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Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, pp. 11733 - 11733
Journal Article
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 2, pp. 261 - 272
Journal Article
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2004, Volume 24, Issue 7, pp. 2890 - 2904
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 14, pp. 2826 - 2835
Journal Article
Blood, ISSN 0006-4971, 05/2016, Volume 127, Issue 20, pp. 2451 - 2459
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 500, Issue 7460, pp. 93 - 97
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 8, pp. 1829 - 1841
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein... 
acute myeloid leukemia | chromatin | epigenetic regulation | integrated analysis of high-throughput data | RUNX1/ETO | AML1-ETO | STEM-CELLS | ACUTE MYELOGENOUS LEUKEMIA | SELF-RENEWAL | ACUTE MYELOID-LEUKEMIA | HEMATOPOIESIS | ONCOLOGY | IN-VIVO | FUSION PROTEIN | GENE-EXPRESSION | DIFFERENTIATION | HEMATOLOGY | Chromatin - metabolism | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Transcriptional Activation | CCAAT-Binding Factor - genetics | Gene Expression Profiling | RNA Polymerase II - metabolism | Cell Differentiation - genetics | CCAAT-Binding Factor - metabolism | Acetylation | Binding Sites | Chromosomes, Human, Pair 21 | Proto-Oncogene Proteins - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Gene Silencing | Proto-Oncogene Proteins - genetics | Chromosomes, Human, Pair 8 | Transcription Factors - genetics | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Histones - metabolism | Mutation | Chromatin - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Cluster Analysis | Leukemia, Myeloid, Acute - genetics | Physiological aspects | Chromatin | Transcription factors | Research | Gene expression | Cell lines | Index Medicus | ETO | Original | RUNX1
Journal Article
Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6043, pp. 765 - 769
The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional... 
Cell growth | Myeloid leukemia | Leukemia | Genes | REPORTS | Antibodies | Histones | Amino acids | Acetylation | Leukocytes | Cells | DNA-BINDING | DOMAIN | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | T(8/21) | TRANSCRIPTION | FUSION PROTEIN | MYELOID-LEUKEMIA | SELF-RENEWAL | DIFFERENTIATION | INHIBITOR | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Transcriptional Activation | Preleukemia - pathology | E1A-Associated p300 Protein - metabolism | Gene Expression Profiling | Oncogene Proteins, Fusion - chemistry | Core Binding Factor Alpha 2 Subunit - chemistry | E1A-Associated p300 Protein - antagonists & inhibitors | Hematopoietic Stem Cells - physiology | Lysine - metabolism | Protein Interaction Domains and Motifs | Tumor Cells, Cultured | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Mutant Proteins - metabolism | Fetal Blood - cytology | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Animals | Cell Transformation, Neoplastic | Hematopoietic Stem Cells - cytology | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Genetic aspects | Research | Lysine | Health aspects | Cancer cells | Proteins | Biochemistry | Cellular biology | Chromosomes | Rope | Mathematical models | Transformations | Leukemias | Blood | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2733 - 18
ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces... 
TRANSFORMATION | CELL SELF-RENEWAL | CLONAL HEMATOPOIESIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | FREQUENT MUTATION | EXPRESSION | MYELODYSPLASTIC SYNDROMES | CHRONIC MYELOMONOCYTIC LEUKEMIA | TUMOR-SUPPRESSOR BAP1 | MONOCYTE DIFFERENTIATION | Whole-Body Irradiation | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid - genetics | Interferon Regulatory Factors - metabolism | Male | Carcinogenesis - metabolism | Leukemia, Myeloid - pathology | Ubiquitination | Bone Marrow - metabolism | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | HEK293 Cells | Ubiquitin Thiolesterase - metabolism | Female | RUNX1 Translocation Partner 1 Protein - genetics | Leukemia, Myeloid - mortality | RUNX1 Translocation Partner 1 Protein - metabolism | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Mice, Inbred C57BL | Carcinogenesis - genetics | Interferon Regulatory Factors - genetics | Repressor Proteins - genetics | Gene Expression Regulation, Leukemic | Ubiquitin Thiolesterase - genetics | Gene Editing | Homeodomain Proteins - genetics | Carcinogenesis - pathology | Animals | Leukemia, Myeloid - metabolism | Bone Marrow - pathology | CRISPR-Cas Systems | Survival Analysis | Mice | HeLa Cells | Mutation | Core Binding Factor Alpha 2 Subunit - genetics | Myeloid leukemia | Leukemia | Runx1 protein | Gene expression | Progenitor cells | Neoplasms | Cells (biology) | Stem cells | Tumor suppressor genes | HOXA gene | Catalysis | Tumors | Index Medicus
Journal Article