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runx1/eto (7) 7
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Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2019, Volume 117, pp. 109113 - 109113
The fusion gene AML1-ETO initially dysregulates various cell cycle molecules in t(8;21) acute myeloid leukemia. Aurora kinases have shown great promise in... 
Aurora kinase | Barasertib | Alisertib | AML-ETO | Acute myeloid leukemia | AML | MEDICINE, RESEARCH & EXPERIMENTAL | NETWORK | EFFICACY | DNA-DAMAGE | SELF-RENEWAL | PROLIFERATION | AZD1152 | MLN8237 | GENOME-WIDE | PHARMACOLOGY & PHARMACY | RUNX1/ETO | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 8, pp. 1829 - 1841
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein... 
acute myeloid leukemia | chromatin | epigenetic regulation | integrated analysis of high-throughput data | RUNX1/ETO | AML1-ETO | STEM-CELLS | ACUTE MYELOGENOUS LEUKEMIA | SELF-RENEWAL | ACUTE MYELOID-LEUKEMIA | HEMATOPOIESIS | ONCOLOGY | IN-VIVO | FUSION PROTEIN | GENE-EXPRESSION | DIFFERENTIATION | HEMATOLOGY | Chromatin - metabolism | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Transcriptional Activation | CCAAT-Binding Factor - genetics | Gene Expression Profiling | RNA Polymerase II - metabolism | Cell Differentiation - genetics | CCAAT-Binding Factor - metabolism | Acetylation | Binding Sites | Chromosomes, Human, Pair 21 | Proto-Oncogene Proteins - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Gene Silencing | Proto-Oncogene Proteins - genetics | Chromosomes, Human, Pair 8 | Transcription Factors - genetics | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Histones - metabolism | Mutation | Chromatin - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Cluster Analysis | Leukemia, Myeloid, Acute - genetics | Physiological aspects | Chromatin | Transcription factors | Research | Gene expression | Cell lines | Index Medicus | ETO | Original | RUNX1
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2018, Volume 34, Issue 4, pp. 626 - 642.e8
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 03/2018, Volume 119, Issue 3, pp. 2750 - 2762
Journal Article
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2013, Volume 4, pp. 254 - 254
Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription... 
Epigenetics | Stem/progenitor cell expansion | RUNX1/ETO | Leukemia | HSPC | epigenetics | stem/progenitor cell expansion
Journal Article
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