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guanine nucleotide exchange factors - genetics (9) 9
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Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 6912 - 6922
The activity of Rac in leukocytes is essential for immunity. However, its role in NK cell-mediated anti-microbial signaling remains unclear. In this study, we... 
IMMUNITY | Cellular signaling | Src | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALS | RECEPTOR | adhesion | Rac (Rac GTPase) | PHOSPHOINOSITIDE 3-KINASE | PLC-GAMMA | fungi | Cryptococcus | natural killer cells (NK cells) | phosphatidylinositide 3-kinase (PI 3-kinase) | PROTEINS | SMALL GTPASES | POLARIZATION | T-CELLS | LYMPHOCYTES | RNA, Small Interfering - genetics | Cryptococcus neoformans - physiology | Humans | Class Ia Phosphatidylinositol 3-Kinase - immunology | Pyrones - pharmacology | Quinolines - pharmacology | rac GTP-Binding Proteins - antagonists & inhibitors | rac1 GTP-Binding Protein - immunology | rac GTP-Binding Proteins - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Killer Cells, Natural - immunology | Phosphorylation - drug effects | Class Ia Phosphatidylinositol 3-Kinase - genetics | Killer Cells, Natural - microbiology | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Gene Expression Regulation | rac GTP-Binding Proteins - immunology | src-Family Kinases - immunology | Host-Pathogen Interactions | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Killer Cells, Natural - drug effects | Primary Cell Culture | src-Family Kinases - genetics | Cytotoxicity, Immunologic | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Immunology
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2009, Volume 297, Issue 6, pp. 1091 - 1102
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 12/2010, Volume 37, Issue 12, pp. 1147 - 1153
Summary 1. Diallyl disulphide (DADS) has potential as a chemopreventive and therapeutic agent. Previous studies have reported that Ras‐related C3 botulinum... 
diallyl disulphide | Rac2 | leukaemia | NADPH oxidase | reactive oxygen species | Reactive oxygen species | Diallyl disulphide | Leukaemia | CARCINOMA-CELLS | PATHWAYS | TARGET | ACTIVATION | PHYSIOLOGY | INDUCTION | THERAPY | FENRETINIDE-INDUCED APOPTOSIS | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | EXPRESSION | CANCER CHEMOPREVENTION | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | NADPH Oxidases - metabolism | rac GTP-Binding Proteins - biosynthesis | p38 Mitogen-Activated Protein Kinases - biosynthesis | rac GTP-Binding Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-myc - biosynthesis | Flow Cytometry | rac GTP-Binding Proteins - genetics | DNA Fragmentation | Leukemia, Myeloid, Acute - drug therapy | NADPH Oxidases - genetics | Caspase 3 - biosynthesis | Disulfides - pharmacology | NADPH Oxidases - biosynthesis | Transcription Factor AP-1 - biosynthesis | Allyl Compounds - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Up-Regulation - drug effects | rac GTP-Binding Proteins - pharmacology | Cell Line, Tumor | HL-60 Cells | Apoptosis - physiology | Leukemia, Myeloid, Acute - genetics | Oxidases | Fluorescence | RNA | Analysis | Leukemia | Apoptosis
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2015, Volume 466, Issue 3, pp. 431 - 442
Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose... 
RhoG | Cell division control protein 42 (cdc42) | Secretion | Shape change | Thrombosis | Rif | shape change | PHOSPHOLIPASE C-GAMMA-2 | INTEGRIN ALPHABETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIMICROBIAL PEPTIDES | GTP-BINDING PROTEINS | secretion | thrombosis | CELL-MIGRATION | NUCLEOTIDE EXCHANGE FACTOR | FILOPODIUM FORMATION | ACTIN CYTOSKELETON | cell division control protein 42 (Cdc42) | GRANULE SECRETION | Animals | Humans | Platelet Activation - physiology | Platelet Aggregation - physiology | Signal Transduction - physiology | Blood Platelets - enzymology | rho GTP-Binding Proteins - physiology | Blood Platelets - secretion | PAK, P21-activated kinase | ECM, extracellular matrix | VWF, von Willebrand factor | PAR, protease activated receptor | Syk, spleen tyrosine kinase | SNARE, soluble N-ethylmaleimide attachment protein receptors | DOCK, dedicator of cytokinesis | F-actin, filamentous actin | MTSS1, metastasis suppressor protein 1 | 3 complex | AP-MS, affinity-purification mass spectrometry | LAT, linker for activation of T-cells | Cdc42, cell division control protein 42 | IMD, IRSp53 and MIM homology domain | 3, actin related protein 2 | PLC, phospholipase C | TCR, T-cell receptor | Rif, Rho in filopodia (RhoF) | PI3K, phosphoinositide 3-kinase | GDI, guanine nucleotide dissociation inhibitor | ITAM, immunoreceptor tyrosine-based activation motif | Review | ARP2 | WASP, Wiskott–Aldrich syndrome protein | CRP, collagen-related peptide | NSF, N-ethylmaleimide-sensitive factor | PF4, platelet factor-4 | Rho GTPase, Ras homology family GTPase | Rac, Ras-related C3 botulinum toxin substrate | ARHGEF, Rho guanine nucleotide exchange factor | GP, glycoprotein | ELMO, engulfment and cell motility | PKC, protein kinase C | Ena, enabled | MLC, myosin light chain | ROCK, Rho kinase | VAMP, vesicle-associated membrane protein | TRIO, triple functional domain containing protein | GAP, GTPase activating protein | LARG, leukaemia-associated Rho GEF (ARHGEF12) | GEF, guanine nucleotide exchange factor | PREX-1, PI(3,4,5)P3-dependent Rac exchanger 1 protein | VASP, vasodilator-stimulated phosphoprotein | FcR, Fc receptor
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 10, pp. 6408 - 6418
Journal Article
Annals of Anatomy, ISSN 0940-9602, 07/2011, Volume 193, Issue 4, pp. 259 - 266
GTPases function as intracellular, bimolecular switches by adopting different conformational states in response to binding GDP or GTP. Their activation is... 
Branching | Sprouting | Rac | GAP | GEF | Axon | Growth cone | Elongation | Cdc42 | Dendrite | ADULT SENSORY NEURONS | ANATOMY & MORPHOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | NOGO-A | MYELIN-ASSOCIATED GLYCOPROTEIN | ENHANCES AXONAL REGENERATION | GROWTH CONE COLLAPSE | NEURITE GROWTH | MESSENGER-RNA | SIGNALING PATHWAY | PC12 CELLS | Animals | Neuronal Plasticity - physiology | Humans | Neurons - enzymology | Neurons - physiology | Axons - physiology | Cytoskeleton - physiology | rho GTP-Binding Proteins - physiology | Phosphates | Ubiquitin | Sarcoma | Glycogen | Nerve growth factor | Phospholipids | Muscle proteins | Gross domestic product | Purines | Synthesis | Myosin | Fibroblast growth factors | G proteins | Adenylic acid | Protein kinases | GSK-3β, glycogen synthase kinase-3β | PIP, phosphatidylinositol 4,5-bisphosphate | PI3K, phosphatidylinositol-3 kinase | Rho, Ras homologous | GDI, guanine nucleotide dissociation inhibitor | NGF, nerve growth factor | Ras, Rat sarcoma | C3, Clostridium botulinum ribosyltransferase | cAMP, cyclic adenosine monophosphate | Rac interactive binding | SAPK, stress-activated protein kinase | PIP-5kinase, phosphatidylinositol-4 phosphate-5 kinase | Rac, Ras-related C3 botulinum toxin substrate | ROCK, Rho-associated coiled-coil-containing protein kinase | FGF-2, fibroblast growth factor 2 | Smurf, Smad ubiquitination regulatory factor | m-Dia, formin mammalian diaphanous | FAK, focal adhesion kinase | MLC, myosin light chain | PAK, partitioning defective-6 | DRG, dorsal root ganglia | MAP, mitogen-activated protein | LPA, lysophosphatidic acid | Cdc42, cell division control protein 42 homolog | PAR6, p21-activated kinase | ERK, extracellular signal-regulated kinase | GEF, guanine nucleotide exchange factor | NT3, neurotrophin-3 | PKN, protein kinase N | CRIB, Cdc42 | GAP, GTPase-activating protein | JNK, Jun N-terminal kinase | N-WASP, neural Wiskott–Aldrich syndrome protein
Journal Article