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1. Full Text Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
by Sotiriou, Sotirios K and Kamileri, Irene and Lugli, Natalia and Evangelou, Konstantinos and Da-Ré, Caterina and Huber, Florian and Padayachy, Laura and Tardy, Sebastien and Nicati, Noemie L and Barriot, Samia and Ochs, Fena and Lukas, Jiri and Lukas, Claudia and Gorgoulis, Vassilis G and Scapozza, Leonardo and Halazonetis, Thanos D
Molecular Cell, ISSN 1097-2765, 12/2016, Volume 64, Issue 6, pp. 1127 - 1134
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as... 
RAD52 | cancer | DNA recombination | break-induced replication | DNA replication stress | GENOMIC INSTABILITY | INACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | MECHANISMS | CHECKPOINT | HOMOLOGOUS RECOMBINATION | INHIBITORS | STRESS | TUMORIGENESIS | DAMAGE | CELL BIOLOGY | Genomic Instability | RNA, Small Interfering - genetics | Humans | Nocodazole - pharmacology | Stress, Physiological | Cyclin E - genetics | DNA Breaks, Double-Stranded | Rad52 DNA Repair and Recombination Protein - metabolism | S Phase | Osteosarcoma - metabolism | Adenomatous Polyposis Coli Protein - genetics | Gene Expression | Osteosarcoma - mortality | Recombinational DNA Repair | DNA - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | Mice, Knockout | DNA - genetics | G1 Phase | Rad52 DNA Repair and Recombination Protein - antagonists & inhibitors | Animals | CRISPR-Cas Systems | Survival Analysis | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cyclin E - metabolism | Osteosarcoma - genetics | Adenomatous Polyposis Coli Protein - deficiency | Osteosarcoma - pathology | RNA, Small Interfering - metabolism | Medical colleges | DNA replication | Molecular biology | Genes | DNA | Short
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2. Full Text DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination
by Leizhen Wei and Satoshi Nakajima and Stefanie Böhm and Kara A. Bernstein and Zhiyuan Shen and Michael Tsang and Arthur S. Levine and Li Lan
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. E3495 - E3504
Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are largely unknown. To elucidate these mechanisms, we introduced genome... 
Dna damage | Recombination | CSB | Transcription | RNA polymerase II | COMPLEX | recombination | PROTEIN | transcription | DNA damage | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | PREFERENTIAL REPAIR | CHROMOSOMES | 8-OXOGUANINE | GENE | DEGRADATION | Cell Cycle - genetics | Antigens, Nuclear - metabolism | Humans | DNA Repair Enzymes - genetics | Homologous Recombination | RNA - genetics | Cockayne Syndrome - pathology | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | RNA Interference | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Transcription, Genetic | G1 Phase - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RNA - metabolism | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | Cockayne Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Blotting, Western | Rad52 DNA Repair and Recombination Protein - genetics | DNA Helicases - metabolism | Microscopy, Confocal | Antigens, Nuclear - genetics | Resting Phase, Cell Cycle - genetics | Ku Autoantigen | DNA Repair | Cockayne Syndrome - genetics | Cell Line, Tumor | Models, Genetic | DNA Damage | HeLa Cells | Physiological aspects | Observations | Genetic recombination | RNA polymerases | Biological Sciences | PNAS Plus
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3. Full Text How RNA transcripts coordinate DNA recombination and repair
by McDevitt, Shane and Rusanov, Timur and Kent, Tatiana and Chandramouly, Gurushankar and Pomerantz, Richard T
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1091 - 10
Genetic studies in yeast indicate that RNA transcripts facilitate homology-directed DNA repair in a manner that is dependent on RAD52. The molecular basis for... 
HUMAN RAD52 PROTEIN | STRAND BREAK REPAIR | HOMOLOGOUS RECOMBINATION | MULTIDISCIPLINARY SCIENCES | COMPLEXES | Rad52 DNA Repair and Recombination Protein - metabolism | Recombinational DNA Repair - genetics | Recombinational DNA Repair - physiology | DNA Repair - physiology | Saccharomyces cerevisiae Proteins - metabolism | DNA Repair - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA Breaks, Double-Stranded | Rad52 DNA Repair and Recombination Protein - genetics | RNA - genetics | Hybrids | Recombination | Yeast | Nucleotide sequence | DNA damage | Licenses | Reverse transcription | Homology | Ribonucleic acid--RNA | DNA repair | Repair | Recombinant RNA | Deoxyribonucleic acid--DNA | Rad52 protein | Recombinant
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4. Full Text Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
by Bennardo, Nicole and Cheng, Anita and Huang, Nick and Stark, Jeremy M
PLoS Genetics, ISSN 1553-7390, 06/2008, Volume 4, Issue 6, pp. e1000110 - e1000110
Characterizing the functional overlap and mutagenic potential of different pathways of chromosomal double-strand break (DSB) repair is important to understand... 
CELLS | ATP HYDROLYSIS | DIRECTED DNA-REPAIR | CTIP | GENETICS & HEREDITY | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | END RESECTION | PROTEINS | SACCHAROMYCES-CEREVISIAE | Endonucleases - genetics | Antigens, Nuclear - metabolism | Chromosomes, Mammalian - genetics | Humans | Green Fluorescent Proteins - genetics | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Deoxyribonucleases, Type II Site-Specific - genetics | DNA-Binding Proteins - metabolism | Rad52 DNA Repair and Recombination Protein - metabolism | Nuclear Proteins - genetics | Chromosome Breakage | Genes, Reporter | Rad51 Recombinase - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Rad52 DNA Repair and Recombination Protein - genetics | Carrier Proteins - genetics | Deoxyribonucleases, Type II Site-Specific - metabolism | Animals | Antigens, Nuclear - genetics | Carrier Proteins - metabolism | Ku Autoantigen | DNA Repair | Saccharomyces cerevisiae Proteins | Mice | Index Medicus | Annealing | DNA damage | Cloning | DNA repair | Experiments | Cancer therapies | Proteins | Mutagenesis | Plasmids | Deoxyribonucleic acid | DNA | Genetics | Mutation | Cancer
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5. Full Text RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress
by Bhowmick, Rahul and Minocherhomji, Sheroy and Hickson, Ian D
Molecular Cell, ISSN 1097-2765, 12/2016, Volume 64, Issue 6, pp. 1117 - 1126
Homologous recombination (HR) is necessary to counteract DNA replication stress. Common fragile site (CFS) loci are particularly sensitive to replication... 
replication stress | homologous recombination | mitosis | break-induced replication | conservative DNA synthesis | HOLLIDAY JUNCTION RESOLUTION | COMMON FRAGILE SITES | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHETICALLY LETHAL | R-LOOPS | HOMOLOGOUS RECOMBINATION | SACCHAROMYCES-CEREVISIAE | CANCER | BREAK-INDUCED REPLICATION | DOUBLE-STRAND-BREAK | CELL BIOLOGY | Endonucleases - genetics | DNA Polymerase III - genetics | Mitosis | Humans | Stress, Physiological | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Rad52 DNA Repair and Recombination Protein - metabolism | Endodeoxyribonucleases - metabolism | Osteoblasts - cytology | Rad51 Recombinase - metabolism | Recombinational DNA Repair | Rad51 Recombinase - genetics | Chromosome Fragile Sites | DNA Replication | DNA - metabolism | DNA-Binding Proteins - genetics | Rad52 DNA Repair and Recombination Protein - genetics | DNA - genetics | Endodeoxyribonucleases - genetics | BRCA2 Protein - metabolism | Cell Line, Tumor | DNA Damage | HeLa Cells | DNA Polymerase III - metabolism | Osteoblasts - metabolism | BRCA2 Protein - genetics | Nucleases | DNA synthesis | DNA replication | DNA | Cells
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6. Full Text Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
by Yasuhara, Takaaki and Kato, Reona and Hagiwara, Yoshihiko and Shiotani, Bunsyo and Yamauchi, Motohiro and Nakada, Shinichiro and Shibata, Atsushi and Miyagawa, Kiyoshi
Cell, ISSN 0092-8674, 10/2018, Volume 175, Issue 2, pp. 558 - 570.e11
Given that genomic DNA exerts its function by being transcribed, it is critical for the maintenance of homeostasis that DNA damage, such as double-strand... 
Rad52 | transcription-associated homologous recombination repair | non-homologous end-joining | R-loop | DNA-RNA hybrid | genomic instability | DNA double-strand break | XPG | PATHWAY CHOICE | STRAND BREAK REPAIR | REPLICATION FORKS | LANDSCAPE | DNA-DAMAGE RESPONSE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATM | GENOME STABILITY | BRCA1 | NUCLEOTIDE EXCISION-REPAIR | CELL BIOLOGY | Cell Line | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Humans | Homologous Recombination | Nuclear Proteins - metabolism | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Rad52 DNA Repair and Recombination Protein - genetics | RNA - genetics | DNA - genetics | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Rad52 DNA Repair and Recombination Protein - metabolism | DNA End-Joining Repair | DNA Repair | Recombinational DNA Repair - physiology | Nuclear Proteins - physiology | DNA Damage | Nuclear Proteins - genetics | Endonucleases - physiology | Biotechnology | Medical colleges | RNA | DNA damage | Genes | Genetic transcription | DNA repair | Cells
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7. Full Text ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
by Teng, Yaqun and Yadav, Tribhuwan and Duan, Meihan and Tan, Jun and Xiang, Yufei and Gao, Boya and Xu, Jianquan and Liang, Zhuobin and Liu, Yang and Nakajima, Satoshi and Shi, Yi and Levine, Arthur S and Zou, Lee and Lan, Li
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4115 - 12
Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous... 
OXIDATIVE STRESS | STRAND BREAK REPAIR | REPLICATION | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | SYNTHETICALLY LETHAL | GENOME STABILITY | IONIZING-RADIATION | BRCA2 | RAD52 INACTIVATION | ACTIVE GENES | Reactive Oxygen Species - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Humans | DNA Repair Enzymes - genetics | Homologous Recombination | Rad52 DNA Repair and Recombination Protein - metabolism | BRCA1 Protein - metabolism | Base Sequence | DNA Repair Enzymes - metabolism | HEK293 Cells | Transcription, Genetic | DNA Helicases - genetics | Rad51 Recombinase - metabolism | Amino Acid Sequence | Rad51 Recombinase - genetics | Poly-ADP-Ribose Binding Proteins - genetics | DNA - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA - genetics | Sequence Homology, Amino Acid | BRCA1 Protein - genetics | DNA Helicases - metabolism | BRCA2 Protein - metabolism | DNA Repair | Cell Line, Tumor | DNA Damage | BRCA2 Protein - genetics | BRCA2 protein | Cockayne syndrome | Hybrids | BRCA1 protein | Transcription | Homologous recombination | Homology | Breast cancer | Genomes | Protein B | Ribonucleic acid--RNA | DNA repair | Damage localization | Proteins | Localization | Deoxyribonucleic acid--DNA | Rad52 protein
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8. Full Text Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
by Ferrari, Matteo and Dibitetto, Diego and De Gregorio, Giuseppe and Eapen, Vinay V and Rawal, Chetan C and Lazzaro, Federico and Tsabar, Michael and Marini, Federica and Haber, James E and Pellicioli, Achille
PLoS Genetics, ISSN 1553-7390, 2015, Volume 11, Issue 1, p. e1004928
The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 59-to-39 resection of Double-Strand DNA Breaks (DSBs). Extended 39 single stranded DNA... 
PATHWAY CHOICE | SGS1 HELICASE | BRCT DOMAIN | EXO1 | PHOSPHORYLATION | GENETICS & HEREDITY | CELL-CYCLE | DNA HELICASE | CHECKPOINT | HOMOLOGOUS RECOMBINATION | PROMOTES RESECTION | Endonucleases - genetics | DNA End-Joining Repair - genetics | RecQ Helicases - metabolism | Cell Cycle Proteins - metabolism | RecQ Helicases - genetics | Endonucleases - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA Breaks, Double-Stranded | Rad52 DNA Repair and Recombination Protein - genetics | DNA, Single-Stranded - genetics | Endodeoxyribonucleases - genetics | Rad52 DNA Repair and Recombination Protein - metabolism | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cell Cycle Proteins - genetics | Homologous Recombination - genetics | Exodeoxyribonucleases - genetics | Mutation | Saccharomyces cerevisiae | Proteins | Yeast | Deoxyribonucleic acid | DNA | Cell cycle | Genomes | DNA repair | Experiments
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9. Full Text RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination
by Lok, B.H and Carley, A.C and Tchang, B and Powell, S.N
Oncogene, ISSN 0950-9232, 07/2013, Volume 32, Issue 30, pp. 3552 - 3558
Synthetic lethality is an approach to study selective cell killing based on genotype. Previous work in our laboratory has shown that loss of RAD52 is... 
RAD52 | RAD51 | BRCA1 | Synthetic lethality | BRCA2 | PALB2 | POLY(ADP-RIBOSE) POLYMERASE | CELLS | COMPLEX | STRAND BREAK REPAIR | PHOSPHORYLATION | REPLICATION PROTEIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | synthetic lethality | TUMORS | DAMAGE | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | CANCER SUSCEPTIBILITY GENE | DNA-REPAIR | Cell Survival - drug effects | DNA Repair - drug effects | Rad51 Recombinase - genetics | Humans | RNA, Small Interfering - pharmacology | Gene Silencing | Genes, Lethal - physiology | Cell Survival - genetics | DNA Repair - genetics | Rad52 DNA Repair and Recombination Protein - genetics | Rad52 DNA Repair and Recombination Protein - physiology | Gene Knockdown Techniques | Homologous Recombination - physiology | Genes, BRCA1 - physiology | Genes, BRCA2 - physiology | Genes, Lethal - genetics | Tumor Suppressor Proteins - genetics | Rad51 Recombinase - physiology | Cell Line, Tumor | Homologous Recombination - genetics | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Physiological aspects | Research | Genetic recombination | BRCA mutations | Rad51 proteins | Epigenetics | Oncology | Genetic engineering | Gene therapy | Cancer therapies
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10. Full Text Mechanics and Single-Molecule Interrogation of DNA Recombination
by Bell, Jason C and Kowalczykowski, Stephen C
Annual Review of Biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 193 - 226
The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity process that mends DNA lesions formed during cellular metabolism;... 
microscopy | helicase | visual biochemistry | BRCA2 | DNA repair | RecA RAD51 | Helicase | Microscopy | RecA/RAD51 | Visual biochemistry | BREAST-CANCER SUSCEPTIBILITY | REPLICATION PROTEIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | DOUBLE-STRANDED DNA | SACCHAROMYCES-CEREVISIAE | COLI RECA PROTEIN | RAD51 FILAMENT FORMATION | REAL-TIME OBSERVATION | RECBCD ENZYME | HOMOLOGOUS RECOMBINATION | Exodeoxyribonuclease V - genetics | Genomic Instability | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | RecQ Helicases - genetics | Single Molecule Imaging | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Rad52 DNA Repair and Recombination Protein - metabolism | Recombination, Genetic | Endodeoxyribonucleases - metabolism | Escherichia coli - metabolism | Exodeoxyribonucleases - genetics | Recombinational DNA Repair | Gene Expression Regulation | Exodeoxyribonuclease V - metabolism | DNA - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Rad52 DNA Repair and Recombination Protein - genetics | DNA - genetics | Endodeoxyribonucleases - genetics | Escherichia coli - genetics | Chromosome Aberrations | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Damage | Nucleotide sequencing | Genetic recombination | Observations | Methods | DNA sequencing
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