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rsk (181) 181
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Biochemical Journal, ISSN 0264-6021, 12/2005, Volume 392, Issue 2, pp. 249 - 261
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a... 
Receptor tyrosine kinase | Signalling network | Systems biology | Extracellular-signal-regulated kinase (ERK) | Computational modelling | Mitogen-activated protein kinase (MAPK) | systems biology | EARLY GENE-PRODUCTS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | BIOCHEMICAL NETWORKS | QUANTITATIVE-ANALYSIS | ERK ACTIVATION | extracellular-signal-regulated kinase (ERK) | GROWTH-FACTOR RECEPTOR | COMPLEX-FORMATION | signalling network | DUAL PHOSPHORYLATION | computational modelling | receptor tyrosine kinase | SIGNAL-REGULATED KINASE | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Receptor Protein-Tyrosine Kinases - metabolism | Models, Biological | Computer Simulation | MAP Kinase Signaling System | MEK, MAPK | ODE, ordinary differential equation | MAPKK | MP1, MEK partner 1 | NGF, nerve growth factor | MKP, MAPK phosphatase | Review | MCA, Metabolic Control Analysis | ERK kinase | ERK, extracellular-signal-regulated kinase | PKA, cAMP-activated protein kinase | Shc, Src homology and collagen homology | STAT5, signal transduction and activator of transcription 5 | RSK, ribosomal S6 kinase | FBA, Flux Balance Analysis | SOS, son of sevenless | CD domain, common docking domain | MKKK, MAPKK kinase | PLCγ, phospholipase Cγ | EGF(R), epidermal growth factor (receptor) | FGF, fibroblast growth factor | MKK, MAPK kinase | SBML, Systems Biology Markup Language | JIP, JNK (c-Jun N-terminal kinase)-interacting protein | PDE4, phosphodiesterase 4 | KSR, kinase suppressor of Ras | MAPKKK | Grb2, growth-factor-receptor-bound protein 2 | RTK, receptor tyrosine kinase | GAP, GTPase-activating protein | PDGF, platelet-derived growth factor | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 347 - 357
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 04/2005, Volume 387, pp. 507 - 517
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2015, Volume 27, Issue 9, pp. 1720 - 1730
The transduction pathway mediating the inhibitory effect that TRH exerts on r-ERG channels has been thoroughly studied in GH 3 rat pituitary cells but some... 
ERK (extracellular-signal-regulated kinase) | Phosphorylation | RSK (ribosomal S6 kinase) | Phosphoproteomics | Kv (voltage-gated potassium channels) | Thyrotropin-releasing hormone
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 491 - 501
MSK 1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2)... 
Precursor ion scanning MS | cAMP-response-element-binding protein (CREB) | p90 ribosomal S6 kinase (RSK) | p38 | Extracellular-signal-regulated kinase (ERK) | Mitogen-activated protein kinase (MAPK) | precursor ion scanning MS | ACTIVATED PROTEIN-KINASE | STRESS-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | BINDING PROTEIN | DOCKING SITE | extracellular-signal-regulated kinase (ERK) | TUMOR-NECROSIS-FACTOR | LYSOPHOSPHATIDIC ACID | EMBRYONIC STEM-CELLS | HYDROPHOBIC MOTIF PHOSPHORYLATION | MAPKAP KINASE-2 | RIBOSOMAL S6 KINASE | Amino Acid Sequence | Cell Line | Phosphorylation | Humans | Molecular Sequence Data | Phosphoserine - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Sequence Alignment | Mutagenesis | Mass Spectrometry | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Conserved Sequence | Protein Binding | Enzyme Activation | Phosphoserine - chemistry | Mitogen-Activated Protein Kinases - metabolism | 2, MAPK | RSK, p90 ribosomal S6 kinase | MSK, mitogen- and stress-activated kinase | AGC-type kinases, protein kinase A | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase C-family kinases | LC, liquid chromatography | ERK kinase 1 | MNK, MAPK-integrating kinase | PKI, protein kinase A inhibitor | protein kinase G | CREB, cAMP-response-element-binding | GST, glutathione S-transferase | MS, tandem MS | ATF, activating transcription factor | MAPKAPK2 | MEK1 | MRM, multiple reaction monitoring | 3, MAPK-activated protein kinase-2 | MAPK, mitogen-activated protein kinase
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2000, Volume 5, Issue 3, pp. 513 - 522
Here we report the identification of a novel PMA-inducible IκB kinase complex, distinct from the well-characterized high-molecular weight IκB kinase complex... 
UBIQUITINATION | ACTIVATION | SITE-SPECIFIC PHOSPHORYLATION | PP90(RSK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | DEGRADATION | RIBOSOMAL S6 KINASE | IDENTIFICATION | PROTEINS | BETA | CELL BIOLOGY
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 03/2014, Volume 24, Issue 6, pp. 1592 - 1596
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to... 
SURVIVAL | ACTIVATION | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | HTS | Benzoxazole | CHEMISTRY, ORGANIC | RSK | EPITHELIAL-CELLS | Kinase | PATHWAY | GROWTH | RIBOSOMAL S6 KINASE | Heterocycle | HEMATOPOIETIC TRANSFORMATION
Journal Article
Journal Article
Journal Article
BIOCHEMICAL SOCIETY TRANSACTIONS, ISSN 0300-5127, 02/2013, Volume 41, Issue 1, pp. 124 - 126
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2006, Volume 393, Issue 3, pp. 715 - 724
Nur77 is a nuclear orphan receptor that is able to activate transcription independently of exogenous ligand, and has also been shown to promote apoptosis on... 
Ribosomal S6 kinase (RSK) | Protein kinase B (PKB) | Nur77 | Phosphorylation | Nuclear orphan receptor | Apoptosis | DNA-BINDING DOMAIN | ACTIVATION | RECEPTOR NGFI-B | ORPHAN NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GENE NUR77 | apoptosis | nuclear orphan receptor | NERVE GROWTH-FACTOR | MEMBRANE DEPOLARIZATION | protein kinase B (PKB) | phosphorylation | TRANSCRIPTIONAL REGULATION | ribosomal S6 kinase (RSK) | Cell Line | Receptors, Steroid - metabolism | Mitogens - pharmacology | Ribosomal Protein S6 Kinases - metabolism | Humans | Nuclear Receptor Subfamily 4, Group A, Member 1 | Nuclear Receptor Subfamily 4, Group A, Member 2 | 14-3-3 Proteins - metabolism | DNA-Binding Proteins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Thyroid Hormone - metabolism | Transcription Factors - metabolism | Animals | Protein Binding | Mice | Mutation | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Ribosomal Protein S6 Kinases, 90-kDa | Receptors, Cytoplasmic and Nuclear - metabolism | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | RXR, retinoid X receptor | NGF, nerve growth factor | MSK, mitogen- and stress-activated kinase | CREB, cAMP-response-element-binding protein | EST, expressed sequence tag | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | ES, embryonic stem | RSK, ribosomal S6 kinase | DMEM, Dulbecco's modified Eagle's medium | GSK3, glycogen synthase kinase-3 | IGF, insulin-like growth factor | NBRE, NGF-induced B factor response element | DIG, digoxigenin | HEK-293 cells, human embryonic kidney 293 cells | GST, glutathione S-transferase | ORF, open reading frame | NurRE, Nur response element | HA, haemagglutinin | bFGF, basic fibroblast growth factor | MAPK, mitogen-activated protein kinase | PKA, protein kinase A
Journal Article
Journal Article