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The Journal of biological chemistry, ISSN 0021-9258, 05/2019, Volume 294, Issue 28, pp. 10846 - 10862
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 41, pp. E6290 - E6297
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 01/2013, Volume 112, Issue 1, pp. 128 - 139
RATIONALE:Cardiac myocyte hypertrophy is the main compensatory response to chronic stress on the heart. p90 ribosomal S6 kinase (RSK) family members are... 
PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | ACTIVATED PROTEIN-KINASE | compartmentalization | PHOSPHORYLATION | MUSCLE | DILATED CARDIOMYOPATHY | EXTRACELLULAR SIGNAL | RSK | MAKAP-BETA | IN-VIVO | concentric | PERIPHERAL VASCULAR DISEASE | p90 ribosomal S6 kinase | cardiac hypertrophy | INHIBITOR | HEMATOLOGY | Immunoprecipitation | Humans | Cercopithecus aethiops | Ribosomal Protein S6 Kinases, 90-kDa - deficiency | Cardiomegaly - pathology | Male | Isoproterenol | Myocytes, Cardiac - enzymology | A Kinase Anchor Proteins - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Transfection | RNA Interference | HEK293 Cells | Female | Protein Interaction Domains and Motifs | Binding Sites | A Kinase Anchor Proteins - metabolism | Disease Models, Animal | Animals, Newborn | Transduction, Genetic | Signal Transduction | Mice, Inbred C57BL | Rats | Genotype | Cardiomegaly - enzymology | Rats, Sprague-Dawley | Mice, Knockout | Protein Interaction Mapping | Myocytes, Cardiac - pathology | Phenotype | Animals | Cardiomegaly - prevention & control | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Cardiomegaly - chemically induced | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cardiomegaly - genetics | COS Cells | Index Medicus | Compartmentalization | mAKAP
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2012, Volume 30, Issue 7, pp. 1338 - 1348
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12886 - 12895
Background: S100B is overexpressed in malignant melanoma and contributes to cancer progression. Results: The S100B-RSK complex was found to be Ca2+-dependent,... 
WILD-TYPE | S100 Proteins | ACTIVATION | Calcium | BIOCHEMISTRY & MOLECULAR BIOLOGY | Melanoma | RECEPTOR | RSK | BINDING PROTEIN | P53 | FAMILY | Calcium Binding Proteins | MAP Kinases (MAPKs) | MAGNETIC-RESONANCE-SPECTROSCOPY | Cancer | ERK | GLYCATION END-PRODUCTS | S100B(BETA-BETA)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 48, pp. 41171 - 41182
Open reading frame 45 (ORF45) of Kaposi sarcoma-associated herpesvirus (KSHV) causes sustained activation of p90 ribosomal 56 kinase (RSK), which is crucial... 
ENTRY SITE | HELICASE ACTIVITY | BACTERIAL ARTIFICIAL CHROMOSOME | FACTOR EIF-4B | INFECTED CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTOR | PRIMARY EFFUSION LYMPHOMA | GENE-EXPRESSION | TUBEROUS SCLEROSIS | VACCINIA VIRUS | Gene Expression Regulation, Viral - drug effects | Protein Biosynthesis | TOR Serine-Threonine Kinases - metabolism | Humans | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | Immediate-Early Proteins - metabolism | Phosphorylation - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Herpesvirus 8, Human - physiology | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Gene Expression Regulation, Viral - physiology | Virus Replication - drug effects | Sirolimus - pharmacology | Immediate-Early Proteins - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Mutation | Virus Replication - physiology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Gene Regulation | Virus | MAP Kinases (MAPKs) | eIF4B | Phosphorylation | Tegument | Translation Regulation | Kaposi Sarcoma Associated Herpesvirus (KSHV) | p90 Ribosomal S6 Kinase (RSK) | ORF45 | Translation Initiation Factors
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2006, Volume 113, Issue 21, pp. 2516 - 2523
Background - Pharmacological and genetic studies indicate that the Na+-H+ exchanger isoform 1 (NHE1) plays a critical role in myocardial ischemia and... 
Heart | Reperfusion | Ischemia | Ribosomal S6 kinases | exchanger | NHE1 | CARDIAC & CARDIOVASCULAR SYSTEMS | Na+-H+ exchanger | MYOCARDIAL-INFARCTION | P90(RSK) | PHOSPHORYLATION | HEARTS | ISOFORM-1 | MAP KINASES | heart | ischemia | CARIPORIDE | RAF-1 | PERIPHERAL VASCULAR DISEASE | ribosomal S6 kinases | ACTIVATED PROTEIN-KINASES | reperfusion
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 7/2016, Volume 418, Issue 1, pp. 21 - 29
p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various... 
Life Sciences | Biochemistry, general | Cell proliferation | Glycogen synthase kinase-3β | p90 Ribosomal S6 kinase | Osteopontin | Medical Biochemistry | Oncology | Anti-apoptosis | Lung adenocarcinoma | Cardiology | Cell migration | APOPTOSIS | ACTIVATION | METASTASIS | PROTEIN | ISOFORMS |