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Bioorganic Chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 413 - 419
Retinoid X receptor alpha (RXRα), a central member of the nuclear receptor superfamily and a key regulator of many signal transduction pathways, has been an... 
Virtual screening | Conformational selection | RXRα | RXRα tetramer | RXRα ligands | RXR alpha tetramer | DESIGN | PROTEIN | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPORT | CHEMISTRY, ORGANIC | CANCER | RXR alpha ligands | DYNAMICS | RETINOID-X-RECEPTOR | LIGAND | SULINDAC | RXR alpha | BINDING
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 562 - 575
Nuclear receptor RXRα plays an important role in many biological and pathological processes. The nongenomic action of RXRα is implicated in many cancers.... 
RXRα modulator | RXRα | Bioisostere | Anticancer activity | PI3K/AKT pathway | CHEMISTRY, MEDICINAL | RXR alpha modulator | X-RECEPTOR-ALPHA | SULINDAC | RXR alpha | CANCER | BINDING | MODULATION | Index Medicus
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 12/2016, Volume 17, Issue 6, pp. 663 - 675
Retinoid X receptors (RXRs) occupy a central position within the nuclear receptor superfamily. They not only function as important transcriptional factors but... 
RXRα modulators | RXRα | PI3K | NSAID | Rexinoid | Inflammation | Nuclear receptors | Nongenomic action | Apoptosis | TRXRα | tRXRα | CHEMISTRY, MEDICINAL | tRXR alpha | 9-CIS-RETINOIC ACID | CANCER-THERAPY | RXR alpha modulators | RETINOBENZOIC ACIDS | STRUCTURAL BASIS | DOCOSAHEXAENOIC ACID | BIOLOGICAL EVALUATION | LEUKEMIA-CELLS | RETINOID-X-RECEPTOR | TNF-ALPHA | RXR alpha
Journal Article
Journal of Virology, ISSN 0022-538X, 04/2018, Volume 92, Issue 8, p. e01771-17
Multiple steps of the life cycle of hepatitis B virus (HBV) are known to be coupled to hepatic metabolism. However, the details of involvement of the hepatic... 
RXRα | Inhibition | Arachidonic acid | HBV | NTCP | arachidonic acid | CHOLESTEROL | SCHISTOSOMA-MANSONI | TRANSCRIPTION | inhibition | HEPATOCYTE RXR-ALPHA | ARACHIDONIC-ACID | IN-VITRO | VIROLOGY | METABOLISM | BIOSYNTHESIS | RXR alpha | NUCLEAR FACTORS | EPIDEMIOLOGY | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2019, Volume 593, Issue 2, pp. 242 - 250
1‐[(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)amino]benzotriazole‐5‐carboxylic acid (CBt‐PMN), a partial agonist of retinoid X receptor ( RXR ),... 
molecular dynamics simulations | crystal structure | fragment molecular orbital theory | partial agonist | RXR | biochemical analysis | RXRα | ACID | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING DOMAIN | CELL BIOLOGY | BIOPHYSICS | COACTIVATOR PEPTIDE | DYNAMICS | RXR alpha
Journal Article
Annals of Diagnostic Pathology, ISSN 1092-9134, 06/2018, Volume 34, pp. 110 - 115
Esophageal carcinoma (EC) is one of the most aggressive type cancers and dysregulation of retinoid X receptor α (RXRα) involves various tumors. However, the... 
Esophageal carcinoma | Biomarker | RXRα | Prognosis | Expression | BREAST-CANCER | GAMMA | CANCER STATISTICS | PATHOLOGY | RXR alpha | RXR-ALPHA | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2019, Volume 193, pp. 105421 - 105421
Increasing evidence has shown that one of the major neurosteroids, estradiol, has potent neuroprotective actions. We have reported that estradiol synthesis was... 
Neuroprotection | CYP19 | Estradiol | RXR | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 26, pp. E6039 - E6047
Leptin expression decreases after fat loss and is increased when obesity develops, and its proper quantitative regulation is essential for the homeostatic... 
PPARγ/RXRα | Lipid sensing | Adipose tissue | Leptin | Weak binding | ACTIVATED RECEPTOR-GAMMA | ADIPOCYTES | CHROMATIN | lipid sensing | MULTIDISCIPLINARY SCIENCES | adipose tissue | PPAR gamma/RXR alpha | leptin | NUCLEAR RECEPTOR | weak binding | OB GENE-EXPRESSION | IN-VIVO | FAT | PROMOTER | TRANSCRIPTION FACTOR | MOUSE OBESE GENE | Index Medicus | Biological Sciences | RXRα | PNAS Plus | PPARγ
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2004, Volume 11, Issue 2, pp. S126 - S143
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2014, Volume 5, Issue 7, pp. 736 - 741
Retinoid X receptor-alpha (RXR alpha) is implicated in the regulation of many biological processes and also represents a unique intracellular target for... 
coregulator-binding site | nongenomic actions | RXRα | RXRα antagonist | virtual screening | DESIGN | CHEMISTRY, MEDICINAL | MODULATORS | RETINOID-X-RECEPTOR | DISRUPTORS | RXR alpha | CANCER | DISCOVERY | RXRa antagonist
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2019, Volume 10, Issue 2, pp. 203 - 208
As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell... 
Inflammation | Nuclear receptors | Neurodegeneration | RXR | REXINOIDS | CHEMISTRY, MEDICINAL | ACID | PREVENTION | BEXAROTENE | OPPORTUNITIES | RXR AGONIST | CANCER
Journal Article
TRENDS IN BIOCHEMICAL SCIENCES, ISSN 0968-0004, 01/2019, Volume 44, Issue 1, pp. 2 - 6
Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate... 
COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETERODIMER | RXR
Journal Article
FASEB Journal, ISSN 0892-6638, 11/2018, Volume 32, Issue 11, pp. 5990 - 6001
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of... 
RXRα | Polyunsaturated fatty acids | PPARγ | 5-hydroxymethylcytosine | METHYLATION | 5-METHYLCYTOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | polyunsaturated fatty acids | TET PROTEINS | RXR | CELL BIOLOGY | CANCER GROWTH | PATHOGENESIS | EPIGENETICS | PPAR | BIOLOGY | POLYUNSATURATED FATTY-ACIDS | TUMOR-SUPPRESSOR | PROSTAGLANDIN E-3
Journal Article
Journal Article