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Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1055 - 1062
Bromodomain and extraterminal domain (BET) protein inhibitors are emerging as promising anticancer therapies. The gene encoding the E3 ubiquitin ligase... 
SELECTIVE-INHIBITION | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | ANDROGEN RECEPTOR | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | ENHANCERS | CELL BIOLOGY | RNA-SEQ | BROMODOMAIN INHIBITION | MUTATIONS | BRD4 | Prostatic Neoplasms - metabolism | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Male | Gene Expression Profiling | Molecular Targeted Therapy | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Multiprotein Complexes - metabolism | Prostatic Neoplasms - genetics | Proteasome Endopeptidase Complex - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Triazoles - therapeutic use | Cell Survival | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Azepines - therapeutic use | RNA-Binding Proteins - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Proto-Oncogene Proteins c-akt - drug effects | rac1 GTP-Binding Protein - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Drug resistance | Drug therapy | Prostate cancer | Ubiquitin | Inhibitor drugs | Stabilization | AKT protein | Activation | Biosynthesis | Degradation | Proteins | Ubiquitination | Transcription activation | Bioindicators | Ubiquitin-protein ligase | Binding | Rac1 protein | Tumor cell lines | Gene expression | Cholesterol | Mutants | Inhibitors | Proteasomes | Biomarkers | Bet protein | Prostate | Cancer | Guanosinetriphosphatase
Journal Article
Neuron, ISSN 0896-6273, 09/2013, Volume 79, Issue 6, pp. 1169 - 1182
The gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2016, Volume 291, Issue 9, pp. 4323 - 4333
Invadosomes are actin-rich membrane protrusions that degrade the extracellular matrix to drive tumor cell invasion. Key players in invadosome formation are... 
Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Extracellular Matrix - metabolism | Melanoma - enzymology | Podosomes - enzymology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Lysophosphatidic Acid - agonists | Receptors, Lysophosphatidic Acid - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Endothelins - metabolism | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Podosomes - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Neoplasm Proteins - genetics | Biomarkers - metabolism | Melanoma - metabolism | Recombinant Proteins - metabolism | rac1 GTP-Binding Protein - agonists | rhoA GTP-Binding Protein - antagonists & inhibitors | Recombinant Proteins - genetics | Melanoma - pathology | cdc42 GTP-Binding Protein - agonists | Hydrolysis | Podosomes - pathology | Microscopy, Confocal | Neoplasm Proteins - agonists | cdc42 GTP-Binding Protein - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Extracellular Matrix - pathology | Microscopy, Fluorescence | rac1 GTP-Binding Protein - metabolism | Luminescent Proteins - metabolism | rac1 GTP-Binding Protein - genetics | CDC42 | invadopodia | biosensor | fluorescence resonance energy transfer (FRET) | calcium intracellular release | G protein-coupled receptor (GPCR) | Rho (Rho GTPase) | phosphatidylinositide 3-kinase (PI 3-kinase) | imaging | Rac (Rac GTPase) | Cell Biology
Journal Article
Journal Article
Structure, ISSN 0969-2126, 09/2016, Volume 24, Issue 9, pp. 1499 - 1508
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2017, Volume 474, Issue 7, pp. 1259 - 1272
Active, GTP-bound small GTPases need to be attached to membranes by post-translational lipid modifications in order to process and propagate information in... 
MYRISTOYLATED ARF1 | REGULATOR | GUANINE-NUCLEOTIDE-EXCHANGE | STRUCTURAL BASIS | EFFICIENT ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAB7 GTPASE | RHO-GTPASES | PROTEINS | BINDING | FAMILY | Humans | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | GTPase-Activating Proteins - metabolism | Histidine - metabolism | rhoA GTP-Binding Protein - genetics | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Guanine Nucleotide Exchange Factors - metabolism | ADP-Ribosylation Factor 1 - metabolism | Phosphatidylinositols - metabolism | ADP-Ribosylation Factor 1 - genetics | Legionella pneumophila - chemistry | Phosphatidylinositols - genetics | Recombinant Proteins - metabolism | Gene Expression | Guanine Nucleotide Exchange Factors - genetics | rho GTP-Binding Proteins - genetics | Oligopeptides - genetics | Bacterial Proteins - genetics | Histidine - genetics | Membranes, Artificial | Recombinant Proteins - genetics | Oligopeptides - metabolism | DNA-Binding Proteins - genetics | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Protein Binding | Bacterial Proteins - metabolism | Enzyme Activation | GTPase-Activating Proteins - genetics | rac1 GTP-Binding Protein - metabolism | Protein Isoforms - genetics | rac1 GTP-Binding Protein - genetics
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | sensitive, voltage gated A-type K+ channel | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | subunits of the Ca | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | proprotein convertase subtilisin | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | exin type 6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article