE-TRAPPING SYSTEM | MULTIPLE-SCLEROSIS | MULTIDISCIPLINARY SCIENCES | MOLECULE HB-GAM | 6B4 PROTEOGLYCAN/PHOSPHACAN | CENTRAL-NERVOUS-SYSTEM | CHONDROITIN SULFATE PROTEOGLYCAN | LONG-TERM POTENTIATION | DEFICIENT MICE | ZETA/RPTP-BETA | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - physiology | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - genetics | Genetic Predisposition to Disease | Phosphorylation | Spinal Cord - metabolism | Myelin-Oligodendrocyte Glycoprotein | Genotype | Myelin Sheath - metabolism | Cell Differentiation - genetics | Animals | Oligodendroglia - physiology | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Oligodendroglia - enzymology | Mice | Encephalomyelitis, Autoimmune, Experimental - genetics | Oligodendroglia - cytology | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism | Tyrosine | Physiological aspects | Phenols | Phosphatases | T cells | Myelin proteins | Spinal cord | Neurosciences | Multiple sclerosis | Oligodendrocyte-myelin glycoprotein | Encephalomyelitis | Central nervous system | Neurobiology | Nervous system | Lymphocytes T | Biology | Dephosphorylation | Kinases | Macrophages | Phosphatase | Myelin basic protein | Proteins | Demyelination | Rodents | Oligodendrocytes | Down-regulation | Protein-tyrosine kinase | Genotypes | Fyn protein | Immunization | Demyelinating diseases | Myelin | Glycoprotein | Cultures | Substantia alba | Experimental allergic encephalomyelitis | Substrates | Microglia | Myelination | Ligands | In vivo methods and tests | Autoimmune diseases | Differentiation | Protein-tyrosine-phosphatase
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2018, Volume 38, Issue 39, pp. 8345 - 8363
Eph receptors play pivotal roles in the axon guidance of retinal ganglion cells (RGCs) at the optic chiasm and the establishment of the topographic... 
R3 RPTPs | Topographic maps | PTPRJ | C-Abl | Eph receptors | PTPRO | OPTIC CHIASM | MULTIPLE MECHANISMS | c-Abl | VISUAL-SYSTEM | CANCER | NEUROSCIENCES | FAMILY | BRANCH EXTENSION | IN-VITRO | MAP DEVELOPMENT | GROWTH | GRADIENTS | topographic maps
Journal Article