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Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 500, Issue 3, pp. 810 - 816
Ribosomal S6 protein kinase 4 (RSK4) was known as a novel tumor suppressor gene, and the tumor necrosis factor receptor-associated factor 4 (TRAF4) was linked... 
NF-κB | Breast cancer | AKT | TRAF4 | RSK4 | Lentivirus | Immunohistochemistry | RNA | Analysis | Liver | Bone morphogenetic proteins | Metastasis | Transforming growth factors | Protein kinases | Index Medicus
Journal Article
by Hu, C and Dai, J and Lin, X and Meng, Y and Liang, H
CANCER MANAGEMENT AND RESEARCH, ISSN 1179-1322, 2020, Volume 12, pp. 611 - 619
Purpose: Gastric cancer is one of the most common cancers with high mortality. Emerging evidences show that ribosomal s6 kinase4 (RSK4) may be an anti-oncogene... 
gastric cancer | proliferation | invasion | ONCOLOGY | PHOSPHORYLATION | migration | apoptosis | RIBOSOMAL S6 KINASE | RSK4 | EXPRESSION | rsk4
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2551 - 2563
The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | PROTEIN-KINASE | DUAL PI3K/MTOR INHIBITOR | RIBOSOMAL S6 KINASE | FUNCTIONAL-CHARACTERIZATION | RSK4 | PHASE-I | EXPRESSION | RNAI SCREEN | Physiological aspects | Breast cancer | Genetic aspects | Cellular signal transduction | Research | Drug therapy | Drug resistance | Risk factors | Proteins | Medical research | Kinases | Tumors
Journal Article
OncoTargets and therapy, ISSN 1178-6930, 2019, Volume 12, pp. 5907 - 5916
It's well documented that estrogen plays a vital role in breast cancer progression, but the molecular mechanisms underlying it still remains incompletely... 
Immunohistochemistry | Sulfites | Methyltransferases | Genes | Phenols | Development and progression | Breast cancer | Genetic transcription | Methylation | Estradiol | Apoptosis | DNMT3B | estrogen | RSK4 | ER positive | methylation
Journal Article
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2017, Volume 10, Issue 12, pp. 11405 - 11414
The clinical significance of p90-kDa ribosomal S6 kinase (RSK) family members in lung adenocarcinoma (LUAD) is unknown. The aim of this study was to analyze... 
Immunohistochemistry | Lung adenocarcinoma | RSK family | RSK4 | TCGA | CELLS | METASTASIS | ISOFORMS | PATHOLOGY | CANCER | SCREEN | ONCOLOGY | RIBOSOMAL S6 KINASE | immunohistochemistry
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 09/2017, Volume 40, Issue 3, pp. 883 - 890
Breast cancer is the most frequently diagnosed cancer in both more and less economically developed countries and remains the leading cause of cancer-related... 
DNA methylation | Extracellular signal-regulated kinase | AKT | Breast cancer | Tumorigenicity | RSK4 | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | extracellular signal-regulated kinase | STATISTICS | breast cancer | INDUCED SENESCENCE | TUMORS | tumorigenicity | GENES | RESISTANCE | RIBOSOMAL S6 KINASE
Journal Article
Medical Oncology, ISSN 1357-0560, 2/2016, Volume 33, Issue 2, pp. 1 - 8
Survival rate in ovarian cancer depends on the stage of the disease. RSK4, which has been considered as a tumor suppressor factor, controls cells invasion due... 
Pathology | RPS6KA6 | Medicine & Public Health | Hematology | Ribosomal S6 kinase 4 | Vorinostat | Oncology | Internal Medicine | RSK4 | Cisplatin | Ovarian cancer | INDUCED SENESCENCE | X-LINKED GENES | BREAST-CANCER | ARREST | HYDROXAMIC ACID SAHA | ONCOLOGY | GROWTH | INHIBITOR | Antimitotic agents | RNA | Drug therapy | Antineoplastic agents
Journal Article
Journal Article
ONCOLOGY LETTERS, ISSN 1792-1074, 09/2019, Volume 18, Issue 3, pp. 2853 - 2860
Adenocarcinomas exhibit great heterogeneity, with many genetic and epigenetic alterations. The Kelch domain-containing protein 7B (KLHDC7B) has recently been... 
Kelch domain-containing protein 7B | BYPASS | DNA METHYLATION | epigenetic | MARKER | PATTERNS | PROLIFERATION | biomarker | RSK4 | ONCOLOGY | methylation | cancer | SENESCENCE | breast
Journal Article
International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, 10/2016, Volume 9, Issue 10, pp. 19324 - 19334
Paclitaxel (PTX) has shown encouraging activity in the treatment of advanced gastric cancer. However, the fact that more than half of GC patients respond... 
AKT | RSK4 | Gastric cancer | Paclitaxel | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | paclitaxel | CELLS | ADENOCARCINOMA | KINASE | PROLIFERATION | CHEMOTHERAPY | PATHWAY | NF-KAPPA-B | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
Medical Oncology, ISSN 1357-0560, 1/2014, Volume 31, Issue 1, pp. 1 - 8
Breast cancer is one of the most common cancers and is the second leading cause of cancer-related death in women worldwide. Ribosomal s6 kinase4 (RSK4) is a... 
Pathology | Medicine & Public Health | Hematology | Oncology | Internal Medicine | Breast cancer | Ribosomal s6 kinase4 RSK4 | Methylation | HYPERMETHYLATION | DNA METHYLATION | 5-AZA-2'-DEOXYCYTIDINE | ONCOLOGY | KINASE | X-LINKED GENES | FAMILY | Sulfites | RNA | Analysis | Development and progression | Health aspects | Index Medicus
Journal Article
Journal Article
World Journal of Surgical Oncology, ISSN 1477-7819, 12/2018, Volume 16, Issue 1, pp. 240 - 9
Journal Article
by Sun, Y and Cao, S and Yang, M and Wu, S and Wang, Z and Lin, X and Song, X and Liao, D.J
Oncogene, ISSN 0950-9232, 04/2013, Volume 32, Issue 14, pp. 1794 - 1810
The RPS6KA6 gene encodes the p90 ribosomal S6 kinase-4 (RSK4) that is still largely uncharacterized. In this study we identified a new RSK4 transcription... 
PRS6KA6 | breast cancer | pancreatic cancer | alternative splicing | RSK4 | TRANSLATIONAL REGULATION | CYCLIN D1 | TRANSGENIC MOUSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | C-MYC | OVARIAN-CANCER | INDUCED SENESCENCE | X-LINKED GENES | CELL BIOLOGY | BREAST-CANCER | MESSENGER-RNA | ONCOLOGY | GENETICS & HEREDITY | Cyclin D1 - metabolism | RNA, Small Interfering - genetics | Cell Proliferation | Immunoprecipitation | Alternative Splicing | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Immunoenzyme Techniques | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Neoplasms - genetics | Base Sequence | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacology | Female | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | RNA, Messenger - genetics | Exons - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Proto-Oncogene Proteins c-myc - metabolism | Sequence Homology, Nucleic Acid | Blotting, Western | Neoplasms - drug therapy | Azacitidine - pharmacology | Animals | Cell Cycle | Cyclin D1 - genetics | Protein Isoforms | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Transcription Initiation Site | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms - pathology | Apoptosis | Genetic aspects | Genetic transcription | Research | Ribosomal proteins | RNA splicing | Cancer | Proteins | Pancreatic cancer | Oncology | Breast cancer | Kinases | Gene expression | Tumors
Journal Article